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Glipizide (Glucotrol)

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.

Also Known As:

Glucotrol; Alphapharm Brand of Glipizide; Glibenese Brand of Glipizide; Glupitel; K-4024; Kenfarma Brand of Glipizide; Lacer Brand of Glipizide; Lilly Brand of Glipizide; Melizide; Mindiab; Minidiab; Minodiab; Ozidia; Pfizer Brand 1 of Glipizide; Pfizer Brand 2 of Glipizide; Glipizide Kenfarma Brand; K 4024; K4024; Glidiazinamide; Glydiazinamide; Glypidizine; Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl-

Networked: 250 relevant articles (28 outcomes, 54 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Sulfur Compounds: 135
  - Sulfones: 136
    - Sulfonylurea Compounds: 29
      - Glipizide: 250
        metaglip

Experts

1.	Goldstein, Barry J: 5 articles (05/2013 - 03/2003)
2.	Kaufman, Keith D: 4 articles (05/2013 - 07/2011)
3.	Del Prato, S: 3 articles (06/2015 - 11/2014)
4.	Nauck, M: 3 articles (06/2015 - 04/2010)
5.	Rohwedder, K: 3 articles (06/2015 - 04/2013)
6.	Hong, Jie: 3 articles (10/2014 - 05/2013)
7.	Ning, Guang: 3 articles (10/2014 - 05/2013)
8.	Zhang, Yifei: 3 articles (10/2014 - 05/2013)
9.	Lai, Shenghan: 3 articles (10/2014 - 05/2013)
10.	Golm, Gregory T: 3 articles (05/2013 - 07/2011)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 09/01/2000 - "Quality of life was improved compared with baseline after 12 weeks' treatment with glipizide GITS 5 to 20 mg/day plus diet in a US double-blind, placebo-controlled trial in 569 patients with type 2 diabetes mellitus. " 12/01/1994 - "Comparative efficacy of a once-daily controlled-release formulation of glipizide and immediate-release glipizide in patients with NIDDM." 03/15/2015 - "In this study, 148 patients with type 2 diabetes mellitus (T2DM) were assigned randomly to receive either glipizide alone or glipizide plus Aralia root bark extract (ARBE) for 8 weeks to test the effects of ARBE plus glipizide therapy on glycemic control and lipid profiles in these patients. " 09/01/2006 - "The aim of this study was to compare the efficacy and tolerability of a sustained-release glipizide (GSR) formulation with those of immediate-release glipizide (GIR) in Chinese patients with type 2 diabetes mellitus. " 09/01/2006 - "Sustained-release versus immediate-release glipizide for treatment of type 2 diabetes mellitus in chinese patients: A randomized, double-blind, double-dummy, parallel-group, 12-week clinical study."
2.	Hyperglycemia 04/01/1995 - "During the course of the treatment and follow-up, hyperglycemia occurred in 6 of 10 subjects in the no treatment group, 6 of 10 in the placebo group, and 2 of 10 in the glipizide treatment group. " 10/01/2005 - "However, despite a salient effect of glipizide on the hyperglycemia of the mice, there was no effect on the time to occlusive thrombus formation (13.2 +/- 0.9 min, n = 4) compared with placebo-treated mice. " 07/01/1995 - "The effect of hyperglycemia on glipizide absorption in NIDDM patients." 01/01/1994 - "A standard dose of the oral sulfonylurea glipizide (200 micrograms/100 g), administered 15 min before a 1-h restraint stress to intact or 80% pancreatectomized rats, produced total suppression of the stress-induced hyperglycemia-hypoinsulinemia, an effect followed by a significant post-stress hypoglycemia of 1 h duration. " 03/01/2000 - "Glipizide and glyburide are effective in controlling hyperglycemia with similar doses in DM2. "
3.	Hypoglycemia (Reactive Hypoglycemia) 06/01/1998 - "This is the first report to describe the delayed onset of hypoglycemia in a child after ingestion of one tablet of glipizide. " 10/01/1980 - "The study of the kinetics of hypoglycemia induced by glipizide (second generation hypoglycemic sulfonamide) was carried out on the normal conscious dog. " 01/01/2014 - "In contrast to glipizide monotherapy, DPP-4 inhibitors showed no difference in HbA1c lowering effect (-0.08%, 95% CI -0.40 to 0.25) but had a lower incidence of hypoglycemia (RR 0.40, 95%CI 0.23 to 0.69). " 06/14/2012 - "As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice. " 11/01/2011 - "Patients administering sustained-release glipizide had less hypoglycemia (Peto odds ratio 0.21, 95% CI 0.08 to 0.52) and lower missed dosing (Peto odds ratio 11. "
4.	Weight Loss (Weight Reduction) 04/01/1985 - "Hypocaloric liquid formula diets were given for one month to 20 moderately obese patients with non-insulin-dependent diabetes mellitus divided into two equal groups; group 1 was treated with weight loss alone; group 2 received glipizide in addition to the hypocaloric diet. " 04/01/2013 - "Weight loss was observed with saxagliptin (-1.5 kg) vs. weight gain with glipizide (+1.3 kg; between-group difference, -2.8 kg, 95% CI, -3.32 kg to -2.20 kg). " 04/01/2010 - "Sitagliptin was generally well tolerated with a lower risk of hypoglycaemia and weight loss compared with weight gain observed with glipizide." 04/01/2010 - "Relative to baseline, sitagliptin was associated with weight loss (-1.6 kg) compared with weight gain (+0.7 kg) with glipizide. " 03/01/2007 - "Sitagliptin was generally well tolerated, with a lower risk of hypoglycaemia relative to glipizide and with weight loss compared with weight gain with glipizide."
5.	Diabetes Mellitus 11/30/1983 - "Our observations show that glipizide therapy is effective in certain patients with noninsulin-dependent diabetes mellitus over a prolonged time period. " 09/13/2006 - "Glipizide matrix transdermal systems for diabetes mellitus: preparation, in vitro and preclinical studies." 03/01/2006 - "Glipizide is a second-generation sulfonylurea commonly used to treat patients with noninsulin-dependent diabetes mellitus. " 06/01/2002 - "Pharmacokinetics and pharmacodynamics of extended-release glipizide GITS compared with immediate-release glipizide in patients with type II diabetes mellitus." 03/15/1997 - "Intensive 50-week evaluation of glipizide administration in 50 cats with previously untreated diabetes mellitus."

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Glyburide (Glibenclamide)
4.	Metformin (Glucophage)
5.	C-Peptide
6.	Lipoproteins (Lipoprotein)
7.	Chlorpropamide
8.	glimepiride (Amarel)
9.	2- (3- (4- ethoxybenzyl)- 4- chlorophenyl)- 6- hydroxymethyltetrahydro- 2H- pyran- 3,4,5- triol
10.	sitagliptin (Januvia)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Diet Therapy (Therapy, Diet)
3.	Injections
4.	Drug-Eluting Stents
5.	Transplants (Transplant)