Glucose-6-Phosphatase (Glucose 6 Phosphatase)

10/01/2010 - "Body weight, liver and muscle glycogen levels, and hepatic glucose-6-phosphatase activity were determined at 25 d of incubation, at hatch, and at 3 and 7 d posthatch. "
06/01/1998 - "However, obese gene product administration to ob/ob mice, while reducing the body weight, did not alter the glucose-6-phosphatase activity."
01/01/1986 - "Thyroxine (T4) in a dose of 0.1 microgram per g body weight caused in the rat a significant increase in hepatic glucose-6-phosphatase activity, while a reduction of this enzyme activity was observed after 1 microgram of T4 per g. "
12/01/1983 - "A single sc administration of CT (synthetic [A1,7] eel CT; 80 MRC mU/100 g body weight) produced significant increases in calcium content and glucose-6-phosphatase activity in the hepatic microsomes of intact and thyroparathyroidectomized rats. "
04/01/1983 - "A single sc administration of CT (80 MRC mU/100 g body weight) produced a significant increase in microsomal calcium content and a corresponding elevation of microsomal glucose-6-phosphatase activity. "

09/01/2007 - "Abnormal expression of the hepatic gluconeogenic genes (glucose-6-phosphatase [G6Pase] and PEPCK) contributes to hyperglycemia. "
10/01/1990 - "Elucidation of the effects of diabetes on the components of the glucose-6-phosphatase system associated with smooth and rough endoplasmic reticulum membranes enhances our understanding of the hepatic contribution to diabetic hyperglycemia."
08/15/1998 - "To examine the mechanisms responsible for the lack of inhibition of EGP by hyperglycemia in DM2 we also assessed the rates of total glucose output (TGO), i.e., flux through glucose-6-phosphatase, and the rate of glucose cycling in a subgroup of the study subjects. "
01/01/2013 - "Moderate postprandial hyperglycemia, strong induction of hepatic glucokinase and repressed glucose-6-phosphatase transcripts confirmed the metabolic response of both lines to carbohydrate intake. "
06/01/2003 - "Dysregulation of G6P in diabetes by changes in activity of glucokinase or glucose 6-phosphatase may be a contributing factor to impaired suppression of glycogenolysis by hyperglycemia."

12/01/2011 - "The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. "
02/06/2009 - "In conclusion, overexpression of dnMlx improves glucose intolerance by inhibiting expression not only of lipogenic enzymes but also other important genes such as Glucose-6-phosphatase and Elovl6."
10/15/1999 - "Because P(i) deprivation markedly affects the Na/P(i) co-transporter in kidney and has been related to insulin resistance and glucose intolerance, the effect of a P(i)-deficient diet on the liver microsomal glucose-6-phosphatase (G6Pase) system was investigated. "
02/06/2009 - "Adenoviral overexpression of dnMlx in 25-week-old male C57BL/6J mice reduced hepatic triglyceride contents and improved glucose intolerance by inhibiting expression of Glucose-6-phosphatase and Elovl6 mRNA in addition to lipogenic enzymes. "
11/15/2000 - "343, 393-396] that dietary phosphate deprivation for 2 days up-regulated both the catalytic subunit and the putative glucose-6-phosphate translocase of the rat liver microsomal glucose-6-phosphatase system, suggesting that increased hepatic glucose production might be responsible for the frequent clinical association of hypophosphataemia and glucose intolerance. "

09/01/1990 - "Recent studies of the type 1 glycogen storage diseases, which are human genetic deficiencies that result in impaired glucose-6-phosphatase activity, have greatly increased our understanding of glucose-6-phosphatase. "
01/01/1980 - "Clinical and enzymological studies in a child with type I glycogen storage disease associated with partial deficiency of hepatic glucose-6-phosphatase."
04/01/2015 - "Glycogen storage disease (GSD) type Ia is caused by a deficiency in glucose-6-phosphatase. "
12/10/2012 - "A novel type heterozygous mutation in the glucose-6-phosphatase gene in a Chinese patient with glycogen storage disease Ia."
11/01/2012 - "To investigate the mutation of glucose-6-phosphatase gene (G6PC gene) in a patient with glycogen storage disease Ⅰa. "

04/01/1992 - "Inflammation suppressed cytochrome P-450 activities, but this was not associated with protection against CCl4-promoted liver microsomal injury as assessed by glucose-6-phosphatase activity loss. "
01/01/2009 - "A significant portion of the CD8(+) T cells were islet-specific glucose-6-phosphatase catalytic subunit-related protein specific in both male and female NOD mice and this population was antigen experienced and increased at high levels of islet inflammation. "