Gibberellins

A class of plant growth hormone isolated from cultures of GIBBERELLA FUJIKUROI, a fungus causing Bakanae disease in rice. There are many different members of the family as well as mixtures of multiple members; all are diterpenoid acids based on the gibberellane skeleton.

Also Known As:

Networked: 212 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yu, Su-May: 6 articles (10/2014 - 04/2002)
2.	Matsuoka, Makoto: 5 articles (09/2021 - 12/2005)
3.	Inomata, Naoko: 5 articles (08/2020 - 07/2017)
4.	Kojima, Mikiko: 5 articles (01/2018 - 04/2012)
5.	Sakakibara, Hitoshi: 5 articles (01/2018 - 04/2012)
6.	Foo, Eloise: 4 articles (12/2022 - 01/2018)
7.	Qing, Chen: 4 articles (12/2020 - 09/2009)
8.	Aihara, Michiko: 4 articles (08/2020 - 07/2017)
9.	Asami, Tadao: 4 articles (08/2018 - 06/2002)
10.	Kamiya, Yuji: 4 articles (04/2017 - 01/2008)

Related Diseases

1.	Dwarfism 07/01/2015 - "The Arabidopsis transgenics showed a significant reduction in endogenous gibberellins that might be responsible for the dwarfism, and the abnormal behaviour of pollen germination and seed set. " 01/01/2021 - "Gibberellin responsiveness study and quantitative real-time PCR showed a faulty gibberellin pathway and epistatic control between the genes such as OsKOL4 and OsBRD2 causing semi-dwarfism in a mutant. " 08/20/2018 - "In this study, we tested the effectiveness of gibberellin (GA) on restoring more tillering phenotype and dwarfism observed in both SL biosynthesis and signaling mutants. " 09/10/2023 - "Mutations in the Rht-B1a and Rht-D1a genes of wheat (Triticum aestivum; resulting in Rht-B1b and Rht-D1b alleles) cause gibberellin-insensitive dwarfism and are one of the most important elements of increased yield introduced during the 'Green Revolution'. " 09/01/2021 - "The regulatory role of gibberellin related genes DKGA2ox1 and MIR171f_3 in persimmon dwarfism."
2.	Dehydration (Water Stress) 09/01/2017 - "The semi-dwarf cultivar with Dw1 gene was less sensitive to gibberellins and its mechanisms of acclimation to water stress were mainly ABA-dependent. " 03/05/2020 - "The role of mucilage in water absorption/dehydration, the effects of after-ripening, gibberellin acid (GA3), cold stratification and seed coat scarification on germination, the role of mucilage in germination and seedling growth during drought, and the progress of mucilage production during seed development were investigated. " 03/31/2019 - "Under optimum water level, using of 4.5 ml L-1of zinc sulfate and under severe water stress conditions, using of 4.5 ml L-1 of zinc sulfate plus gibberellin are recommended for obtaining the maximum crop performance." 10/01/2016 - "Abscisic acid appeared to function in the water stress response induced by xylem structures and/or osmotic alterations in the compression sides, whereas gibberellins may control cell elongation and gravitropisms. " 09/10/2013 - "Among these 24 TFs, the unigene19721 encoding the DELLA protein which is a key negative regulator in gibberellins (GAs) signal pathway was probably markedly up-regulated under water stress for a increase of tag abundance in DS library, which is possibly responsible for the inhibition of the growth of drought-stressed ramie. "
3.	Type I Syndactyly 09/21/2023 - "Among them, six loci were co-localized with known genes such as semidwarf-1 (sd1) and Grain Number per Panicle1 (GNP1) involved in gibberellin biosynthesis. " 11/01/2020 - "The wild allele of SD1 is a dominant locus that can significantly promote rice internode length by regulating the expression levels of genes involved in gibberellin biosynthesis and signal transduction. " 01/01/2018 - "Here, we identify the gibberellin biosynthesis gene, SD1 (SEMIDWARF1), whose loss-of-function allele catapulted the rice Green Revolution, as being responsible for submergence-induced internode elongation. " 01/01/2017 - "Meanwhile, two QTLs were found for plant height, and a candidate gene showed 89% identity to the known rice gibberellin-synthesis gene sd1. " 04/01/2014 - "Mutants involved in GA biosynthetic and response pathways were hypersensitive to LT stress, including the semidwarf mutants sd1 and d35, the gain-of-function mutant slr1-d, and gibberellin insensitive dwarf1. "
4.	Cold Injury 01/01/2019 - "True tolerance involved improved protection of the cell membrane against cold injury at temperatures close to 0 °C and stimulation of light-induced processes (accumulation of anthocyanins, carotenoids, and chlorophyll, proper development of chloroplasts) at temperatures in the range of 10-14 °C, likely also related to the increased photosensitivity and mediated by gibberellin signaling."
5.	Neoplasms (Cancer) 10/08/2020 - "Not only was JRA-003 identified as the most potent synthetic gibberellin against cancer-derived cell lines, it displayed no cytotoxicity in cells derived from noncancerous sources (HEK 293T, HS 578BST, HS 888Lu, HS 895Sk, HUVEC). " 10/08/2020 - "Analogs of JRA-003 were synthesized and NF-κB-inhibiting gibberellins were found to be cytotoxic in cancer-derived cell lines (HS 578T, HCC 1599, RC-K8, Sud-HL4, CA 46, and NCIH 4466). " 09/15/2009 - "Synthesis of gibberellin derivatives with anti-tumor bioactivities." 06/01/1975 - "It is suggested that the natural loss of susceptibility to tumor induction in maturing pinto bean leaves is associated with a concomitant loss of endogenous gibberellins and/or a sensitivity to gibberellins." 01/01/2016 - "Gibberellin derivative GA-13315 sensitizes multidrug-resistant cancer cells by antagonizing ABCB1 while agonizes ABCC1."

Related Drugs and Biologics

1.	Abscisic Acid
2.	Cytokinins
3.	Salicylic Acid (2 Hydroxybenzoic Acid)
4.	indoleacetic acid (indole acetic acid)
5.	Carotenoids (Carotene)
6.	Oxidoreductases (Dehydrogenase)
7.	Chlorophyll
8.	Anthocyanins (Anthocyanin)
9.	Melatonin
10.	Indoleacetic Acids (Auxin)