Glutathione Transferase (Glutathione S-Transferase)

A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Also Known As:
Glutathione S-Transferase; Transferase, Glutathione; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Transferase 3; Glutathione S-Transferase A; Glutathione S-Transferase B; Glutathione S-Transferase C; Glutathione S-Transferase III; Glutathione S-Transferase P; Glutathione Transferase E; Glutathione Transferase mu; Glutathione Transferases; Heme Transfer Protein; Ligandin; Yb-Glutathione-S-Transferase; Glutathione Lyase, S-Hydroxyalkyl; Glutathione S Alkyltransferase; Glutathione S Aryltransferase; Glutathione S Epoxidetransferase; Glutathione S Transferase; Glutathione S Transferase 3; Glutathione S Transferase A; Glutathione S Transferase B; Glutathione S Transferase C; Glutathione S Transferase III; Glutathione S Transferase P; Lyase, S-Hydroxyalkyl Glutathione; P, Glutathione S-Transferase; Protein, Heme Transfer; S Hydroxyalkyl Glutathione Lyase; S-Alkyltransferase, Glutathione; S-Aryltransferase, Glutathione; S-Epoxidetransferase, Glutathione; S-Transferase 3, Glutathione; S-Transferase A, Glutathione; S-Transferase B, Glutathione; S-Transferase C, Glutathione; S-Transferase III, Glutathione; S-Transferase P, Glutathione; S-Transferase, Glutathione; Transfer Protein, Heme; Transferase E, Glutathione; Transferase mu, Glutathione; Transferases, Glutathione; Glutathione S-Alkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Ligandins; S-Hydroxyalkyl Glutathione Lyase; RX:glutathione R-transferase
Networked: 2935 relevant articles (39 outcomes, 357 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Fukushima, Shoji: 13 articles (11/2011 - 08/2003)
2. Sultana, Sarwat: 12 articles (09/2013 - 08/2004)
3. Saadat, Mostafa: 10 articles (11/2014 - 06/2006)
4. Fryer, A A: 10 articles (02/2005 - 01/2000)
5. Strange, R C: 10 articles (02/2005 - 01/2000)
6. Ali-Osman, Francis: 9 articles (12/2015 - 04/2003)
7. Peters, Wilbert H M: 9 articles (09/2013 - 03/2002)
8. Nelson, William G: 8 articles (01/2014 - 01/2002)
9. Ranson, Hilary: 8 articles (01/2014 - 08/2003)
10. Mitsumori, Kunitoshi: 8 articles (09/2012 - 08/2004)

Related Diseases

1. Neoplasms (Cancer)
01/01/2010 - "Out of the single gene perturbations, activation of glutathione S-transferase P (GSTP1) gene was by far the most effective in blocking the cancer phenotype. "
05/01/2006 - "The 24-mo fermentation was the most effective in preventing cancer by decreasing tumor formation and increasing natural killer cell activity in spleens and glutathione S-transferase activity in livers of mice. "
04/12/1996 - "In search of compounds with improved specificity for targeting the important cancer-associated P1-1 glutathione S-transferase (GST) isozyme, new analogs 4 and 5 of the previously reported glutathione S-transferase (GST)-activated latent alkylating agent gamma-glutamyl-alpha-amino-beta-[[[2-[[bis[bis(2-chloroethyl)amino]ph osp horyl]oxy]ethyl]sulfonyl]propionyl]-(R)-(-)-phenylglycine (3) have been designed, synthesized, and evaluated. "
01/07/2015 - "The 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX, 1), a "suicide inhibitor" of the glutathione-S-transferase GSTP1-1, showed pro-apoptotic properties in tumor cells, but in vivo studies were limited by poor bioavailability and high affinity towards GSTM2-2, expressed in many non-cancerous tissues. "
01/01/2015 - "In this study, we searched for novel binding partners of the influenza A virus NS2 protein, the nuclear export protein responsible for overcoming host range restriction, by a yeast two-hybrid screening assay and glutathione S-transferase-pulldown and coimmunoprecipitation assays and identified AIMP2, a potent tumor suppressor that usually functions to regulate protein stability, as one of the major NS2-binding candidates. "
2. Infection
3. Body Weight (Weight, Body)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Inflammation

Related Drugs and Biologics

1. Glutathione (Reduced Glutathione)
2. Enzymes
3. Glutathione Peroxidase
4. Glutathione Reductase (Glutathione-Disulfide Reductase)
5. Proteins (Proteins, Gene)
6. Superoxide Dismutase
7. Catalase
8. Cytochrome P-450 Enzyme System (Cytochrome P450)
9. Cytochromes
10. O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Transplantation (Transplant Recipients)
3. Aftercare (After-Treatment)
4. Adjuvant Chemotherapy
5. Homologous Transplantation (Allograft)