Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)

Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.

Also Known As:

GAPD; Dehydrogenase, Glyceraldehyde-3-Phosphate; Dehydrogenase, Glyceraldehydephosphate; Dehydrogenase, Phosphoglyceraldehyde; Dehydrogenase, Triosephosphate; Dehydrogenases, Glyceraldehyde-3-Phosphate; Glyceraldehyde 3 Phosphate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenase; Glyceraldehydephosphate Dehydrogenase; Phosphoglyceraldehyde Dehydrogenase; Triosephosphate Dehydrogenase; D-Glyceraldehyde-3-phosphate:NADP+ oxidoreductase

Networked: 652 relevant articles (6 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on Aldehyde or Oxo Group Donors
      - Aldehyde Oxidoreductases: 1
        Glyceraldehyde-3-Phosphate Dehydrogenases: 652
        Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating): 1
        glyceraldehyde 3-phosphate dehydrogenase (304-313)
        Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
        Glyceraldehyde-3-Phosphate Dehydrogenase (NADP+)(Phosphorylating)
        glyceraldehyde-3-phosphate ferredoxin oxidoreductase
        Phytophthora infestans tigA protein

Experts

1.	Ganapathy-Kanniappan, Shanmugasundaram: 4 articles (12/2018 - 12/2009)
2.	Kunjithapatham, Rani: 4 articles (12/2018 - 12/2009)
3.	Sirover, Michael A: 4 articles (12/2018 - 04/2002)
4.	Muronetz, Vladimir I: 4 articles (07/2017 - 05/2007)
5.	Harada, Naoki: 4 articles (01/2017 - 08/2007)
6.	Yamaji, Ryoichi: 4 articles (10/2015 - 02/2003)
7.	Ferreira, Paula: 3 articles (01/2022 - 11/2011)
8.	Ribeiro, Adília: 3 articles (01/2022 - 11/2011)
9.	Trieu-Cuot, Patrick: 3 articles (01/2022 - 11/2011)
10.	Guzhova, Irina V: 3 articles (02/2021 - 02/2015)

Related Diseases

1.	Infections 11/01/2019 - "Glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma pneumoniae induces infection-related glomerulonephritis ." 01/01/2013 - "Role of cytosolic glyceraldehyde-3-phosphate dehydrogenase in visceral organ infection by Leishmania donovani." 01/01/2002 - "Conclusions: Human liver GAPD may play significant biological roles in addition to glycolysis, especially in signal transduction and in intracellular processes possibly involved in HBV infection." 11/01/2001 - "Immunisation with Salmonella typhimurium-delivered glyceraldehyde-3-phosphate dehydrogenase protects mice against challenge infection with Echinococcus multilocularis eggs." 10/01/2016 - "Studies in the past have either employed cellular β-actin (BACT) or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as internal reference genes, although the stability of their expression in the context of Marek's disease virus (MDV) infection has never been investigated. "
2.	Neoplasms (Cancer) 01/01/2019 - "Our study aims to investigate the impact of nuclear glyceraldehyde-3-phosphate dehydrogenase (GAPDH) on HSCs under hypoxic conditions and the association of nuclear GAPDH with HCC patient outcomes and tumor progression. " 12/01/2009 - "In the current study, using radiolabeled ((14)C) 3BrPA in multiple cancer cell lines, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified as the primary intracellular target of 3BrPA, based on two-dimensional (2D) gel electrophoretic autoradiography, mass spectrometry and immunoprecipitation. " 04/29/2020 - "Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors." 01/01/2019 - "Combination index analysis and xenograft animal model were conducted to explore the effects of combination of inhibitors of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and oxidative phosphorylation on tumor growth. " 01/01/2018 - "The crucial intermediate component of glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), could play a significant role in cancer progression. "
3.	Ureteral Obstruction 08/01/2011 - "28S-ribosomal RNA is superior to glyceraldehyde-3-phosphate dehydrogenase as a RNA reference gene in p53-deficient mice with unilateral ureteral obstruction." 10/01/2004 - "Renal TNF-alpha mRNA expression and protein production peaked following 3 days of ureteral obstruction (54 +/- 5% vs sham 22 +/- 9% of glyceraldehyde-3-phosphate dehydrogenase mRNA, p <0.05 and 204 +/- 13 vs sham 84 +/- 9 pg/ml, p <0.05, respectively). "
4.	Pneumonia (Pneumonitis) 12/15/2015 - "The lopinavir/ritonavir-treated and interferon-β1b-treated animals had better outcome than the untreated animals, with improved clinical (mean clinical scores ↓50.9%-95.0% and ↓weight loss than the untreated animals), radiological (minimal pulmonary infiltrates), and pathological (mild bronchointerstitial pneumonia) findings, and lower mean viral loads in necropsied lung (↓0.59-1.06 log10 copies/glyceraldehyde 3-phosphate dehydrogenase [GAPDH]; P < .050) and extrapulmonary (↓0.11-1.29 log10 copies/GAPDH; P < .050 in kidney) tissues. "
5.	Headache (Headaches) 08/01/2011 - "Patients with CH had significantly increased relative IL-2 gene expression levels between headache attacks during active CH period (median 9.9 IL-2 cDNA/glyceraldehyde-3-phosphate dehydrogenase cDNA; IQR 6.2-10.3) compared to during attacks (median 2.8; IQR 0.7-3.2, P = 0.012), remission (median 1.6; IQR 0.9-1.8, P = 0.017) and controls (median 0.9; IQR 0.6-1.9, P = 0.0001). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Enzymes
3.	Ribosomal Proteins (Ribosomal Protein)
4.	RNA (Ribonucleic Acid)
5.	Interleukin-2 (IL2)
6.	Small Interfering RNA (siRNA)
7.	Complementary DNA (cDNA)
8.	Vaccines
9.	Lopinavir
10.	Ritonavir (Norvir)

Related Therapies and Procedures

1.	Therapeutics
2.	Cell- and Tissue-Based Therapy (Cell Therapy)
3.	Enzyme Replacement Therapy
4.	Hematopoietic Stem Cell Transplantation
5.	Cardiopulmonary Resuscitation (CPR)