Glycopeptides

Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.

Networked: 650 relevant articles (37 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kunz, Horst: 8 articles (04/2015 - 10/2002)
2.	Zhang, Hui: 7 articles (10/2015 - 06/2011)
3.	Papini, Anna Maria: 6 articles (01/2010 - 10/2005)
4.	Peroni, Elisa: 6 articles (01/2010 - 10/2005)
5.	Ghiselli, Roberto: 6 articles (04/2007 - 09/2002)
6.	Cirioni, Oscar: 6 articles (04/2007 - 09/2002)
7.	Orlando, Fiorenza: 6 articles (04/2007 - 09/2002)
8.	Giacometti, Andrea: 6 articles (04/2007 - 09/2002)
9.	Mocchegiani, Federico: 6 articles (04/2007 - 09/2002)
10.	Saba, Vittorio: 6 articles (04/2007 - 09/2002)

Related Diseases

1.	Infection 10/01/2007 - "The prophylactic use of glycopeptides in paediatric patients at high risk of MRSA infection undergoing cardiac surgery was safe and effective. " 03/01/2006 - "aureus resistance to glycopeptides did not emerge until nearly 40 years after their clinical introduction, and as a result this drug class has remained the mainstay of treatment for MRSA infections. " 12/01/2005 - "Recently, large randomized clinical trials and meta-analysis showed that the addition of an aminoglycoside and/or a glycopeptides results in a more favourable outcome only in selected severe infections. " 01/17/1983 - "Immunostimulation with glycopeptides deserves further study in prophylaxis or therapy of fungal infection." 01/01/2015 - "High usage of glycopeptides in the MSSA infections treatment indicates the necessity of antimicrobial stewardship improvement and introducing molecular screening for early identification of infections."
2.	Endocarditis 10/01/2001 - "Consequences of VanE-type resistance on efficacy of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecalis." 03/01/1997 - "The efficacy of glycopeptides against BM4281 was investigated in a rabbit model of experimental endocarditis for reduction of bacterial counts in cardiac vegetations and selection of mutants with increased resistance to glycopeptides. " 09/01/1998 - "Clinical data on the use of glycopeptides in endocarditis suffer from a lack of controlled trials. " 10/01/2011 - "bovis endocarditis, although patients taking glycopeptides need close clinical OPAT monitoring." 11/01/2003 - "Influence of VanD type resistance on activities of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecium."
3.	Meningitis 02/08/2003 - "[Staphylococcus aureus meningitis with intermediate sensitivity to glycopeptides. " 05/01/1996 - "Glycopeptides which have excellent in vitro activity against the Gram-positive causal agents of meningitis unfortunately have a poor CSF penetration. " 10/01/1995 - "Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. " 09/01/1995 - "Use of glycopeptides in meningitis and the role of cerebrospinal fluid drainage are discussed. " 11/01/2007 - "The pathogen is naturally resistant to cephalosporins and some glycopeptides as well, therefore despite of syndromologic diagnosis of meningitis and initial therapy with 3rd generation cephalosporins according to the guidelines therapeutic failures with clinical consequences may occur."
4.	Soft Tissue Infections 03/01/2014 - "In the UK, methicillin-resistant Staphylococcus aureus (MRSA)-associated skin and soft tissue infections (SSTIs) are predominantly managed in the hospital using intravenous (IV) glycopeptides. " 10/01/2015 - "The efficacy of the semisynthetic glycopeptides has been demonstrated in skin and soft-tissue infections, but remains to be seen in serious methicillin-resistant Staphylococcus aureus infections. " 01/01/2012 - "Comparative randomised clinical trial against glycopeptides supports the use of daptomycin as first-line treatment of complicated skin and soft-tissue infections." 06/01/2010 - "In the attempt to overcome increasing glycopeptide- and methicillin-resistant soft tissue infections, daptomycin is presently considered as an attractive alternative to the class of glycopeptides. " 01/01/2002 - "linezolid) or quinupristin/dalfopristin are interesting alternatives to the glycopeptides in the treatment of soft tissue infections."
5.	Neoplasms (Cancer) 02/03/2014 - "Due to their high-yield radiosyntheses, the glycopeptides [(18)F]6Glc-RGD and [(18)F]Mlt-RGD were chosen for comparative biodistribution studies and dynamic small-animal PET imaging using U87MG tumor-bearing nude mice. " 01/01/2008 - "In the present study, the glycan profiles of free and complexed forms of PSA from cancer patient serum and of seminal plasma PSA were compared by analyzing the glycopeptides obtained by lysylendopeptidase digestion of the electrophoretically separated PSA with mass spectrometry. " 07/01/2014 - "Here, we isolated formerly N-linked glycopeptides from normal prostate (n = 10) and from non-aggressive (n = 24), aggressive (n = 16), and metastatic (n = 25) PCa tumor tissues and analyzed the samples using SWATH mass spectrometry, an emerging data-independent acquisition method that generates a single file containing fragment ion spectra of all ionized species of a sample. " 01/01/2014 - "Current evidence shows that the empirical routine addition of antiGP treatment, namely glycopeptides, does not improve the outcomes of febrile neutropenic patients with cancer." 08/15/2013 - "These glycopeptides are potential cancer vaccine candidates. "

Related Drugs and Biologics

1.	linezolid (Zyvox)
2.	Vancomycin
3.	beta-Lactams
4.	Peptides
5.	Anti-Bacterial Agents (Antibiotics)
6.	Teicoplanin
7.	Penicillins (Penicillin)
8.	Daptomycin
9.	Cephalosporins (Cephalosporin Antibiotics)
10.	Fluoroquinolones

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Aftercare (After-Treatment)
3.	Oral Administration
4.	Immunotherapy
5.	Catheters