Glomus Tumor (Glomus Tumors)

A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.

Also Known As:

Networked: 257 relevant articles (8 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Glomus Tumor (Glomus Tumors)
3.	Neoplasm Metastasis (Metastasis)
4.	Granuloma
5.	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm)

Experts

1.	Dickson, Brendan C: 3 articles (01/2022 - 06/2013)
2.	Stewart, Douglas R: 3 articles (06/2012 - 09/2009)
3.	Antonescu, Cristina R: 2 articles (01/2022 - 01/2020)
4.	Dry, Sarah M: 2 articles (01/2022 - 01/2016)
5.	Zhang, Lei: 2 articles (01/2022 - 01/2020)
6.	Baba, Satoshi: 2 articles (11/2019 - 04/2017)
7.	Iwashita, Toshihide: 2 articles (11/2019 - 04/2017)
8.	Kawasaki, Hideya: 2 articles (11/2019 - 04/2017)
9.	Kosugi, Isao: 2 articles (11/2019 - 04/2017)
10.	Matsushima, Sayomi: 2 articles (11/2019 - 04/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Glomus Tumor:

1.	SynaptophysinIBA 11/08/2017 - "[Endoscopic full-thickness resection of synaptophysin-positive glomus tumor in gastric body: report of a case]." 11/08/2017 - "However, no synaptophysin expression was seen in glomus tumors of other organs.Most" 11/08/2017 - "Results: The gastric glomus tumors were located in the muscularis propria of the antrum and most cases strongly expressed synaptophysin (5/6). " 11/08/2017 - "[Gastric glomus tumors expressing synaptophysin: clinicopathologic and immunohistochemical analyses]." 07/19/2015 - "This unique case and literature review yielded interesting findings and enabled us to postulate that synaptophysin positivity may be indicative of atypical histological features in glomus tumors arising in visceral organs."
2.	CholesterolIBA 05/01/1990 - "When bone erosion occurs, CT can also be helpful in evaluation of the base of the skull to detect and define the extent of these lesions, for example, cholesterol granuloma and glomus tumor." 03/01/1981 - "The following patient with an isolated middle ear cholesterol granuloma presented with signs and symptoms more closely resembling a glomus tumor." 01/01/2017 - "A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor." 03/01/1989 - "MR can be used to further characterize tympanic cavity masses as effusion, glomus tumor, hemorrhage or cholesterol granuloma. " 09/01/2000 - "In this article, characteristic findings of several diseases in the temporal bone, such as, anomaly, cholesteatoma, cholesterol granuloma, glomus tumor and other tumors, are presented."
3.	CollagenIBA 09/01/2015 - "Immunohistochemistry confirmed the epithelioid cells to be strongly positive for smooth muscle actin, CD34, and type 4 collagen, which is consistent with the phenotype of a glomus tumor. " 10/01/2022 - "Markers such as SMA (juxtaglomerular tumors: 12/13, 92%; glomus tumors: 9/9, 100%), CD34 (juxtaglomerular tumors: 14/14, 100%; glomus tumors: 7/9, 78%), and collagen IV (juxtaglomerular tumors: 5/6, 83%; glomus tumors: 3/3, 100%) were not helpful in separating these entities. " 01/01/2008 - "Glomangiomas are rare, vascular tumors consisting of an afferent artery, arteriovenous canal, neuro-reticular elements, collagen, and efferent veins, and are most often located in the soft tissue of the upper extremities. " 07/01/1997 - "The largest dimension of the tumor occluding the vein was 14 cm. Tumor cells were characterized immunohistochemically by the presence of vimentin, alpha-smooth-muscle actin, and collagen IV. Intravascular spread of the glomus tumor is rare and has been described in the stomach and subcutaneous tissue. " 10/01/2022 - "Herein, we studied the clinicopathologic features of a large series of juxtaglomerular tumors (n = 15) and glomus tumors of the kidney (n = 9) to identify features helpful in their separation, including immunohistochemistry for smooth muscle actin (SMA), CD34, collagen IV, CD117, GATA3, synaptophysin, and renin. "
4.	ReninIBA 11/01/2022 - "Thirteen JXGs and 10 glomus tumors (GTs), a histologic mimic, were evaluated for clinicopathologic features; TCGA data were analyzed to identify non-JXG renin-overexpressing tumors. " 10/01/2022 - "Our results show that juxtaglomerular tumors have a younger age at presentation (median age: 27 years), female predilection, and frequently exhibit diffuse positivity for renin (10/10, 100%) and GATA3 (7/9, 78%), in contrast to glomus tumors (median age: 51 years; renin: 0/6, 0%; GATA3: 0/6, 0%). " 10/01/2022 - "Immunohistochemical expression of renin and GATA3 help distinguish juxtaglomerular cell tumors from renal glomus tumors." 12/01/2003 - "In contrast, all glomus tumors were negative for renin and all hemangiopericytomas were negative for actin. " 10/01/2022 - "Herein, we studied the clinicopathologic features of a large series of juxtaglomerular tumors (n = 15) and glomus tumors of the kidney (n = 9) to identify features helpful in their separation, including immunohistochemistry for smooth muscle actin (SMA), CD34, collagen IV, CD117, GATA3, synaptophysin, and renin. "
