Phosphorylases (Glucan Phosphorylase)

A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as glucose polymers, by phosphorolysis in animals (GLYCOGEN PHOSPHORYLASE) and in plants (STARCH PHOSPHORYLASE).

Also Known As:

Glucan Phosphorylase; alpha-Glucan Phosphorylases; Phosphorylase; 1,4-alpha-D-Glucan:orthophosphate alpha-D-glucosyltransferase

Networked: 508 relevant articles (4 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Hexosyltransferases
        Glucosyltransferases: 167
        Phosphorylases: 508
        Glycogen Phosphorylase: 422
        Phosphorylase a: 66
        Phosphorylase b: 13
        Starch Phosphorylase: 6
        Arabidopsis PHS2 protein
        Bifidobacterium longum galacto-N-biose-lacto-N-biose I phosphorylase
        Dictyostelium discoideum glycogen phosphorylase 2 protein

Experts

1.	Kyriakis, Efthimios: 3 articles (04/2019 - 01/2017)
2.	Leonidas, Demetres D: 3 articles (04/2019 - 01/2017)
3.	Stravodimos, George A: 3 articles (04/2019 - 01/2017)
4.	Quinlivan, R: 3 articles (02/2014 - 01/2004)
5.	Singh, Palwinder: 3 articles (04/2011 - 04/2008)
6.	Sugie, Hideo: 3 articles (06/2010 - 09/2003)
7.	Haller, Ronald G: 2 articles (01/2020 - 09/2005)
8.	Vissing, John: 2 articles (01/2020 - 09/2005)
9.	Skamnaki, Vassiliki T: 2 articles (04/2019 - 01/2018)
10.	Bokor, Éva: 2 articles (01/2018 - 01/2017)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 11/01/2006 - "Inhibition of hepatic glycogen phosphorylase is a potential treatment for glycaemic control in type 2 diabetes. " 10/06/2005 - "Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes." 11/01/2003 - "Inhibition of hepatic glycogen phosphorylase may benefit glycaemic control in patients with type 2 diabetes." 08/01/2005 - "Inhibition of hepatic glycogen phosphorylase is a promising treatment strategy for attenuating hyperglycemia in type 2 diabetes. " 06/29/2001 - "The high control coefficient of phosphorylase on glycogen synthesis affirms that phosphorylase is a strong candidate target for controlling hyperglycemia in type 2 diabetes in both the absorptive and postabsorptive states."
2.	Hyperglycemia 04/01/1980 - "Sequential study showed that hyperglycemia first induced the decrease of phosphorylase activity, then increased synthase activity. " 04/01/1991 - "Hyperglycemia did not alter the fractional activities of glycogen synthase or phosphorylase, nor total phosphorylase activity. " 01/15/1987 - "Finally, the effects of hyperglycemia on carboxylase and phosphorylase characteristics in the livers of intact rats were ascertained by taking liver samples and preparing crude extracts by the rapid freezing method described above. " 01/01/1978 - "(2) The time courses of epinephrine-induced hyperglycemia and activation of phosphorylase in liver were nearly identical. " 08/01/2005 - "Inhibition of hepatic glycogen phosphorylase is a promising treatment strategy for attenuating hyperglycemia in type 2 diabetes. "
3.	Necrosis 03/01/1977 - "Histoenzymatic study (phosphorylase activity and succinodehydrogenase activity) confirmed the existance of a marginal zone extending over one third of the surface of the ischemic myocardium: reperfusion permitted the salvage of this zone and thereby diminished the extent of necrosis. " 11/01/2000 - "The procedure induced an 80% decrease in muscle blood flow and complete suppression of phosphorylase activity without necrosis. " 02/01/1979 - "Phosphorylase activity, shortly after episodes of muscle necrosis, was identified in this patient and in others reported in the literature. " 01/01/1981 - "After 1 hour there were ultrastructural indications of the onset of permanent damage to the muscle and its associated vasculature and by 24 hours there was histological and ultrastructural evidence of ischaemic necrosis and glucan phosphorylase and myosin adenosine triphosphatase were reduced. " 07/01/1980 - "The extent of the necrosis 24 hours after its induction was estimated from the activity of creatine phosphokinase in the tissue of the left ventricle and, in rats continuously exposed to 6000 m, also by measuring the surface of necrosis marked histochemically with phosphorylase activity in histological slides. "
4.	Malignant Hyperthermia 01/01/1984 - "Phosphorylase activity and malignant hyperthermia." 03/01/1983 - "Phosphorylase ratio and susceptibility to malignant hyperthermia." 03/01/1983 - "The ratio of muscle phosphorylase a to total phosphorylase, expressed as a percent, was determined in vastus lateralis muscle of 26 patients to examine the efficacy of this parameter as a method for screening for susceptibility to malignant hyperthermia (MH). "
5.	Alkalosis 04/01/1975 - "The prior treatment of the rat with hydrocortisone was very effective in overcoming the alkalosis-induced inhibition of the beta-receptor-mediated metabolic actions of epinephrine and isoproterenol, such as the activation of liver phosphorylase, accumulation of muscle hexose phosphates, and stimulation of pancreatic secretion of insulin. "

Related Drugs and Biologics

1.	Liver Glycogen
2.	Insulin (Novolin)
3.	Phosphates (Orthophosphate)
4.	Hexoses
5.	Isoproterenol (Isoprenaline)
6.	Epinephrine (Adrenaline)
7.	Phosphorylase a
8.	Hydrocortisone (Cortisol)
9.	Diquat
10.	Deferoxamine (Desferal)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoradiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Transplantation
5.	Injections