HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)

An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Also Known As:
Phosphoglucose Isomerase; Glucose 6 Phosphate Isomerase; Glucosephosphate Isomerase; Autocrine Motility Factor; Isomerase, Glucose 6 Phosphate; Neuroleukin; Tumor Autocrine Motility Factor; Tumor-Cell Autocrine Motility Factor; Factor, Autocrine Motility; Isomerase, Glucose-6-Phosphate; Isomerase, Glucosephosphate; Isomerase, Phosphoglucose; Isomerase, Phosphohexose; Motility Factor, Autocrine; Tumor Cell Autocrine Motility Factor; Phosphohexose Isomerase; D-Glucose-6-phosphate ketol-isomerase
Networked: 489 relevant articles (11 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Raz, Avraham: 27 articles (10/2020 - 04/2002)
2. Matsumoto, Isao: 16 articles (03/2020 - 04/2002)
3. Kamradt, Thomas: 14 articles (01/2021 - 04/2004)
4. Sumida, Takayuki: 14 articles (03/2020 - 04/2003)
5. Funasaka, Tatsuyoshi: 14 articles (07/2009 - 04/2002)
6. Haga, Arayo: 11 articles (11/2010 - 04/2002)
7. Inoue, Asuka: 10 articles (11/2019 - 01/2008)
8. Yanagawa, Takashi: 8 articles (12/2012 - 04/2004)
9. Goto, Daisuke: 8 articles (01/2012 - 10/2004)
10. Raz, A: 8 articles (08/2005 - 01/2000)

Related Diseases

1. Arthritis (Polyarthritis)
2. Neoplasms (Cancer)
3. Carcinoma (Carcinomatosis)
4. Breast Neoplasms (Breast Cancer)
5. Neoplasm Metastasis (Metastasis)

Related Drugs and Biologics

1. Enzymes
2. L-Lactate Dehydrogenase (Lactate Dehydrogenase)
3. Peptides (Polypeptides)
4. Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)
5. Hexokinase
6. Autoantigens
7. Ligands
8. Imatinib Mesylate (Gleevec)
9. nilotinib
10. Phosphofructokinases

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Immunotherapy
3. Therapeutics
4. Radiotherapy
5. Ketogenic Diet