Glycosaminoglycans

Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.

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Networked: 2808 relevant articles (37 outcomes, 240 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Giugliani, Roberto: 30 articles (02/2015 - 04/2005)
2.	Ponder, Katherine P: 18 articles (12/2014 - 02/2007)
3.	Haskins, Mark E: 15 articles (11/2015 - 02/2004)
4.	Jakóbkiewicz-Banecka, Joanna: 14 articles (01/2015 - 01/2005)
5.	Linhardt, Robert J: 11 articles (06/2015 - 02/2006)
6.	Volpi, Nicola: 11 articles (06/2014 - 03/2003)
7.	Baldo, Guilherme: 10 articles (02/2015 - 12/2011)
8.	van Kuppevelt, Toin H: 10 articles (12/2014 - 06/2003)
9.	Sugahara, Kazuyuki: 10 articles (10/2014 - 08/2007)
10.	Maccari, Francesca: 10 articles (06/2014 - 03/2003)

Related Diseases

1.	Mucopolysaccharidoses 01/01/1982 - "High-resolution electrophoresis of urinary glycosaminoglycans: an improved screening test for the mucopolysaccharidoses." 01/01/2010 - "Only some of these products were found to be effective in inhibition of the synthesis of glycosaminoglycans (compounds whose degradation is severely impaired in mucopolysaccharidoses, including Sanfilippo disease) in cultured fibroblasts. " 02/01/1990 - "Two methods for analysis of urinary glycosaminoglycans (GAGs) have been modified and improved for efficient screening of mucopolysaccharidoses. " 01/01/2010 - "Neonatal screening for mucopolysaccharidoses by determination of glycosaminoglycans in the eluate of urine-impregnated paper: preliminary results of an improved DMB-based procedure." 01/01/1997 - "Mucopolysaccharidoses type II: enzymatic activity and quantitative and qualitative studies of urinary glycosaminoglycans in five patients."
2.	Wounds and Injuries (Trauma) 12/01/2011 - "This study aims to evaluate the effects of simulated birth trauma and vaginal and Cesarean delivery on glycosaminoglycans (GAGs) in the vagina of female rats. " 06/01/2010 - "This study assesses the effects of simulated birth trauma, vaginal and cesarean delivery on glycosaminoglycans in the connective tissue of female rat urethra. " 09/01/2000 - "The aim of the current study was to examine the effect of early treatments with polysulphated glycosaminoglycans on cartilage using an in vivo post-trauma animal model. " 02/01/1961 - "[Biochemical studies on healing mechanisms of corneal wounds, especially on changes of corneal mucopolysaccharides. " 12/01/2014 - "In addition, the antimicrobial activity of HG1 isomers was examined in the presence of glycosaminoglycans or lipid components occurring in the extracellular matrix, human serum and wound fluid. "
3.	Neoplasms (Cancer) 09/01/1973 - "The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. " 11/15/2007 - "Thus, these findings introduce a new approach to improve the delivery and efficacy of oncolytic viral vectors: modulation of tumor glycosaminoglycans to enhance convection." 03/01/2011 - "Numerous studies have focused on this issue, and have demonstrated that glycosaminoglycans play a crucial role in cancer growth and invasion. " 12/01/1978 - "Qualitative studies indicate that progressive alterations occur in the epidermal-dermal basement membrane and dermal conncecive tissue and mucopolysaccharides associated with the progressive development of epidermal cancers. " 02/01/1973 - "A study of the effect of acid mucopolysaccharides on the growth of experimental tumors in mice."
4.	Infection 04/01/2004 - "Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans." 06/01/2006 - "Competition studies and time course experiments suggest that interactions of HCV with cell surface-resident glycosaminoglycans aid in efficient infection of Huh7 cells and that CD81 acts during a postattachment step. " 02/01/2004 - "The aims of this study were to verify the role of sulphated glycosaminoglycans in chlamydial infection and to investigate whether they are present on chlamydia or chlamydial host cells. " 07/20/2001 - "In the present study, we found that highly sulfated glycosaminoglycans (GAGs) are involved in infection of both neurovirulent (RP-9) and attenuated (RP-2ms) JEV strains. " 01/01/1997 - "Thus, this study provides direct evidence that a principal role for cell surface glycosaminoglycans in HSV infection is to provide an efficient matrix for virus adsorption. "
5.	Inflammation 12/01/2000 - "The breakdown of glycosaminoglycans is an important consequence of inflammation at mucosal surfaces, and inhibition of metalloprotease activity may be effective in treating chronic inflammation. " 08/01/2014 - "A total of 13 laboratory studies showed how bladder glycosaminoglycans instillations act: attenuation of the inflammation process, reduction of bladder contraction amplitude and frequency, reduction of epithelium damage, and lower bacterial growth in urine and tissue samples. " 03/01/2015 - "The biochemical structure comprises four different types of the core protein with attached glycosaminoglycans (GAGs) that can be sulfated to various extents and has the capacity to regulate differentiation of different cell types, migration, cell adhesion, proliferation, tissue stabilization and inflammation. " 03/01/2013 - "The significance of these results for the mechanisms of inflammation, particularly for fragmentation of extracellular matrix glycosaminoglycans, is discussed." 07/01/2012 - "The results reveal the structural basis for the high affinity of ECP for glycosaminoglycans and can assist in structure-based drug design of inhibitors of the protein cytotoxicity to host tissues during inflammation."

Related Drugs and Biologics

1.	Heparin (Liquaemin)
2.	Collagen
3.	Proteoglycans (Proteoglycan)
4.	Glycoproteins (Glycoprotein)
5.	Glycogen
6.	Hyaluronic Acid (Hyaluronan)
7.	Heparitin Sulfate (Heparan Sulfate)
8.	Enzymes
9.	glucuronyl glucosamine glycan sulfate (Vessel)
10.	Dermatan Sulfate

Related Therapies and Procedures

1.	Laser Therapy (Surgery, Laser)
2.	Enzyme Replacement Therapy
3.	Transplants (Transplant)
4.	Transplantation (Transplant Recipients)
5.	Ligation