Glutathione (Reduced Glutathione)

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Also Known As:

Networked: 8368 relevant articles (298 outcomes, 984 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Park, Woo Hyun: 29 articles (01/2016 - 11/2008)
2.	Kumar, Anil: 29 articles (12/2015 - 10/2007)
3.	Sener, Göksel: 29 articles (05/2014 - 04/2003)
4.	Sultana, Sarwat: 20 articles (04/2014 - 04/2003)
5.	You, Bo Ra: 19 articles (01/2016 - 07/2009)
6.	Jones, Dean P: 17 articles (05/2015 - 08/2002)
7.	Berk, Michael: 17 articles (01/2015 - 08/2008)
8.	Do, Kim Q: 16 articles (01/2012 - 08/2003)
9.	Cetinel, Sule: 15 articles (05/2014 - 01/2004)
10.	Han, Yong Hwan: 15 articles (07/2010 - 11/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/28/2011 - "The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. " 08/01/2008 - "In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe." 02/01/1999 - "Our results indicate that determination of glutathione status and oxidative stress-related parameters in blood may help to orientate cancer therapy in humans." 10/01/1990 - "Cytoplasts, however, did not kill antibody-coated K562 tumor cells; this was not improved by glutathione depletion but showed some lysis of antibody-coated RBC. " 02/01/1985 - "Under these conditions, the protection against BP-induced lung tumors and perhaps forestomach tumors may be due to an elevation of tissue glutathione, resulting in a decreased binding of reactive metabolites of BP to macromolecules at these sites. "
2.	Body Weight (Weight, Body) 10/01/2008 - "This study aimed to assess the potential efficacy of glutathione monoester (GME) when administered intraperitoneally (12 mg/kg body weight) for 20 days on memory and the antioxidant defense system and lipid peroxidation in discrete brain regions such as cortex, striatum, and hippocampus of young and aged rats. " 07/01/1984 - "The systemic clearance of glutathione was 3.22 +/- 0.51 ml per min X 100 gm body weight. " 05/01/1991 - "The study designs included observations of clinical signs, body weights, major organ weights, gross and histopathological examinations, serum clinical chemistry, and biochemical examinations such as glyoxalase activity and glutathione content in selected tissues. " 11/01/2015 - "On the last prenatal day (Group 1), embryos from OOED group showed smaller body weight, brain weight and lower levels of sulphydryl groups glutathione reduced (GSH) in the brain. " 01/01/2015 - "ICR mice were divided into 4 groups: sedentary control, sedentary supplemented with glutathione (2.0%, 5 μL/g body weight), exercise control, and exercise supplemented with glutathione. "
3.	Inflammation 07/09/2015 - "Notably, EE appeared to offer some protection against the consequences of inflammation on juvenile social behavior and fully prevented reduced glutathione levels in the juvenile prefrontal cortex. " 11/01/2007 - "ALA is beneficial in TNBS-induced gut inflammation in rats via suppression of neutrophil accumulation, preservation of endogenous glutathione and inhibition of reactive oxidant generation." 12/01/2006 - "This beneficial effect was associated with an improvement in the colonic oxidative status, since the infusion prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. " 11/01/2013 - "This study aimed to identify how the interaction between the intracellular antioxidant glutathione peroxidase-1 (GPx-1) and PTP1B affected lung PP2A activity and airway inflammation. " 06/14/2002 - "The findings of this study provide important information, which may be used for the modulation of glutathione biosynthesis in inflammation."
4.	Ischemia 12/01/2011 - "The purpose of this study was to determine if exercise (Ex) protects hearts from arrhythmias induced by glutathione oxidation or ischemia-reperfusion (I/R). " 09/01/2011 - "The present study tested whether osmotic stress is involved in the glutathione depletion during ischemia. " 11/01/2007 - "The in vivo and in vitro ischemia reperfusion studies showed that prophylactic administration of aqueous garlic prior to ischemia reperfusion inhibit lipid peroxidation and prevent depletion in glutathione through its compounds that led to functional recovery. " 07/01/2006 - "In the present study, the impact of elective aorto-bifemoral bypass surgery, involving a longer ischemia time, on muscle glutathione and its redox-status was investigated. " 08/01/2001 - "The present study examined the effects of oral reduced glutathione (GSH) supplementation in conjunction with endurance training on contractile function, antioxidant defense, and oxidative damage in response to ischemia-reperfusion (I/R) in rat hearts. "
5.	Anoxia (Hypoxia) 07/01/1993 - "The results obtained allow us to outline perspectives of search for new compounds controlling the level of glutathione in the cells and, hence, activating the development of adaptational compensatory mechanisms for protection against de-energizing effect of hypoxia and similar factors." 01/01/2013 - "The stimulation of mitochondrial respiration was associated with the induction of mitochondrial uncoupling (27%) and enhancement of cellular glutathione redox cycling as well as protection against hypoxia/reoxygenation (hypox/reoxy)-induced apoptosis (by 60%). " 10/01/2007 - "In this porcine model of neonatal hypoxia and 100% reoxygenation, NAC improved cardiac function and renal perfusion, with improved tissue glutathione content." 03/01/2004 - "These data suggest that acute hypoxia per se might enhance oxidative stress; however, the glutathione system seems to have a modest role in skeletal muscle protection against hypoxia-induced oxidative stress. " 12/01/1988 - "The mechanism by which hypoxia preexposure conferred protection against H2O2 appeared to depend on hexose monophosphate shunt (HMPS)-dependent increases in lung glutathione redox cycle activity. "

Related Drugs and Biologics

1.	Superoxide Dismutase
2.	Catalase
3.	Glutathione Peroxidase
4.	Malondialdehyde (Propanedial)
5.	Cysteine (L-Cysteine)
6.	Enzymes
7.	Ascorbic Acid (Vitamin C)
8.	Acetylcysteine (Siran)
9.	Transferases
10.	Nitric Oxide (Nitrogen Monoxide)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Aftercare (After-Treatment)
4.	Ligation
5.	Lenses