Glucosinolates

Substituted thioglucosides. They are found in rapeseed (Brassica campestris) products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.

Also Known As:

Networked: 411 relevant articles (24 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Iori, Renato: 14 articles (11/2018 - 04/2002)
2.	Abdull Razis, Ahmad Faizal: 9 articles (01/2022 - 06/2011)
3.	Gershenzon, Jonathan: 8 articles (10/2020 - 02/2003)
4.	Mazzon, Emanuela: 7 articles (01/2022 - 01/2016)
5.	Moreno, Diego A: 7 articles (12/2020 - 01/2007)
6.	Schreiner, Monika: 7 articles (04/2018 - 05/2014)
7.	Halkier, Barbara Ann: 7 articles (03/2018 - 06/2006)
8.	Pagnotta, Eleonora: 6 articles (02/2022 - 02/2013)
9.	Reichelt, Michael: 6 articles (10/2020 - 02/2003)
10.	Bisht, Naveen C: 5 articles (10/2021 - 03/2015)

Related Diseases

1.	Neoplasms (Cancer) 02/28/1997 - "Brassicas, including all types of cabbages, broccoli, cauliflower and Brussels sprouts, may be protective against cancer due to their relatively high glucosinolate content. " 10/01/2011 - "Given the variety of ITC produced from glucosinolates, and the diverse pathways on which these compounds act, a systems biology approach, in vivo, may help to better characterize their integrated role in cancer prevention. " 02/01/2007 - "The protective effects of brassica vegetables against cancer may be partly related to their glucosinolate content. " 09/01/2003 - "Evidence indicates that cruciferous vegetables are protective against a range of cancers with glucosinolates and their breakdown products considered the biologically active constituents. " 01/01/1999 - "Brassicas, including all types of cabbages, broccoli, cauliflower, and Brussels sprouts, may be protective against cancer due to their glucosinolate content. "
2.	Infections 10/01/2016 - "The aim of this study was to investigate if Atlantic salmon fed two different doses of glucosinolate-enriched feeds would be protected against lice infection. " 11/08/2021 - "Glucosinolate Bioactivation by Apis mellifera Workers and Its Impact on Nosema ceranae Infection at the Colony Level." 10/01/2021 - "Furthermore, BjuXLG-RNAi lines showed reduced accumulation of leaf glucosinolates on S. sclerotiorum infection, wherein aliphatic glucosinolates were significantly compromised. " 05/06/2021 - "Single among with total aliphatic and total indolic glucosinolate contents were significantly lower in leaves of susceptible cultivars compared to resistant ones due to the infection. " 08/30/2020 - "Glucosinolate Profile and Glucosinolate Biosynthesis and Breakdown Gene Expression Manifested by Black Rot Disease Infection in Cabbage."
3.	Neuralgia (Stump Neuralgia) 01/01/2019 - "The purpose of this study was to evaluate the anti-hyperalgesic efficacy of Eruca sativa defatted seed meal, along with its main glucosinolate, glucoerucin (GER), on diabetic neuropathic pain induced in mice by streptozotocin (STZ). " 11/01/2018 - "Aim of the present work was to study the efficacy of the glucosinolate glucoraphanin (GRA) and the derived isothiocyanate sulforaphane (SFN), secondary metabolites occurring exclusively in Brassicales, on chemotherapy-induced neuropathic pain. "
4.	Chronic Disease (Chronic Diseases) 01/01/2021 - "Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed." 01/01/2021 - "Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence." 12/01/2020 - "Both glucosinolates and isothiocyanates have been described as beneficial for the prevention and improvement of some chronic diseases. " 01/01/2018 - "Glucosinolates (GS) are metabolized to isothiocyanates that may enhance human healthspan by protecting against a variety of chronic diseases. " 05/01/2015 - "Likewise, broccoli contains high levels of glucosinolates, carotenoids and total phenols, which are related with the prevention of chronic diseases. "
5.	Pain (Aches) 01/01/2019 - "Recent data highlighted the pain-relieving efficacy of glucosinolates deriving from Brassicaceae. " 01/01/2019 - "sativa defatted meal (1 g kg-1 p.o.) and GER (100 µmol kg-1 p.o., equimolar to meal content) showed a dose-dependent pain-relieving effect in STZ-diabetic mice, but the meal was more effective than the glucosinolate. " 01/25/2017 - "Broccoli is a rich source of health-promoting glucosinolates, phenolic compounds, minerals and vitamins, which might have potential to alleviate pain. " 02/17/2022 - "Glucosinolates, secondary metabolites mainly of Brassicaceae with anti-inflammatory and neuroprotective properties, are effective in treating both neuropathic and arthritis pain through H2S release and Kv7 potassium channel activation. " 02/03/2021 - "The plant is rich in glucosinolates and isothiocyanates; the latter has been demonstrated to be a strong agonist in vitro of the Transient Receptor Potential Ankirine 1 (TRPA1) channel, which is involved in the somatosensory perception of pungency as well as in the nociception pathway of inflammatory pain. "

Related Drugs and Biologics

1.	Glucosinolates
2.	Isothiocyanates
3.	isothiocyanic acid
4.	sulforaphane
5.	Carotenoids (Carotene)
6.	glucoraphanin
7.	moringin
8.	Polyphenols
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chemoprevention
3.	Oral Administration
4.	Therapeutics
5.	Ovariectomy (Oophorectomy)