Glucosinolates

Substituted thioglucosides. They are found in rapeseed (Brassica campestris) products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.

Networked: 114 relevant articles (6 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Halkier, Barbara Ann: 4 articles (01/2014 - 01/2009)
2.	Olsen, Carl Erik: 3 articles (10/2014 - 01/2009)
3.	Iori, Renato: 3 articles (04/2013 - 12/2006)
4.	Halkier, Barbara A: 3 articles (01/2011 - 03/2003)
5.	Geu-Flores, Fernando: 3 articles (01/2011 - 01/2009)
6.	Halkier, B A: 3 articles (04/2001 - 05/2000)
7.	Wittstock, U: 3 articles (04/2001 - 05/2000)
8.	Schöne, F: 2 articles (06/2015 - 01/2001)
9.	Glatt, Hansruedi: 2 articles (06/2014 - 05/2014)
10.	Schreiner, Monika: 2 articles (06/2014 - 05/2014)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2011 - "Given the variety of ITC produced from glucosinolates, and the diverse pathways on which these compounds act, a systems biology approach, in vivo, may help to better characterize their integrated role in cancer prevention. " 09/01/2003 - "Evidence indicates that cruciferous vegetables are protective against a range of cancers with glucosinolates and their breakdown products considered the biologically active constituents. " 01/01/2004 - "A reduced incidence of different types of cancer has been linked to consumption of Brassica vegetables, and there is evidence that glucosinolates (GSLs) and their hydrolysis products play a role in reducing cancer risk. " 03/17/2010 - "Glucosinolates have received much attention as studies have indicated that a diet rich in them may provide some protection from certain cancers. " 12/15/2005 - "These methods provide facile access to comprehensive analytical data on the major dietary glucosinolates and related metabolites to quantify inputs and metabolic formation of these compounds in cancer prevention and related studies."
2.	Infection 01/01/2014 - "In addition, amt1.1 shows altered levels of aliphatic and indolic glucosinolates and other Trp-related compounds following infection by the necrotroph. " 05/01/1999 - "Indole glucosinolates and IAA may, however, be involved in the development of clubroot disease caused by the obligate biotrophic fungus Plasmodiophora brassicae since the TU3 line had a lower infection rate than the wild type, and lines TU3 and TU8 showed decreased symptom development. " 01/01/1997 - "napus meal ('Dwarf Essex') containing glucosinolates and intact myrosinase, the enzyme responsible for glucosinolate hydrolysis, completely inhibited infection by A. " 09/01/2001 - "The present study is the first to address effects on multiple components of this complex system, including concentrations of individual glucosinolates, product formation, myrosinase isoform distribution and activity, and levels of myrosinase binding proteins during the infection process. " 12/01/2002 - "Herbivory and fungal infection reduced the sucrose concentration of leaves and increased amounts of indole glucosinolates as well as total anthocyanins. "
3.	Autolysis 04/24/2008 - "The isolation of myrosinase complexes in their native form is of great importance for the study of the hydrolysis of glucosinolates under autolysis conditions." 10/01/1977 - "Thiocyanate formation from glucosinolates: a study of the autolysis of allylglucosinolate in Thlaspi arvense L. " 10/01/2014 - "Typical combined levels were 4-7 μmol/g dry wt. The hydrolysis product, 5-phenyloxazolidine-2-thione (barbarin), was detected at similar levels as the precursor glucosinolates after autolysis of fresh watercress in water. " 01/01/2011 - "Indole-3-carbinol (I3C), an autolysis product of glucosinolates present in cruciferous vegetables, and its dimeric derivative (3,3'-DIM) have been indicated as promising agents in preventing the development and progression of breast cancer. " 07/15/2003 - "Indole-3-carbinol (I3C), autolysis product of glucosinolates present in cruciferous vegetables, has been indicated as a promising agent in preventing the development and progression of breast cancer. "
4.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2000 - "Many studies have in fact evidenced that a consumption of vegetable containing glucosinolates could reduce the development of colorectal cancer. " 09/01/1997 - "Epidemiological and pharmacological studies have shown that colorectal cancer development could be reduced by consuming vegetables that contain glucosinolates. " 09/01/1995 - "We hypothesize that these enhanced detoxification enzyme levels may partly explain the epidemiological association between a high intake of glucosinolates (cruciferous vegetables) and a decreased risk of colorectal cancer." 03/01/2007 - "Cruciferous vegetables are a rich source of glucosinolates and their hydrolysis products, including indoles and isothiocyanates, and high intake of cruciferous vegetables has been associated with lower risk of lung and colorectal cancer in some epidemiological studies. "
5.	Body Weight (Weight, Body) 12/01/1990 - "In a trial with 50 fattening pigs (20 kg initial body weight), the effect of untreated rapeseed meal (RSM) (148 mmol glucosinolates and aglucones per kg dry matter) on the thyroid was compared with RSM treated with Cu2+ (9.5 mmol glucosinolates and aglucones per kg dry matter) and soybean meal (SBM). " 04/01/2007 - "After 48 h of abstaining from all sources of glucosinolates, participants provided a blood sample, consumed 1 meal containing 2.5 g broccoli/kg body weight, and collected urine for 24 h. " 05/20/2014 - "striolata adults selectively accumulate glucosinolates from their food plants to up to 1.75% of their body weight and express their own myrosinase. "

Related Drugs and Biologics

1.	Isothiocyanates
2.	Carotenoids (Carotene)
3.	Sulfur
4.	Amino Acids
5.	polyphenols
6.	Phytochelatins
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Peptides
9.	Glutathione (Reduced Glutathione)
10.	Cadmium

Related Therapies and Procedures

1.	Activities of Daily Living (ADL)