5.	NeodymiumIBA 08/01/2013 - "We report a case of a 34-year-old man with a congenital plaque-like glomangioma on his left arm and forearm treated successfully with sequential pulsed-dye neodymium yttrium aluminum garnet laser. " 08/01/2013 - "Congenital plaque-like glomangioma treated successfully with dual wavelength pulsed-dye and neodymium:yttrium-aluminum-garnet laser."
6.	Coloring Agents (Dyes)IBA 08/01/2013 - "We report a case of a 34-year-old man with a congenital plaque-like glomangioma on his left arm and forearm treated successfully with sequential pulsed-dye neodymium yttrium aluminum garnet laser. " 08/01/2013 - "Congenital plaque-like glomangioma treated successfully with dual wavelength pulsed-dye and neodymium:yttrium-aluminum-garnet laser."
7.	yttrium-aluminum-garnetIBA 08/01/2013 - "We report a case of a 34-year-old man with a congenital plaque-like glomangioma on his left arm and forearm treated successfully with sequential pulsed-dye neodymium yttrium aluminum garnet laser. " 08/01/2013 - "Congenital plaque-like glomangioma treated successfully with dual wavelength pulsed-dye and neodymium:yttrium-aluminum-garnet laser."
8.	DesminIBA 07/01/1997 - "In half of six cases, the glomus tumor cells weakly expressed desmin. " 02/01/1987 - "Desmin immunoreactivity in glomus tumors." 12/01/1997 - "Epithelioid cells in human toes, finger tips, and glomus tumors did not express desmin, but it was present in rabbit ear. " 07/01/2011 - "Local excisions of all tumors were performed, and glomangiomas were diagnosed based on typical microscopic features as well as immunohistochemical findings, that is, positive immunoexpression for actin but negative for desmin, CD31, and CD34. " 02/01/2008 - "Strong immunoreactivity with antibodies to smooth muscle actin or desmin usually predicted a leiomyoma at follow-up aside from a single glomus tumor and a case with apparent nonneoplastic smooth muscle contaminant. "
9.	Collagen Type IV (Type IV Collagen)IBA 01/01/2011 - "The immunohistochemistry panel was positive for smooth muscle actin and type IV collagen, with low rate of mitosis studied by Ki-67 which allowed the final diagnosis of a gastric glomus tumor. " 01/01/2019 - "Postoperatively, immunohistochemistry confirmed the diagnosis of glomus tumor: alpha-smooth muscle actin (α-SMA) positive in the cytoplasm of malignant cells, type IV collagen positive in the basement membrane, cluster of differentiation 34 (CD34) negative in the malignant cells, CD34 positive in endothelial cells, Ki67 positive in the 1-2% of the cancer cells nuclei. " 11/01/2022 - "A previous fine needle aspiration biopsy had suggested a glomus tumor, and immunohistochemical analysis showed positive staining for smooth muscle actin, H-caldesmon, muscle-specific actin and collagen type IV. The MRI revealed a well-defined nodular lesion measuring 38x28x33 mm. The patient underwent surgery with no complications. " 05/01/2002 - "Immunohistochemical studies performed on cell block showed that the tumor cells were negative for CD34, CD117, chromogranin, synaptophysin, desmin and AE1/AE3 and were strongly positive for SMA, HHF-35 and collagen type IV. Glomus tumor was diagnosed and later confirmed by histology. " 10/01/1995 - "We immunostained 60 angioproliferative lesions (angiosarcoma, sclerosing hemangioma of skin, pyogenic granuloma, capillary hemangioma, lymphangioma, glomangioma and granulation tissue) and 23 cases of Kaposi's sarcoma (KS) for the major macromolecular components laminin, collagen type IV, fibronectin and heparan sulfate proteoglycan (HSPG). "
10.	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 02/01/2023 - "Small studies report glomus tumors with mutations in glomulin (GLMN), NF1, BRAF, NOTCH, PDGFRB, KRAS, and SMARCB1. " 01/01/2020 - "Despite their morphologic overlap, recent data suggest a dichotomy in their genetic signatures, including recurrent NOTCH gene fusions in glomus tumors and PDGFRB mutations in myofibromas and myopericytomas. " 01/01/2023 - "PDGFRB and NOTCH3 Mutations are Detectable in a Wider Range of Pericytic Tumors, Including Myopericytomas, Angioleiomyomas, Glomus Tumors, and Their Combined Tumors." 11/01/2021 - "In fact, glomus tumor involves frequent MIR143-NOTCH gene fusion whereas others pericytic tumor (myopericytoma and myofibroma) involve mutations of PDGFRB gene. " 01/01/2023 - "Therefore, we found PDGFRB and NOTCH3 mutations to be detectable in a much wider variety of pericytic tumors than previously reported and confirmed myopericytomas, myofibromas, angioleiomyomas, and glomus tumors as members harboring PDGFRB or NOTCH3 mutations. "

