Glycosuria

The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).

Networked: 781 relevant articles (35 outcomes, 47 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperglycemia
2.	Polyuria
3.	Body Weight (Weight, Body)
4.	Renal Tubular Acidosis (Distal Renal Tubular Acidosis)
5.	Diabetes Mellitus

Experts

1.	Ferrannini, Ele: 3 articles (09/2015 - 05/2013)
2.	Nadri, Gulnaz: 3 articles (05/2014 - 01/2011)
3.	Singh, Varinder: 3 articles (05/2014 - 01/2011)
4.	Chandra, Jagdish: 3 articles (05/2014 - 01/2011)
5.	Patra, Soumya: 3 articles (05/2014 - 01/2011)
6.	Pemde, Harish K: 3 articles (05/2014 - 01/2011)
7.	Chowdhary, Harish: 3 articles (05/2014 - 01/2011)
8.	Lawlor, Debbie A: 3 articles (01/2012 - 04/2004)
9.	Fiorucci, Stefano: 3 articles (03/2010 - 04/2004)
10.	Brancaleone, Vincenzo: 3 articles (03/2010 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Glycosuria:

1.	Glucose (Dextrose)FDA LinkGeneric 01/01/1984 - "In the first instance, a significant improvement both in the plasma glucose levels, as well as in the daily glucose profile and glycosuria was observed. " 09/01/1982 - "On the alternative program, control improved markedly in 23 of the 25 patients, as evidenced by lower fasting serum glucose concentrations and decreased glycosuria. " 01/01/1980 - "A further HbAI decrease was observed until day 60 following Biostator treatment, during which period glycaemic control improved, as assessed by fasting and post-lunch plasma glucose values and daily glycosuria determined every 10 days. " 06/01/2010 - "Urine testing for glucose is commonly performed during pregnancy but little is known about the regulation and clinical value of glycosuria because studies are hampered by its low prevalence and intermittent nature. " 01/01/2007 - "In this study, we have compared ClC-5 KO mice with age and gender matched wild-type (WT) control mice to investigate if the underlying cause of manifested glycosuria is an impairment of glucose homeostasis and/or an alteration in expression levels of proximal tubule (PT) glucose transporters. "
2.	Insulin (Novolin)FDA Link 02/01/1982 - "These findings indicate that insulin treatment (sufficient to reduce daily glycosuria) applied during the overtly diabetic period markedly improved the recovery of the insulin stores in the pancreas. " 05/01/1992 - "The goal of this study was to evaluate how dietary phosphate depletion affected the relative effects of insulin deficiency and glycosuria on the tubular reabsorption of phosphate. " 06/01/1989 - "The present study involved treating BB diabetic rats with a low (hyperglycemic) and high (normoglycemic) insulin dose for 12 weeks after the detection of glycosuria. " 01/01/2008 - "Plasma insulin concentrations and glycosuria were determined. " 07/01/2005 - "Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers."
3.	Blood Glucose (Blood Sugar)IBA 04/15/2004 - "Our study suggests that glycosuria is not only dependent on the blood glucose level, but highly influenced by diastolic blood pressure. " 01/01/2001 - "The side effects of higher blood sugar levels and glycosuria were found in the 2 trials where these were sought. " 01/01/2000 - "The side effects of higher blood sugar levels and glycosuria were found in the 2 trials where these were sought. " 05/01/1991 - "Laboratory studies showed raised ESR, 4+ glycosuria, and a blood sugar of 351mg/dl. " 07/01/1980 - "The results of this study suggest that (1) although there is a positive correlation between GlHb and FPG, the two tests cannot be used interchangeably in the evaluation of diabetic control; and (2) in the majority of the patients the absence of glycosuria tends to create the false assurance of satisfactory blood glucose control."
4.	Triglycerides (Triacylglycerol)IBA 01/01/1983 - "The levels of glycosylated hemoglobin (Hb AI), intermittent glycemia and glycosuria over 24 hr, Mw index, fasting serum cholesterol and triglycerides, and 24-hr proteinuria were determined in 20 healthy subjects and 88 diabetics representing different clinical types of diabetes mellitus. " 06/01/2000 - "Insulin 1) reduces glycosuria and its caloric expenditure; 2) stimulates the stockage of fatty acids into triglycerides in adipose tissue, thus favoring an increase in adipose mass; 3) yields a positive nitrogen balance through an inhibition of muscle proteolysis, thus favoring an increase in lean mass. " 01/01/1999 - "sulphonylurea or biguanide derivatives); personal data (age, height, weight, etc.); blood glucose level prior to and 2 hours postprandial; glycosuria; basic additional tests; basic lipid tests (total cholesterol, triglycerides); overall score of acarbose use (side effects, withdrawal, physicians and patients opinion on the drug). " 01/01/2007 - "Caffeine significantly reduced body weight and glycosuria (weeks 2-9), improved glucose tolerance (week 9), had no effect on elevated plasma triglycerides, plasma cholesterol (week 9) and blood pressure (week 9), and significantly increased plasma cholesterol level (weeks 5 and 9). " 10/01/1989 - "The other investigated parameters (blood sugar on fasting and after a meal, glycosuria, glycosylated proteins, C-peptide on fasting and after a meal, triacylglycerol and cholesterol) were not influenced by a single nor by long-term intake of Sinecal. "
