Glycosphingolipids

Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)

Also Known As:

Networked: 554 relevant articles (8 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shayman, James A: 7 articles (08/2015 - 02/2003)
2.	Schiffmann, Raphael: 6 articles (06/2015 - 12/2003)
3.	Furukawa, Koichi: 5 articles (04/2015 - 08/2003)
4.	Oliveira, João Paulo: 5 articles (09/2014 - 07/2010)
5.	Butters, Terry D: 5 articles (03/2014 - 11/2002)
6.	Warnock, David G: 5 articles (01/2013 - 09/2006)
7.	Müthing, Johannes: 5 articles (06/2012 - 03/2008)
8.	Aerts, Johannes M F G: 5 articles (01/2012 - 09/2008)
9.	Aerts, Johannes M: 5 articles (01/2011 - 09/2004)
10.	Cheng, Seng H: 4 articles (06/2015 - 05/2007)

Related Diseases

1.	Colitis 09/01/2008 - "The immune modulatory effect of beta-glycosphingolipids was associated with increased survival and significant alleviation of colitis as determined by improvement in both the macroscopic and microscopic scores. " 09/01/2008 - "In conclusion, administration of beta-glycosphingolipids increased NKT regulatory lymphocyte redistribution and intrahepatic CD8(+) T lymphocyte trapping, resulting in alleviation of immune-mediated colitis. " 01/16/2014 - "fragilis glycosphingolipids-exemplified by an isolated peak (MW = 717.6) called GSL-Bf717-reduces colonic iNKT cell numbers and confers protection against oxazolone-induced colitis in adulthood. "
2.	Neoplasms (Cancer) 03/01/2001 - "To study the relationship between MDR and expression of N-glycosphingolipids (H-GSLs) in tumor cells. " 01/01/1993 - "Tumor cell lines are commonly used in tumor biology studies, but the expression of tumor-associated glycosphingolipids in tumor cell lines does not always reflect their expression in the tumor tissue from which the cell line originates. " 01/30/2015 - "Abnormal glycosphingolipids (GSLs) are expressed in many human tumors. " 12/01/2010 - "We have precisely analyzed the structures of glycosphingolipids of human cancer cells and normal epithelial cells using several methods, including enzymatic release of carbohydrate moieties, fluorescent labeling, and identification using 2D mapping, enzymatic digestion, and mass spectrometry. " 01/01/2010 - "Glycosphingolipids as mediators of phenotypic changes associated with development and cancer progression."
3.	Insulin Resistance 01/01/2011 - "However, the recent finding in animal models that pharmacological reduction of glycosphingolipid biosynthesis ameliorates insulin resistance and prevents some manifestations of metabolic syndrome, supports the view that somehow glycosphingolipids act as critical regulators, Importantly, since reductions in glycosphingolipid biosynthesis have been found to be well tolerated, such approaches may have a therapeutic potential." 12/01/2006 - "Consistent with these inhibitor studies, pharmacological accumulation of glycosphingolipids increased activation of the endoplasmic reticulum stress response, a putative modulator of insulin resistance and neuronal apoptosis. " 09/01/2015 - "Glycosphingolipids are involved in the pathogenesis of type 2 diabetes induced by insulin resistance, but the details of the glycosphingolipid molecular species composition of adipocytes have yet to be elucidated. " 01/01/2011 - "In recent times a crucial role for glycosphingolipids in insulin resistance has been proposed. " 01/01/2011 - "Glycosphingolipids and insulin resistance."
4.	Gaucher Disease (Gaucher's Disease) 09/01/2011 - "Gaucher's disease is the most prevalent disease of accumulation of glycosphingolipids. " 08/01/2007 - "Gaucher disease type 1 (GD1) is an autosomal recessive lysosomal storage disorder, characterised by accumulation of glycosphingolipids in visceral organs. " 07/15/2008 - "Niemann-Pick disease types A and C, and Gaucher disease are glycolipid storage disorders characterized by the systemic deposition of glycosphingolipids, i.e., sphingomyelin in Niemann-Pick disease types A and C tissues and glucosylceramide in Gaucher disease ones, respectively. " 06/01/1999 - "Gaucher's disease (GD) is characterized by hepatosplenomegaly, bone marrow infiltration, osteonecrosis, which may all be associated with the presence of pathological macrophages that contain undegraded glycosphingolipids. " 01/01/1997 - "Gaucher's disease is characterized by hepatosplenomegaly, bone-marrow infiltration, osteonecrosis and bone thinning, associated with the presence of pathological macrophages that contain undegraded glycosphingolipids. "
5.	Paracoccidioidomycosis (South American Blastomycosis) 10/01/2014 - "We tested the hypothesis that glycosphingolipids from Paracoccidioides brasiliensis have immunomodulatory properties on monocytes and dendritic cells of two groups of healthy individuals, one cured of paracoccidioidomycosis in the past (CUR-I) and the other nonexposed to P. " 02/01/2007 - "Expression of antibodies directed to Paracoccidioides brasiliensis glycosphingolipids during the course of paracoccidioidomycosis treatment."

Related Drugs and Biologics

1.	ceramide glucosyltransferase
2.	Antibodies
3.	Fatty Acids (Saturated Fatty Acids)
4.	Phosphotransferases (Kinase)
5.	Oxazolone
6.	tyrosine receptor (receptor, tyrosine)
7.	Gangliosides
8.	Lipids
9.	sphingosine 1-phosphate (sphingosine-1-phosphate)
10.	alpha-Galactosidase (Beano)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Enzyme Replacement Therapy
4.	Diskectomy (Discectomy)
5.	Lenses