Glycolipids

Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)

Networked: 835 relevant articles (9 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wong, Chi-Huey: 7 articles (03/2015 - 12/2005)
2.	Galili, Uri: 7 articles (05/2013 - 04/2007)
3.	Iwamori, Masao: 6 articles (12/2012 - 10/2002)
4.	Kronenberg, Mitchell: 5 articles (01/2012 - 06/2005)
5.	Kinjo, Yuki: 5 articles (10/2011 - 06/2005)
6.	Yoshida, Hiromi: 5 articles (01/2007 - 07/2002)
7.	Mizushina, Yoshiyuki: 5 articles (01/2007 - 07/2002)
8.	Kiguchi, Kazushige: 4 articles (12/2012 - 10/2002)
9.	Zajonc, Dirk M: 4 articles (10/2011 - 12/2005)
10.	Geyer, Rudolf: 4 articles (04/2010 - 08/2002)

Related Diseases

1.	Infection 12/26/2003 - "We are currently working to determine the role that these glycolipids may play in the development of disease and in the clearance of infection." 08/01/2015 - "Furthermore, treatments of cells with inhibitors of N-, O-linked glycosylation, and glycosphingolipid synthesis suggest that glycolipids play an important role during TSPyV infection. " 01/15/2014 - "(2013) show that pathogenic mycobacteria use the coordinated action of two cell wall glycolipids to regulate macrophage recruitment to initial infection sites. " 01/01/2014 - "Here, we will address exclusively the proposed role for phthiocerol dimycocerosates (DIM) in the modulation of the resident macrophage response and that of phenolic glycolipids (PGL) in the regulation of the recruitment and phenotype of incoming macrophage precursors to the site of infection. " 07/15/2013 - "We find that iNKT cells consolidate in the marginal zone and require dendritic cells lining the splenic marginal zone for activation following administration of cognate glycolipids and during systemic infection but not following exogenous cytokine administration. "
2.	Tuberculosis (Tuberculoses) 01/01/2013 - "The results of this study demonstrated the presence of immunogenic glycolipids in Ms, which could be included to enhance the protective effects of subunit vaccine formulations against tuberculosis." 06/01/2015 - "tuberculosis sensu stricto, though simplified phenolic glycolipids remain in certain current biotypes. " 08/01/2013 - "Glycopeptidolipids (GPLs) attached to the outer surface of the greasy cell envelope, are a class of important glycolipids synthesized by several non-tuberculosis mycobacteria. " 06/07/2013 - "tuberculosis have been implicated in producing complex cell wall glycolipids, the biological function of PKS11 is unknown. " 02/01/2012 - "tuberculosis isolates, pks1 contributes to synthesis of the immunomodulatory phenolic glycolipids (PGLs). "
3.	Neoplasms (Cancer) 01/01/2015 - "Diagnosis value of membrane glycolipids biochemistry index in intracranial and gastrointestinal tumors." 02/15/2014 - "Furthermore, tumor-infiltrating MDSCs in mice injected repeatedly with α-GalCer were 2-fold higher than those treated with phenyl-glycolipids. " 01/01/2013 - "The current strategies in the battle against cancer in which glycolipids are key players are then described. " 01/01/2013 - "The aberrant glycosylation of glycolipids on the surface of the majority of cancer cells, associated with increasing evidence about the functional role of these molecules in a number of cellular physiological pathways, has received considerable attention as a convenient immunotherapeutic target for cancer treatment. " 01/01/2013 - "Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches."
4.	Gaucher Disease (Gaucher's Disease) 12/01/1972 - "Studies on neural and visceral glycolipids in a case of infantile form of Gaucher's disease." 11/01/2014 - "Gaucher disease (GD) is caused by an enzyme deficiency that leads to the accumulation of glycolipids in various organs. " 06/11/2014 - "Available cell lines modeling Gaucher disease do not demonstrate lysosomal storage of glycolipids; therefore, we set out to develop two macrophage models of Gaucher disease that exhibit appropriate substrate accumulation. " 06/01/2013 - "Glycolipids are endocytosed and targeted to the Golgi apparatus in normal cells but in Gaucher disease they are mistargeted to lysosomes. " 08/01/1977 - "Brain glycolipids in infantile Gaucher's disease."
5.	Inflammation 10/01/2014 - "Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation." 10/01/2012 - "glycosylation), cell adhesion and signal transduction, all of which are related to the anabolic metabolism of glycolipids, as well as to inflammation- and immune-related pathways. " 01/01/2012 - "The impact of glycolipids of non-mammalian origin on autoimmune inflammation has become widely recognized. " 05/01/1998 - "These glycolipids may be useful as therapeutic agents against selectin-dependent inflammation." 10/01/1984 - "These observations suggest that both a chemical and spatial reorganization of surface glycolipids occurs in response to inflammation and tumoricidal activation."

Related Drugs and Biologics

1.	Glycoproteins (Glycoprotein)
2.	Proteoglycans (Proteoglycan)
3.	Proteins (Proteins, Gene)
4.	Polysaccharides
5.	Glycoconjugates
6.	alpha-galactosylceramide
7.	Mycolic Acids (Mycolic Acid)
8.	Biological Markers (Surrogate Marker)
9.	Cytokines
10.	Dextran Sulfate

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Intravenous Injections
4.	Immunomodulation
5.	Heterologous Transplantation (Xenotransplantation)