Necrotizing Ulcerative Gingivitis (Trench Mouth)

An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending from the interdental papillae along the gingival margins, PAIN; HEMORRHAGE, necrotic odor, and often a pseudomembrane. The condition may extend to the ORAL MUCOSA; TONGUE; PALATE; or PHARYNX. The etiology is somewhat unclear, but may involve a complex of FUSOBACTERIUM NUCLEATUM along with spirochetes BORRELIA or TREPONEMA.

Also Known As:

Networked: 89 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Lichen Planus (Lichen Ruber Planus)
2.	Pemphigus (Pemphigus Vulgaris)
3.	Hyperpigmentation
4.	Periodontitis
5.	Periodontal Diseases (Periodontal Disease)

Experts

1.	Solomon, L W: 4 articles (02/2012 - 09/2007)
2.	Sinha, S: 2 articles (02/2012 - 03/2010)
3.	Solomon, Lynn W: 2 articles (06/2011 - 12/2003)
4.	Kumar, V: 2 articles (03/2010 - 09/2007)
5.	Volchansky, Alf: 2 articles (01/2009 - 01/2009)
6.	Cleaton-Jones, Peter: 2 articles (01/2009 - 01/2009)
7.	Parodi, Aurora: 2 articles (09/2008 - 06/2007)
8.	Cozzani, Emanuele: 2 articles (09/2008 - 06/2007)
9.	Parodi, A: 2 articles (03/2004 - 09/2000)
10.	Cacciapuoti, M: 2 articles (03/2004 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrotizing Ulcerative Gingivitis:

