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Glutathione Transferase (Glutathione S-Transferase)

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A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.

Also Known As:

Glutathione S-Transferase; Transferase, Glutathione; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Transferase 3; Glutathione S-Transferase A; Glutathione S-Transferase B; Glutathione S-Transferase C; Glutathione S-Transferase III; Glutathione S-Transferase P; Glutathione Transferase E; Glutathione Transferase mu; Glutathione Transferases; Heme Transfer Protein; Ligandin; Yb-Glutathione-S-Transferase; Glutathione Lyase, S-Hydroxyalkyl; Glutathione S Alkyltransferase; Glutathione S Aryltransferase; Glutathione S Epoxidetransferase; Glutathione S Transferase; Glutathione S Transferase 3; Glutathione S Transferase A; Glutathione S Transferase B; Glutathione S Transferase C; Glutathione S Transferase III; Glutathione S Transferase P; Lyase, S-Hydroxyalkyl Glutathione; P, Glutathione S-Transferase; Protein, Heme Transfer; S Hydroxyalkyl Glutathione Lyase; S-Alkyltransferase, Glutathione; S-Aryltransferase, Glutathione; S-Epoxidetransferase, Glutathione; S-Transferase 3, Glutathione; S-Transferase A, Glutathione; S-Transferase B, Glutathione; S-Transferase C, Glutathione; S-Transferase III, Glutathione; S-Transferase P, Glutathione; S-Transferase, Glutathione; Transfer Protein, Heme; Transferase E, Glutathione; Transferase mu, Glutathione; Transferases, Glutathione; Glutathione S-Alkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Ligandins; S-Hydroxyalkyl Glutathione Lyase; RX:glutathione R-transferase

Networked: 2935 relevant articles (39 outcomes, 357 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Alkyl and Aryl Transferases: 2
      - Glutathione Transferase: 2935
        glutathione S-transferase M1: 405
        Glutathione S-Transferase pi: 349
        glutathione S-transferase T1: 173
        glutathione S-transferase alpha: 90
        leukotriene-C4 synthase: 35
        glutathione S-transferase Mu 2: 2
        glutathione transferase M3-3: 2
        sulfobromophthalein-glutathione conjugase: 2
        glutathione S-transferase 9.5-2: 1
        glutathione S-transferase Yc: 1
        mGSTA4-4: 1
        Arabidopsis DHAR1 protein
        Arabidopsis GST1 protein
        Arabidopsis GST11 protein
        Arabidopsis GSTF2 protein
        Arabidopsis GSTF6 protein
        Arabidopsis GSTF8 protein
        Arabidopsis GSTF9 protein
        Arabidopsis GSTU19 protein
        Arabidopsis GSTU26 protein
        Arabidopsis GSTZ1 protein
        Arabidopsis TRANSPARENT TESTA 19 protein
        C elegans GSTO-1 protein
        Culicoides variipennis sonorensis cvgst1 protein
        cyanocobalamin beta-ligand transferase
        Drosophila GstE1 protein
        E coli YfcF protein
        E coli YfcG protein
        glutathione S-transferase 9.5-1
        human glutathione S-transferase A3-3
        human glutathione S-transferase M5
        human glutathione transferase T1-1
        human GSTA1 protein
        human GSTK1 protein
        human GSTM3 protein
        human GSTM4 protein
        human GSTO1 protein
        human GSTO2 protein
        human GSTT2 protein
        human GSTZ1 protein
        MdGST-6A
        microsomal glutathione S-transferase-I
        mouse glutathione S-transferase M5
        mouse GSTA4-4 protein
        mouse Gsto1 protein
        mouse Gstt2 protein
        mouse Gstz1 protein
        Octopus S-crystallin protein
        Plasmodium falciparum GST1 protein
        rat glutathione transferase 5-5
        rat Gstt2 protein
        rat Gstz1 protein
        rat kappa glutathione S-transferase 1-1
        recombinant GST-Nef protein
        recombinant GST-RAP protein
        S cerevisiae 1-Cys thiol transferase protein
        Schistosoma haematobium 28 kDa gluthathione S-transferase antigen
        Schistosoma mansoni 28-kilodalton glutathione S-transferase antigen
        Xenopus glutathione transferase sigma
        Xenopus GSTM1-1 protein

