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Glutathione Reductase (Glutathione-Disulfide Reductase)

Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.
Also Known As:
Glutathione-Disulfide Reductase; Reductase, Glutathione; Reductase, Glutathione-Disulfide; NADPH:oxidized-glutathione oxidoreductase
Networked: 1181 relevant articles (30 outcomes, 108 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Popova, T N: 12 articles (01/2018 - 06/2002)
2. Feng, Lin: 11 articles (01/2020 - 08/2015)
3. Jiang, Wei-Dan: 11 articles (01/2020 - 08/2015)
4. Liu, Yang: 11 articles (01/2020 - 08/2015)
5. Wu, Pei: 11 articles (01/2020 - 08/2015)
6. Zhou, Xiao-Qiu: 11 articles (01/2020 - 08/2015)
7. Jiang, Jun: 10 articles (01/2020 - 08/2015)
8. Kuang, Sheng-Yao: 10 articles (06/2019 - 08/2015)
9. Tang, Ling: 10 articles (06/2019 - 08/2015)
10. Sultana, Sarwat: 10 articles (09/2013 - 08/2004)

Related Diseases

1. Body Weight (Weight, Body)
2. Hypertension (High Blood Pressure)
01/01/2018 - "In the other three groups, the positive associations of blood pressure with glutathione reductase activity suggest a possible role for adequate glutathione reductase activity in preventing or delaying the development of hypertension."
01/01/2003 - "The aim of this study was to assess the activity of CAT, GSH-Px, SOD and glutathione reductase in children with a family history of premature CHD who did not present any other major risk factors of CHD (diabetes, obesity, dyslipidaemia or hypertension). "
10/01/2015 - "The level in the cytoplasmic and mitochondrial fractions above benchmarks, indicating about the change of antioxidant systems of the body In the cytoplasm and mitochondria of cardiomyocytes of the rats with arterial hypertension marked decrease in the activity of antioxidant enzymes: NO-synthase, catalase, glutathione reductase, which causes metabolic changes of the myocardium."
01/01/2021 - "Abbreviations: HR = hypertensive retinopathy, HTN = hypertension, GSH = reduced glutathione, GPx = glutathione peroxidase, GR = glutathione reductase, GGR = gamma-glutamyl transferase, ROSs = reactive species of oxygen, OS = oxidative stress."
12/01/1982 - " The following are some results: 1) there was a more varied diet among older women, those with higher education, and those with higher income; 2) 29.5% were obese; 3) obese women were less well educated and had lower incomes; 4) hypertension was found in 14 women; 5) 14 women had hemoglobin values below 12 g/1000 ml, 8 had hematocrit values of less than 38%, 6) 75% were low or deficient in plasma folacin values, 7) erythrocyte folacin values were low in 57.5%; erythrocyte glutathione reductase assays for riboflavin status showed 11 women in the deficient range and plasma carotene values were deficient in 2, low in 9; 8) women taking OCs had lower erythrocyte folacin levels but higher plasma retinol levels; and 9) the more children a woman was raising the poorer was her riboflavin status. "
3. Neoplasms (Cancer)
4. Hypoxia (Hypoxemia)
5. Insulin Resistance
11/01/2011 - "The combination groups proved to be effective in normalizing the levels of superoxide dismutase, catalase, glutathione reductase and lipid peroxidation in liver homogenates may be due to antioxidant effects of melatonin and decreased hyperglycemia induced insulin resistance by thiazolidinediones. "
01/01/2013 - "We analyzed (a) insulin sensitivity (IS) and (b) glutathione peroxidase (GSH-Px), glutathione reductase (GR), and superoxide dismutase (SOD) antioxidant enzyme activity in type 2 diabetic (T2D) patients with atherothrombotic infarction (ATI) (group A), lacunar infarction (LI) (B), or without stroke (C) and in nondiabetics with ATI (D), LI (E), or without stroke (F). "
01/01/2013 - "Fasting serum levels of 25-OH-D, calcium, phosphorous, parathyroid hormone, glucose, HbA(1C), insulin, homeostasis model assessment of insulin resistance index, total antioxidant capacity (TAC), activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GSH-PX) were measured. "
04/29/2021 - "Chronic drinking when combined with HFD was associated with reduced body weight, fat accumulation and serum TNF-α level, serum TG, TC and LDL-C levels, and improved glucose tolerance (OGTT) and insulin sensitivity (ITT), hepatic enzymes; elevated levels or activities of the antioxidant enzymes like superoxide dismutase, catalase and glutathione reductase, reduced the content of lipid peroxidation productions such as malondialdehyde, in comparison with the pure HFD intake. "
01/01/2022 - "According to the previous studies, polydatin is a versatile natural compound and exerts significantly protective and curative effects on oxidative stress-associated liver diseases via various molecular mechanisms, including amelioration of liver function and insulin resistance, inhibition of proinflammatory cytokines, lipid accumulation, endoplasmic reticulum stress and autophagy, regulation of PI3K/Akt/mTOR, and activation of hepatic stellate cells (HSCs), as well as increase of antioxidant enzymes (such as catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), superoxide dismutase (SOD), glutathione reductase (GR), and heme oxygenase-1 (HO-1)). "

Related Drugs and Biologics

1. Antioxidants
2. Superoxide Dismutase
3. Catalase
4. Glutathione Peroxidase
5. Glutathione (Reduced Glutathione)
6. Enzymes
7. Glutathione Transferase (Glutathione S-Transferase)
8. Malondialdehyde (Propanedial)
9. Ascorbic Acid (Vitamin C)
10. Vitamin E

Related Therapies and Procedures

1. Oral Administration
2. Lenses
3. Chemoprevention
4. Therapeutics
5. Drug Therapy (Chemotherapy)