Therapies and Procedures

1.	Therapeutics 03/16/2022 - "The most effective therapy accepted for glomus tumors is complete surgical excision, and recurrence was rare after complete surgical excision." 01/01/2018 - "Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF." 01/01/2017 - "We present our experience in treating glomus tumors of the skull base with stereotactic radiosurgery as an upfront therapy. " 03/01/2004 - "Glomus tumors are rare, symptomatic (painful) lesions, with dimensions ranging 3-10 mm and usually subungual location, which need radical resection as a therapy. " 01/01/1999 - "An alternative and effective therapy for multiple glomangioma is proposed. "
2.	Radiotherapy 09/15/2009 - "It is suggested that radiotherapy is a good treatment modality in patients with glomus tumor, and metabolic imaging and treatment planning with positron emission tomography computed tomography is superior to other imaging modalities." 07/01/2023 - "A malignant glomus tumor in the nasal cavity responding to radiation therapy." 01/01/2012 - "Local control of glomus tumors of the head & neck by radiation therapy and surgery." 11/01/2005 - "Radiation therapy for glomus tumors of the temporal bone." 10/01/1995 - "Radiation therapy remains the treatment of choice for advanced glomus tumors."
3.	Operative Surgical Procedures 04/20/1978 - "Surgical procedures to remove glomus tumors of the pyramid could be improved by new anatomical and surgical experiences. " 06/01/2019 - "In this report, we present the diagnostic process and surgical procedure in this case and review the literature of glomus tumors with spine involvement. " 07/01/2011 - "On the basis of our experience, conservative surgical procedure is sufficient for penile glomus tumors. " 05/01/2009 - "Twenty-three patients diagnosed with subungual glomus tumor underwent surgical procedure using a dorsal transungual approach. " 03/01/1981 - "This is of paramount importance because the glomus tumor is essentially benign and does not warrant a radical surgical procedure. "
4.	Lasers (Laser) 09/01/1986 - "Laser treatment of hereditary multiple glomus tumors." 12/01/1978 - "Laser treatment of multiple progressive glomangiomas." 08/01/1981 - "Laser treatment of multiple glomangiomas: progress report 13 years after treatment." 03/01/1986 - "Advances in microsurgical techniques, with the use of the laser and the ultrasonic suction aspirator, have paved the way for even more aggressive surgical approaches to large skull-base lesions, such as glomus tumors, adenocarcinomas of the temporal bone, and cranial nerve neuromas. " 09/15/2009 - "In 12 NF1-associated glomus tumors, we used cell culture and laser capture microdissection to isolate DNA. "
5.	Retreatment 08/01/1994 - "Of the 4 tumors embolized but not operated on (3 metastases and 1 glomus tumor), 2 metastases needed retreatment after 6 and 8 months of remission, respectively. "