5.	CholesterolIBA 11/17/1962 - "Diet, serum cholesterol, protein, blood haemoglobin, and glycosuria in a West Indian community (St. Kitts, W.I.). " 01/01/2009 - "However, this resistance did not seem to have protected the kidneys as expected because organic anion accumulation associated with glycosuria and proteinuria, in addition to the elevated urinary cholesterol levels, all imply the presence of an impaired glomerular permeability and reabsorption in the proximal tubule cells. " 09/01/1987 - "Fiber supplement studies with guar, wheat bran, and apple fiber produced mixed results; some studies reported lowered fasting glucose and cholesterol values and less glycosuria. " 06/01/2005 - "This difference was 2000 yen per month after adjusting for age, body mass index, smoking, systolic blood pressure, glycosuria, serum total cholesterol and alanine aminotransferase. " 09/30/2005 - "The administration of STZ caused significant increases in levels of glycosuria, proteinuria, albuminuria, glycemia, total cholesterol and AI, as well as in lipid peroxidation products in the brain, plasma and kidney, whereas it decreased the GSH content and SOD, GSH-Px and catalase activities. "
6.	Uric Acid (Urate)IBA 10/01/2014 - "SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria." 10/01/1980 - "Proximal tubular dysfunction, resembling adult Fanconi's syndrome, was suggested by an increased urinary loss of phosphate and urate and glycosuria. " 04/01/2015 - "Estimated glomerular filtration rate (eGFR) and markers of tubular damage to assess tubular dysfunction (fractional excretion of phosphate and uric acid, glycosuria, and proteinuria) were measured at baseline and at weeks 12 and 24. " 01/15/2015 - "Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus." 10/01/2014 - "In contrast, diabetic patients with glycosuria had a null prevalence of hyperuricemia and excreted more uric acid and Na than diabetic subjects without glycosuria. "
7.	C-PeptideIBA 04/01/1983 - "On the contrary, the ratio Ln 24-hr glycosuria: 24-hr urinary C-peptide varied from 0.00 to 0.18 in the control group and in normally working pancreatic grafts; when the pancreatic grafts failed, however, as confirmed by arteriographic evidence, histologic findings, or dynamic endocrine tests, this ratio rose far higher than 0.18, reaching values as high as 12.2. " 11/01/1997 - "No significant differences were found in the two age-groups with respect to glycaemia, glycosuria, ketonuria, and fasting C-peptide levels. " 01/01/1987 - "The largest partial remission (C-peptide 0.3 nM, insulin requirement less than 0.5 U X kg-1 X day-1 and no glycosuria) was observed in group 1 after 180 days (5 of 16 patients) and in group 2 after 60 days (5 of 15 patients).(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1984 - "Fasting C-peptide negatively correlated also to mean daily plasma glucose, 24-h glycosuria, and fasting free fatty acid concentration. " 02/01/1980 - "Although the concentrations of post-stimulatory C-peptide correlated inversely with both the 24-hour glycosuria (P less than 0.01) and the fasting blood glucose concentrations (P less than 0.02), only a subgroup with C-peptide concentrations exceeding 0.30 pmol/ml showed a definitely better degree of metabolic control than those without beta-cell function. "
8.	Hemoglobins (Hemoglobin)IBA 09/27/1993 - "The area under the relative operating characteristic curve was significantly greater for glycated hemoglobin than for either measure of glycosuria. " 03/01/2012 - "Case 1: a 4-yr-old girl referred for glycosuria presented hemoglobin A1c (HbA1c) of 6.6%. " 09/27/1993 - "Glycated hemoglobin, quantitative glycosuria, and dipstick glycosuria were compared in 237 nonfasting subjects. " 09/29/2015 - "We observed combinations of pregnancy complications that predict high risk of death and 2 new risk markers, glycosuria and hemoglobin decline. " 06/01/1984 - "Urinary NAG increases more rapidly than hemoglobin A1 after onset of hyperglycemia and glycosuria.(ABSTRACT TRUNCATED AT 250 WORDS)"
9.	Vanadates (Orthovanadate)IBA 01/01/1995 - "After the first month of treatment U-83836E improved significantly the protective effect of vanadate alone on polydipsia and polyuria, but more efficiently on hyperglycemia and glycosuria. " 09/01/1994 - "At subsequent steps, U-83836E significantly improved the protective effect of vanadate alone on polydipsia and polyuria, but especially on hyperglycemia and glycosuria. "
10.	Caffeine (No Doz)FDA LinkGeneric 01/01/2007 - "Caffeine significantly reduced body weight and glycosuria (weeks 2-9), improved glucose tolerance (week 9), had no effect on elevated plasma triglycerides, plasma cholesterol (week 9) and blood pressure (week 9), and significantly increased plasma cholesterol level (weeks 5 and 9). " 04/01/2002 - "Caffeine significantly reduced body weight, glycosuria, fasting glucose and insulin levels and improved glucose tolerance, had no effect on elevated plasma triglycerides levels and significantly increased plasma cholesterol level (P < 0.001). "

