Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)

An enzyme that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate, and is a part of the glycolytic and gluconeogenic pathways. Deficiency of the enzyme, an autosomal recessive trait, results in liver glycogenesis and hemolytic anemia. EC 5.3.1.9.

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Networked: 267 relevant articles (8 outcomes, 20 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Matsumoto, Isao: 13 articles (01/2015 - 04/2002)
2.	Sumida, Takayuki: 11 articles (01/2015 - 04/2003)
3.	Kamradt, Thomas: 10 articles (01/2014 - 04/2004)
4.	Raz, Avraham: 9 articles (05/2011 - 10/2002)
5.	Goto, Daisuke: 8 articles (01/2012 - 10/2004)
6.	Inoue, Asuka: 8 articles (01/2012 - 01/2008)
7.	Ito, Satoshi: 7 articles (06/2011 - 10/2004)
8.	Sumida, T: 6 articles (08/2014 - 07/2006)
9.	Matsumoto, I: 6 articles (08/2014 - 07/2006)
10.	Iwanami, Keiichi: 6 articles (01/2012 - 01/2008)

Related Diseases

1.	Arthritis (Polyarthritis) 01/01/2012 - "Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis." 04/01/2004 - "In this study, we show that immunization with the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI) induces severe peripheral symmetric polyarthritis in normal mice. " 01/08/2015 - "In spite of good exposure, twice-a-day treatment with 17l in the glucose-6-phosphate isomerase chronic in vivo mouse model of arthritis yielded only moderate efficacy. " 01/01/2015 - "We herein analyzed the roles of PADI4 in inflammatory arthritis using a glucose-6-phosphate isomerase (GPI)-induced arthritis (GIA) model in Padi4 knockout (KO) mice. " 08/01/2014 - "Therefore, using a glucose-6-phosphate isomerase (GPI)-induced model of arthritis, we investigated these aspects of HC gp-39 in arthritis. "
2.	Neoplasms (Cancer) 09/01/1982 - "The object of this study was to examine if there exists, analogously to what happens in human cancer patients, elevation of phosphohexose isomerase activity (PHI, EC 5.3.1.9) in the serum of animals bearing an experimental tumor and, if so, whether such increases were related to the progress of the tumor, as in humans. " 12/01/1974 - "A clinico-biochemical study of phosphohexose-isomerase, aliesterase and sulfhydryl group, in 25 normal and 35 cancer suspects." 11/01/1991 - "The activities of phosphofructokinase and phosphohexose isomerase were significantly lower in tumors from patients whose disease had superficially invaded the lamina propria (stage pT1) than in others in whom it was confined to the bladder mucosa (stage pTa). " 07/01/1991 - "[Detection of early tumor reactions in irradiation of tumors of the gastrointestinal tract by measuring the onco-radiogenic enzyme peak of glucosephosphate isomerase]." 03/01/1991 - "Glucosephosphate isomerase (GPI), also known as phosphohexoisomerase, is a glycolytic enzyme whose activity is elevated in serum and CSF of patients with primary and metastatic CNS tumors. "
3.	Carcinoma (Carcinomatosis) 01/01/1968 - "A trial of phosphohexose isomerase as a means of detecting cervical carcinoma." 07/01/1991 - "In 43 patients with oesophageal, pancreatic and rectal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. " 01/01/1991 - "In 20 patients with oesophageal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. " 01/01/1991 - "Blood samples were taken from 39 patients with head and neck carcinomas after the initial irradiation, and the activity of the glycolytic enzyme glucose-6-phosphate isomerase (GPI) was measured. " 07/01/1966 - "Possible use of phosphohexose isomerase as a preliminary to exfoliative cytology in screening for cervical carcinoma."
4.	Hemolytic Anemia 05/01/2003 - "Glucosephosphate isomerase (GPI) deficiency in humans is an autosomal recessive disorder, which results in nonspherocytic hemolytic anemia of variable clinical expression. " 12/01/1997 - "Five unrelated patients with hereditary glucosephosphate isomerase (GPI) deficiency resulting in nonspherocytic hemolytic anemia were studied. " 12/01/1997 - "Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA)." 10/01/1993 - "Glucosephosphate isomerase (GPI) deficiency is an unusual cause of hereditary nonspherocytic hemolytic anemia. " 01/01/1990 - "[Hereditary nonspherocytic hemolytic anemia caused by deficiency of erythrocytic glucosephosphate isomerase]."
5.	Breast Neoplasms (Breast Cancer) 05/15/1987 - "[Prognostic significance of serum phosphohexose isomerase in metastatic breast cancer]." 01/01/1997 - "Evaluation of phosphohexose isomerase as a metastasis marker in breast cancer patients." 01/01/1990 - "The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer." 01/01/1986 - "The activity of phosphohexose isomerase [PHI] was measured in 48 primary carcinomas from patients with breast cancer, and its usefulness as a predictor of response to cytotoxic drugs at the metastatic stage was evaluated. " 05/01/2011 - "Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells."

Related Drugs and Biologics

1.	Enzymes
2.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
3.	Hexokinase
4.	4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib)
5.	imatinib (Gleevec)
6.	Alanine Transaminase (SGPT)
7.	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)
8.	Triose-Phosphate Isomerase (Triosephosphate Isomerase)
9.	fingolimod (FTY720)
10.	Transketolase

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Adjuvant Chemotherapy
4.	Mastectomy (Mammectomy)