1.	Immunoglobulin G (IgG)IBA 12/01/1967 - "IgG cryoglobulinaemia Case report and immunological studies of a patient with recurrent ulcerative stomatitis and high content of cold precipitable immunoglobulin in serum." 01/01/2000 - "Direct immunofluorescence revealed a speckled pattern of IgG deposits in the basal one-third of the epithelium, while indirect immunofluorescence confirmed the presence of stratified epithelium-specific antinuclear antigen (SES-ANA), both pathognomonic for chronic ulcerative stomatitis. " 03/01/1993 - "Serum IgG and IgM levels to bacterial antigens in necrotizing ulcerative gingivitis." 12/01/1999 - "Pathogen-related oral spirochetes were identified in dental plaque using monoclonal antibodies to putative Treponema pallidum-specific proteins, and serum from subjects with necrotizing ulcerative gingivitis contained immunoglobulin G to molecules thought to be restricted to T. "
2.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 06/01/1965 - "STUDIES OF VITAMIN-C IN ULCERATIVE STOMATITIS." 01/01/1947 - "Trench mouth (Vincent's infection) scurvy and vitamin C."
3.	Immunoglobulins (Immunoglobulin)IBA 12/01/1967 - "IgG cryoglobulinaemia Case report and immunological studies of a patient with recurrent ulcerative stomatitis and high content of cold precipitable immunoglobulin in serum."
4.	Penicillins (Penicillin)FDA Link 01/01/1951 - "[Treatment of ulcerative stomatitis with penicillin candy]." 01/01/1950 - "[Treatment of acute forms of ulcerative stomatitis with penicillin]." 11/01/1948 - "Penicillin in the treatment of Vincent's infection; a survey." 05/01/1947 - "Penicillin in the treatment of Vincent's infection." 04/01/1947 - "Penicillin in the treatment of Vincent's infection."
5.	cupric sulfide (CuS)IBA 04/01/2011 - "Chronic ulcerative stomatitis (CUS) is a mucocutaneous disorder which is characterised by persistent oral mucosal ulceration. " 03/01/2010 - "To develop a novel test for chronic ulcerative stomatitis (CUS), a chronic immunologically mediated condition that produces oral ulcerations. " 07/01/2008 - "Chronic ulcerative stomatitis (CUS) is a recently described condition with specific immunopathologic findings. " 09/01/2007 - "Chronic ulcerative stomatitis (CUS) is a recently described mucocutaneous condition in which patients experience chronic, painful, ulcerative lesions of the oral mucosa. " 08/01/2007 - "Chronic ulcerative stomatitis (CUS) is a recently described mucocutaneous disease characterized by involvement of mucosal surfaces and skin. "
6.	Antinuclear AntibodiesIBA 04/01/1996 - "Another case is reported herein and the subject of chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibodies (SES-ANA) is reviewed. " 04/01/1996 - "Chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibodies." 05/01/1992 - "Chronic ulcerative stomatitis associated with stratified epithelial specific antinuclear antibodies. " 05/01/1991 - "Ten cases of chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibody." 02/01/1990 - "Both in vivo binding to the oral mucosa and skin of a stratified epithelium-specific antinuclear antibody and high titers of these antibodies in serum are markers of this disease, which we refer to as chronic ulcerative stomatitis associated with stratified epithelium-specific antinuclear antibody."
7.	AntibodiesIBA 03/01/2010 - "ELISA test for p63 antibodies in chronic ulcerative stomatitis." 09/01/2000 - "Chronic ulcerative stomatitis: antibodies reacting with the 70-kDa molecule react with epithelial nuclei." 09/01/2008 - "Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planus." 06/01/2007 - "Antibodies to stratified epithelia characterize chronic ulcerative stomatitis, an entity that very closely resembles erosive lichen planus both clinically and histologically. " 02/01/1990 - "Both in vivo binding to the oral mucosa and skin of a stratified epithelium-specific antinuclear antibody and high titers of these antibodies in serum are markers of this disease, which we refer to as chronic ulcerative stomatitis associated with stratified epithelium-specific antinuclear antibody."
8.	AntigensIBA 03/01/2004 - "The antibody to the 70-kd antigen in chronic ulcerative stomatitis and lichen planus." 01/01/2000 - "Direct immunofluorescence revealed a speckled pattern of IgG deposits in the basal one-third of the epithelium, while indirect immunofluorescence confirmed the presence of stratified epithelium-specific antinuclear antigen (SES-ANA), both pathognomonic for chronic ulcerative stomatitis. " 09/01/2008 - "We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies. " 09/01/2008 - "Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa." 06/01/2007 - "Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus."
9.	Biological Markers (Surrogate Marker)IBA 06/01/1998 - "A molecule of about 70 kd is the immunologic marker of chronic ulcerative stomatitis." 02/01/1990 - "Chronic ulcerative stomatitis associated with a specific immunologic marker." 04/01/1996 - "In 1990 a new disease-associated antinuclear antibody was first recognized as a specific immunologic marker for a chronic form of ulcerative stomatitis (CUS). "
10.	Immunoglobulin A (IgA)IBA 10/01/2007 - "Approximately 48% of the specimens demonstrated positive DIF findings and consisted of pemphigus vulgaris, mucous membrane pemphigoid, lichen planus, linear immunoglobulin A disease, and chronic ulcerative stomatitis. " 09/01/1999 - "However, less common conditions such as pemphigus, dermatitis herpetiformis, linear IgA disease, erythema multiforme, chronic ulcerative stomatitis and other conditions may need to be excluded. " 12/01/1997 - "Most cases are related to lichen planus or pemphigoid, but it is also important to exclude pemphigus, dermatitis herpetiformis, linear IgA disease, chronic ulcerative stomatitis, and other conditions. "

Therapies and Procedures

1.	Oral Hygiene (Dental Hygiene) 11/01/1993 - "This study was designed to determine the association between oral hygiene status and necrotizing ulcerative gingivitis (NUG), as well as the severity of NUG in Nigerian children. " 11/01/1993 - "Oral hygiene status and necrotizing ulcerative gingivitis in Nigerian children."
2.	Drug Therapy (Chemotherapy) 10/01/1946 - "Drug therapy in Vincent's infection." 06/01/1980 - "Metronidazole is the drug of choice in the chemotherapy of necrotizing ulcerative gingivitis. "
3.	Crowns (Crown, Dental) 01/01/2009 - "A 27-year-old male presented with necrotizing ulcerative gingivitis with short clinical crowns suggestive of altered passive eruption. " 01/01/2009 - "A 27-year-old male presented with necrotizing ulcerative gingivitis with short clinical crowns suggestive of altered passive eruption. "
4.	Oral Administration 03/04/1990 - "[Successful treatment of recurrent ulcerative stomatitis, associated with cellular immune defect and hypozincaemia, by oral administration of zinc sulfate]." 11/01/1947 - "Oral administration of penicillin in the treatment of Vincent's infection."
5.	Highly Active Antiretroviral Therapy (HAART) 05/01/2012 - "The manifestations of HIV that were observed in children receiving HAART include dental caries (26%), periodontal diseases (23%), candidiasis (19%), hyperpigmentation (17%), ulcerative stomatitis (9%) and one case of mucocele. "