Therapies and Procedures

1.	Intravenous Injections 11/01/1986 - "Compounds were tested by intravenous injection into rats and diabetogenic activity assessed by production of persistent hyperglycaemia and glycosuria. " 06/01/1918 - "However, in an earlier study carried out several years ago we arrived at the conception that the more slowly adrenalin was absorbed from the tissues into the circulation, the greater was its glycosuric effect; hence an intramuscular injection, which in its effect is nearly equal to that of an intravenous injection, induced a glycosuria definitely smaller than that set up by a similar dose administered subcutaneously. " 10/15/1986 - "Here we report that intravenous injections of 4.92 mmol of Na2SO4/kg body wt. to rats induced marked hepatic glycogenolysis in vivo, accompanied by polyuria, glycosuria and a mild hyperglycaemia. " 06/01/1918 - "Concerning Herter's claim that intraperitoneal injection gives a higher degree of glycosuria than subcutaneous or intravenous injection, we offer no comment since we have made no observations on the glycosuric effect of subcutaneous injection of adrenalin, while we have made only three experiments by intraperitoneal injection. " 05/01/1986 - "Rats received an intravenous injection of 60 mg/kg streptozotocin and were tested for glycosuria 3 days later. "
2.	Pancreatectomy 10/01/2008 - "Predictive value of postoperative glycosuria after partial elective pancreatectomy in focal congenital hyperinsulinism." 03/20/1982 - "Dragstedt reported that the amount of insulin required to control glycosuria after partial pancreatectomy is much greater than that needed after total pancreatectomy. " 01/01/2014 - "Original studies conducted in experimental animals with the nonspecific SGLT inhibitor phlorizin showed that hyperglycemia after pancreatectomy decreased as a result of forced glycosuria. " 01/01/1988 - "Glycosuria and kidney weight were significantly reduced by subtotal pancreatectomy, although creatinine clearance and blood glucose levels were not different from diabetic controls. " 06/01/1977 - "In group III, a cephalic pancreatectomy was performed after the injection of neoprene into the pancreatic ducts, 8 animals were alive and well after 3 to 15 months, and showed a normal level of blood sugar, insulin, glucagon and amylase without glycosuria."
3.	Intramuscular Injections 06/01/1918 - "However, in an earlier study carried out several years ago we arrived at the conception that the more slowly adrenalin was absorbed from the tissues into the circulation, the greater was its glycosuric effect; hence an intramuscular injection, which in its effect is nearly equal to that of an intravenous injection, induced a glycosuria definitely smaller than that set up by a similar dose administered subcutaneously. " 08/01/1913 - "Subcutaneous injections of adrenalin are, in contrast with its behavior in the production of the other effects of that drug, more favorable to the production of glycosuria in rabbits than intramuscular injections; the failures are fewer and the quantities of dextrose in the urine are generally larger. "
4.	Anesthesia 08/01/1912 - "5. The glycosuria does not make its appearance until the condition of anesthesia has been produced. " 08/01/1912 - "2. Associated with this anesthesia a glycosuria occurs in healthy adult dogs fed on a meat diet. " 08/01/1912 - "STUDIES IN GLYCOSURIA : SECOND PAPER: GLYCOSURIA FOLLOWING ANESTHESIA PRODUCED BY THE INTRAVENOUS INJECTION OF ETHER."
5.	Injections 03/01/1989 - "Despite diabetic signs such as glycosuria and ketouria, no ultrastructural alterations were found in islet cells up to 90 days after the beginning of the Fe3+-NTA injections. " 09/01/1982 - "Eighteen young female NOD mice without glycosuria were randomly divided into two groups; nine received subcutaneous nicotinamide (0.5 mg/g body wt) injections every day and the other nine were maintained as a control group and not injected. " 01/01/1899 - "(3) Injections of diphtheria antitoxin are occasionally followed for a few days by a slight glycosuria." 01/01/1987 - "The diabetic rats were kept alive by injections of small doses of insulin and exhibited severe hyperglycaemia, glycosuria and weight loss. " 01/01/2011 - "Diabetes was confirmed by glycosuria (>2%) and elevated plasma glucose (>300 mg/100 ml) after three days of alloxan injections. "