Gliosis

01/01/2000 - "Young PDAPP transgenic mice were immunized with A beta 1-42, which essentially prevented amyloid deposition; astrocytosis was dramatically reduced and there was reduction in A beta-induced inflammatory response as well. "
09/01/2015 - "Amyloid-β induced astrocytosis and astrocyte death: Implication of FoxO3a-Bim-caspase3 death signaling."
06/01/2015 - "In mechanistic support in vivo, AD mouse model (APP (amyloid precursor protein)/PS1) brains contained increased SSH1/Cofilin and decreased SSH1/14-3-3 complexes, indicative of SSH1-Cofilin activation via release of SSH1 from 14-3-3. Finally, genetic reduction in Cofilin rescued APP/Aβ-induced synaptic protein loss and gliosis in vivo as well as deficits in long-term potentiation (LTP) and contextual memory in APP/PS1 mice. "
02/05/2015 - "In addition, they showed accelerated amyloid deposition, tau phosphorylation, and gliosis. "
11/01/2014 - "The lack of correlation between astrocytosis and CSF tau levels, and a positive correlation between astrocytosis and fibrillar amyloid deposition in clinical demented AD together indicate that parahippocampal astrocytosis might have some causality within the amyloid pathology."

04/01/2008 - "Minocycline reduced microglial activation and improved RGC axonal transport and integrity, yet it had no effect on the characteristic age-related ocular changes that lead to chronically elevated pressure and did not alter Müller or astrocyte gliosis. "
01/01/2013 - "Minocycline was absorbed without significant rumen biotransformation to maintain pharmacological concentrations of 1 μM in plasma and 400 nM in cerebrospinal fluid, but these did not result in inhibition of microglial activation or astrocytosis and did not change the neuronal loss or clinical course of the disease. "
11/01/2010 - "To determine whether this gliosis plays a role in decreasing anxiety, IL15Rα knockout mice were treated with minocycline, but this did not cause a change in open field performance. "
01/01/2010 - "Immunohistochemical analysis revealed that minocycline treatment resulted in fewer activated astrocytes in several cortical regions of htau mice, but did not affect astrocytosis in the hippocampus. "
04/01/2008 - "They quantified RGC numbers and characterized microglia activation, gliosis, and both axonal integrity and retrograde tracer transport by RGCs in mice systemically treated with minocycline or vehicle only. "

02/03/2003 - "We also examined the protective effects of melatonin against gliosis. "
06/01/2012 - "Melatonin also reduced reactive gliosis. "
10/01/2003 - "These results suggest that diabetes causes increased glial reactivity possibly due to elevated oxidative stress, and administration of melatonin represents an achievable adjunct therapy for preventing gliosis."
01/01/2006 - "Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats."
07/01/2005 - "Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats."

01/01/2015 - "MMF treatment significantly increased the expression of Nrf2-regulated antioxidative genes, suppressed inflammatory gene expression, reduced Müller cell gliosis, decreased neuronal cell loss in the GCL, and improved retinal function measured by electroretinogram (ERG) after retinal I/R injury in wild-type mice. "
04/01/2012 - "Epiretinal gliosis is known to occur with retinal tacks, but seems of no major concern to the integrity of the study eyes. "
05/01/2011 - "Massive retinal gliosis: an unusual case with immunohistochemical study."
08/28/2008 - "The purpose of the present study was to determine the content of protective factors in rat retinal progenitor cells and analyze the influence of the identified factors on the survival of photoreceptor cells and retinal gliosis. "
02/10/1998 - "The present study examines the distribution of this protein in the normal rat retina and its role in reactive gliosis occurring after retinal injury. "

01/01/2004 - "Although fyn expression in the brain has been allegedly limited to neurons and oligodendrocytes, we provide in this study the first evidence that fyn mRNA is highly expressed in the astrocytes involved in reactive gliosis. "
03/01/1991 - "The results of this study indicated that increased accumulation of GFAP mRNA was significant component of reactive gliosis and that the mechanisms responsible for the induction of GFAP were dissociated from those that regulate GS expression."
01/01/2015 - "Cln1(R151X) mice showed a significant decrease in Cln1 mRNA level and PPT1 enzyme activity, accumulation of autofluorescent storage material, astrocytosis and microglial activation in the brain. "
01/01/2014 - "Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain."
12/29/2009 - "These behavioral impairments were accompanied by robust reactive gliosis and elevated mRNA expression of inflammatory genes in the hippocampus. "