Experts

1.	Fukushima, Shoji: 13 articles (11/2011 - 08/2003)
2.	Sultana, Sarwat: 12 articles (09/2013 - 08/2004)
3.	Saadat, Mostafa: 10 articles (11/2014 - 06/2006)
4.	Fryer, A A: 10 articles (02/2005 - 01/2000)
5.	Strange, R C: 10 articles (02/2005 - 01/2000)
6.	Ali-Osman, Francis: 9 articles (12/2015 - 04/2003)
7.	Peters, Wilbert H M: 9 articles (09/2013 - 03/2002)
8.	Nelson, William G: 8 articles (01/2014 - 01/2002)
9.	Ranson, Hilary: 8 articles (01/2014 - 08/2003)
10.	Mitsumori, Kunitoshi: 8 articles (09/2012 - 08/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2010 - "Out of the single gene perturbations, activation of glutathione S-transferase P (GSTP1) gene was by far the most effective in blocking the cancer phenotype. " 05/01/2006 - "The 24-mo fermentation was the most effective in preventing cancer by decreasing tumor formation and increasing natural killer cell activity in spleens and glutathione S-transferase activity in livers of mice. " 04/12/1996 - "In search of compounds with improved specificity for targeting the important cancer-associated P1-1 glutathione S-transferase (GST) isozyme, new analogs 4 and 5 of the previously reported glutathione S-transferase (GST)-activated latent alkylating agent gamma-glutamyl-alpha-amino-beta-[[[2-[[bis[bis(2-chloroethyl)amino]ph osp horyl]oxy]ethyl]sulfonyl]propionyl]-(R)-(-)-phenylglycine (3) have been designed, synthesized, and evaluated. " 01/07/2015 - "The 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX, 1), a "suicide inhibitor" of the glutathione-S-transferase GSTP1-1, showed pro-apoptotic properties in tumor cells, but in vivo studies were limited by poor bioavailability and high affinity towards GSTM2-2, expressed in many non-cancerous tissues. " 01/01/2015 - "In this study, we searched for novel binding partners of the influenza A virus NS2 protein, the nuclear export protein responsible for overcoming host range restriction, by a yeast two-hybrid screening assay and glutathione S-transferase-pulldown and coimmunoprecipitation assays and identified AIMP2, a potent tumor suppressor that usually functions to regulate protein stability, as one of the major NS2-binding candidates. "
2.	Infection 01/01/1992 - "Sm28, a glutathione-S-transferase, induces significant protection against schistosome infection in rodents and nonhuman primates. " 02/01/2003 - "The efficacy of the Be82 gene product fused with glutathione S-transferase (GST/Be82) in an enzyme-linked immunosorbent assay (ELISA) for the diagnosis of Babesia equi infection was reported previously (H. " 11/01/2015 - "Neither the phi glutathione S-transferase (GST)-encoding gene expression nor the GST (EC 2.5.1.13) activity was modified upon wheat infection by powdery mildew. " 06/01/2015 - "Trichinella spiralis: low vaccine potential of glutathione S-transferase against infections in mice." 02/01/2015 - "Catalytic features and crystal structure of a tau class glutathione transferase from Glycine max specifically upregulated in response to soybean mosaic virus infections."
3.	Body Weight (Weight, Body) 05/01/1987 - "SKF525-A given intraperitoneally (50 mg/kg body weight) to Sprague-Dawley rats in a single dose promoted a significant reduction in cytosolic glutathione S-transferase (GST) activities 0.5 and 1 h after injection. " 07/01/2008 - "Occurrence of glutathione S-transferase placental form (GST-P)-positive hepatocytes was examined, using 15 Wistar rats of both sexes each orally administered 2,3,7,8-tetrabromo-dibenzo-p-dioxin (TBDD) by gavage at a single dose of 0, 10, 30, 100 or 300 microg/kg body weight. " 11/01/2001 - "Body weight, lung weight and tissue glutathione-S-transferase activity were, however, not altered. " 11/01/1997 - "The volume fraction of the liver occupied by glutathione S-transferase P-positive foci was significantly increased to 2.9, 3.3, and 12% at 300, 1500, and 7500 microg/kg body weight/week, respectively, compared to 1.2% in the controls. " 01/01/1996 - "CHL [50, 100, or 200 mg/kg body weight (b.w.)/day] induced significant increases in the hepatic levels of glutathione S-transferase (GST) and sulfhydryl (-SH) in lactating dams and suckling pups of 14 or 21 days. "
4.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2012 - "Previous studies investigating the association between the glutathione S-transferase Tl (GSTT1) null genotype and colorectal cancer (CRC) risk in the Asian population have reported controversial results. " 09/01/2014 - "Epigenetic alterations are involved in the overexpression of glutathione S-transferase π-1 in human colorectal cancers." 06/01/2014 - "To investigate the correlation between glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and colorectal cancer (CRC) risk. " 06/01/2014 - "A systemic review of glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk." 01/01/2014 - "Cruciferous vegetables, glutathione S-transferase polymorphisms, and the risk of colorectal cancer among Chinese men."
5.	Inflammation 05/01/2013 - "The glutathione S-transferase P1 Ile105Val polymorphism markedly modifies allergen-provoked airway inflammation in atopic asthmatics in vivo. " 05/01/2013 - "Yet, little remains known about the regulation of allergic inflammation by glutathione S-transferase P1 in human asthmatics. " 05/01/2013 - "Glutathione S-transferase P1 Ile105Val polymorphism modulates allergen-induced airway inflammation in human atopic asthmatics in vivo." 01/01/2013 - "At sacrifice, the livers of SD rats treated with DEN and HFD exhibited marked development of glutathione S-transferase placental form (GST-P)-positive foci, a hepatic preneoplastic lesion, and this was associated with hepatic steatosis, oxidative stress and inflammation, and hepatocyte proliferation. " 05/01/2012 - "Urine α-Glutathione S-transferase, systemic inflammation and arterial function in juvenile type 1 diabetes."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Enzymes
3.	Glutathione Peroxidase
4.	Glutathione Reductase (Glutathione-Disulfide Reductase)
5.	Proteins (Proteins, Gene)
6.	Superoxide Dismutase
7.	Catalase
8.	Cytochrome P-450 Enzyme System (Cytochrome P450)
9.	Cytochromes
10.	O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation (Transplant Recipients)
3.	Aftercare (After-Treatment)
4.	Adjuvant Chemotherapy
5.	Homologous Transplantation (Allograft)