12/01/2012 - "Moreover, such online mapping can be helpful when removing the pericavernomatous gliosis while preserving functional structures, which can persist within the hemosiderin rim. "
09/01/2005 - "Brain MRI hyperintense (gliosis) or hypointense (hemosiderin) areas or both were assessed in the images of 135 adult TBI inpatients who completed a 2-year clinical, EEG, and MRI study protocol. "
10/01/1998 - "Biopsy samples and autopsy histopathological studies showed inflammatory cells, hemosiderin-laden macrophages, and astrocytosis. "
06/01/2015 - "Additionally, focal gliosis was observed in 6 animals and a single focus of hemosiderin deposition (coincident with focal gliosis and mononuclear cell infiltrate) was noted in 1 animal. "
01/01/2015 - "Autopsy findings included diffuse rarefaction of white matter with scattered microinfarcts, subpial gliosis, as well as perivascular lymphocytic aggregates and hemosiderin deposition in the sections from the posterior cerebrum. "

05/15/2007 - "In this study, neonatal transgenic mice at postnatal day (PD) 4 expressing GFP (green fluorescent protein) under the control of a widely used 2.2-kb human GFAP promoter in the brain are treated with two model neurotoxicants, 1-methyl-4(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH(3)-MPTP), and kainic acid (KA), respectively, to induce gliosis. "
12/13/2002 - "In the present study, the expression pattern of PTEN in the process of reactive gliosis was immunohistochemically examined in intracerebroventricular (i.c.v.) injected kainic acid mouse hippocampus. "
12/26/2014 - "However, we did observe local reorganization of α2δ-1 immunostaining in the hippocampus only in the kainic acid model, where it was associated with areas of neuronal cell loss, as indicated by absence of NeuN immunostaining, dendritic loss, as identified by areas where microtubule-associated protein-2 immunostaining was missing, and reactive gliosis, determined by regions of strong OX42 staining. "
01/01/2013 - "We found that kainic acid not only induced neurodegeneration but also arouse several caspase 3-mediated molecular and cellular changes including dendritic plasticity, neurogenesis, and gliosis. "
01/01/2011 - "Kainic acid was injected into the vitreous humor of C57BL/6 mice to induce reactive gliosis and death of RGCs. "

01/01/2011 - "In naive animals, endogenous levels of both Meteorin and CNTF were increased in glial cells in response to QA lesion indicating that Meteorin may exert its protective effects as part of the reactive gliosis cascade in the injured brain. "
04/01/1998 - "Since our studies in vivo have shown that CNTF induces other key aspects of gliosis (S. "
10/01/1996 - "The purpose of the present study was to establish whether CNTF induces other aspects of gliosis. "
01/01/2011 - "CNTF also appears to function as an inducer of gliosis in the retina."
01/30/2004 - "These results indicate that intrathecal infusion of exogenous CNTF following SCI may significantly reduce tissue damage and protect the rubrospinal descending tracks and enhances functional recovery, and may also induce more gliosis."

01/01/2010 - "Microscopically, spongiform changes, lipofuscin storage, corpora amylacea, gliosis and satellitosis were common, together with axonal and neuronal swellings. "
07/14/2009 - "Histological analysis of aged Pi4k2a(GT/GT) animals revealed lipofuscin-like deposition and gliosis in the cerebellum, and loss of Purkinje cells. "
03/01/2002 - "In contrast to lipofuscin accumulation and increased gliosis, the loss of perineuronal nets and the reduction of non-phosphorylated neurofilament H were in part reduced or prevented by housing the animals under enriched environmental conditions between 33 and 36 months of age. "
03/01/2002 - "With progressing age (12-36 months), a strong increase of lipofuscin and gliosis occurred in functionally characterized cortical areas, whereas a concomitant, area-specific loss of perineuronal nets was found in the cortical somatosensory representation of the hindlimbs. "
03/01/2002 - "Enriched environmental conditions reverse age-dependent gliosis and losses of neurofilaments and extracellular matrix components but do not alter lipofuscin accumulation in the hindlimb area of the aging rat brain."

01/01/1997 - "Without any additional studies involving noncultured cells the hypothesis for an ATP mediated induction of reactive gliosis lacks credibility."
05/01/2009 - "Mechanically induced reactive gliosis causes ATP-mediated alterations in astrocyte stiffness."
01/01/2003 - "The results indicate that increased responsiveness to extracellular ATP may be a more general feature of Müller cell gliosis, and is also observed in retinopathies besides PVR."
06/01/2001 - "We have tested the hypothesis that ATP may act as a trigger of reactive gliosis in an in vitro model (rat brain primary astrocytes) where reactive astrogliosis can be quantified as elongation of astrocytic processes. "
08/01/1994 - "The evidence suggests that extracellular ATP may be an important factor in regulating the extent of gliosis and, as such, may be involved in mechanisms of neural injury and repair."

03/01/2008 - "GFAP(-/-)Vim(-/-) mice exhibit attenuated posttraumatic reactive gliosis, improved integration of neural grafts, and posttraumatic regeneration. "
10/01/2015 - "Lipocalin-2 (Lcn-2) was identified as a potential new indicator of graft-induced reactive gliosis. "
01/01/2012 - "Unexpected outgrowth of the graft into the amygdala was accompanied by skewed distribution of LBs and gliosis, more abundant in the graft within the amygdala. "
10/25/2011 - "Graft-derived SOD1(G93A) astrocytes induced host MN ubiquitination and death, forelimb motor and respiratory dysfunction, reactive astrocytosis, and reduced GLT-1 transporter expression in WT animals. "
10/01/2006 - "Our goal was to determine the impact of advanced striatal damage and gliosis on the graft viability and host-graft integration. "

07/01/2015 - "Our data suggest that transplantation of encapsulated CPECs resulted in a significant decrease in apoptosis, reduced migration microglia, diminished gliosis, increased neurogenesis, and improved long-term memory as well as upregulated antioxidant activity. "
01/01/2016 - "Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina."
10/01/2015 - "Inhibition of stem cell-induced reactive gliosis is critical for successful transplantation-based strategies for neuroprotection, replacement, and regeneration of the optic nerve."
06/01/2014 - "In addition, MSC transplantation mitigated the brain damages that ensue after IVH and PHH, including reactive gliosis, cell death, delayed myelination, and impaired behavioral functions. "
01/01/2014 - "These results demonstrate that intravenous transplantation of hUCMSCs at an early stage after HIE can improve the behavior of hypoxic-ischemic rats and decrease gliosis. "

06/01/2004 - "Since activated glia may contribute to motor neuron degeneration, we tested whether inhibition of gliosis using low-dose chemotherapy is beneficial in this mouse model. "

06/01/2014 - "We have used cortical injury produced by intracranial electrodes (ICEs) to study the time-course and localization of gliosis and gliogenesis in surgically resected human brain tissue. "
07/15/2010 - "Technically, this study shows that a fetal neuron-glia culture system is well suited for characterizing the impact of electrode coatings designed to mitigate implant-associated gliosis, and for screening the effect of multiple soluble factors that promote and/or inhibit implant-associated gliosis. "
07/01/2014 - "The following histological changes were identified: fibrous sheaths (5-25 μm thickness) surrounding the electrode (94%), fibrillary gliosis (73%), reactive astrocytes (78%), multinucleated giant cells (75%), mononuclear leukocytes (92%), and macrophages (91%). "
04/01/2014 - "Around CNS implants, glial cells are activated, undergo gliosis and ultimately encapsulate the electrodes. "
01/01/2011 - "Brain tissue inflammatory responses, including neuronal loss and gliosis at the neural electrode/tissue interface, limit the recording stability and longevity of neural probes. "

09/01/2001 - "Histological analysis showed that Abeta 1-40 injections produced significant neuronal loss and gliosis. "
10/21/1996 - "These injections did not increase significantly the normal reactive gliosis induced by the lesion alone, but it accelerated some of the effects. "
07/20/1992 - "This effect depended on the injection parameters that were used; iontophoretic injections of short duration (less than or equal to 3 minutes) and low current strength (1.5 microA) caused the gliosis, higher injection parameters gave lesions. "
05/01/1987 - "Dense gliosis clearly demarcated the cannula tracks, but for most injections there were no surrounding regions of neuronal loss. "
05/01/2009 - "DCH deposits elicited no more gliosis, inflammation, or toxicity to neurons, myelin or axons than did injections of physiological saline. "