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Hypertrophic Gastritis (Giant Hypertrophic Gastritis)

Subscribe to New Research on Hypertrophic Gastritis

GASTRITIS with HYPERTROPHY of the GASTRIC MUCOSA. It is characterized by giant gastric folds, diminished acid secretion, excessive MUCUS secretion, and HYPOPROTEINEMIA. Symptoms include VOMITING; DIARRHEA; and WEIGHT LOSS.

Also Known As:

Giant Hypertrophic Gastritis; Gastritis, Hypertrophic; Gastritis, Familial Giant Hypertrophic; Menetrier's Disease; Disease, Menetrier; Disease, Menetrier's; Gastritis, Giant Hypertrophic; Hypertrophic Gastritis, Giant; Menetriers Disease; Menetrier Disease

Networked: 67 relevant articles (4 outcomes, 2 trials/studies)

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Disease Context: Research Results

Digestive System Diseases: 46
- Gastrointestinal Diseases: 1735
  - Gastroenteritis: 2437
    - Gastritis: 5191
      - Hypertrophic Gastritis: 67
  - Stomach Diseases: 481
    - Gastritis: 5191
      - Hypertrophic Gastritis: 67

Related Diseases

1.	Hypertrophy
2.	Hypoproteinemia
3.	Polyps
4.	Neoplasms (Cancer)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Taylor, Kathryn: 2 articles (07/2003 - 03/2002)
2.	Dent, David M: 2 articles (07/2003 - 03/2002)
3.	Mall, Anwar S: 2 articles (07/2003 - 03/2002)
4.	Kahn, Delawir: 2 articles (07/2003 - 03/2002)
5.	Tonai, Shunsuke: 2 articles (01/2003 - 09/2002)
6.	Okabe, Susumu: 2 articles (01/2003 - 09/2002)
7.	Maeda, Kazuhiko: 2 articles (01/2003 - 09/2002)
8.	Rodríguez Gonzalez, Omaira: 1 article (09/2015)
9.	Génesis, Jara: 1 article (09/2015)
10.	Raquel, Ferrnandez: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertrophic Gastritis:

1.	cetuximab (Erbitux)FDA Link 11/25/2009 - "Efficacy of cetuximab in the treatment of Menetrier's disease."
2.	Gastric MucinsIBA 07/01/2003 - "Expression of gastric mucin in the stomachs of two patients with Menetrier's disease: an immunohistochemical study." 03/01/2002 - "Extraction, isolation, and SDS-PAGE analysis of purified gastric mucin in a patient with Menetrier's disease."
3.	BariumIBA 05/01/1999 - "Our prospective study consisted of 39 patients with gastric lesions (17 gastric carcinomas, nine gastric polyps, five gastric varices, five gastric submucosal tumors, one lymphoma, one case of Menetrier's disease, and one gastric erosion) detected by endoscopy and barium study. "
4.	Octreotide (Sandostatin)FDA LinkGeneric 06/07/2012 - "A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release." 07/01/2005 - "Menetrier's disease: an excellent response to octreotide. " 12/01/2004 - "Menetrier's disease treated with octreotide long-acting release."
5.	Staphylococcal Protein A (A, Protein)IBA 10/01/1979 - "Transient hypertrophic gastropathy in childhood: a protein-losing gastropathy distinct from Menetrier's disease." 01/01/2015 - "Menetrier's disease is a rare entity in children, characterized by a protein-losing gastroenteropathy with thickening of the gastric mucosa and generalized edema. " 08/01/1978 - "A patient with exocrine pancreatic insufficiency and hypoalbuminemic edema was shown also to have a protein-losing gastropathy secondary to giant hypertrophic gastritis (Ménétrier's disease). "
6.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 01/01/2009 - "Menetrier's disease is a rare hyperproliferative disorder of the stomach caused by an overexpression of tumour growth factor α, a ligand for the tyrokinase epidermal growth factor receptor, resulting in a selective expansion of surface mucous cells in the body and fundus of the stomach. " 10/01/2004 - "Members of the Reg family, RegIIIbeta and RegIIIgamma, were greatly elevated in mice with hypertrophic gastritis, whereas RegI and amphiregulin (an EGF receptor ligand) were more modestly and/or inconsistently induced. "
7.	Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA 07/01/1989 - "Pancreatic polypeptide and insulin-secreting tumor in a dog with duodenal ulcers and hypertrophic gastritis." 08/01/1984 - "Hamartomatous polyp in adult oxyntic mucosa, hyperplastic oxyntic mucosa in Menetrier's disease and atrophic oxyntic mucosa in a remnant stomach with cancer showed scattered glucagon-glicentin cells, but few or no cells containing bovine pancreatic polypeptide. "
8.	MucinsIBA 07/01/2003 - "All stomachs stained positively for MUC4, 5AC and 6 and showed no or little staining with MUC2 and 3. Thus, Menetrier's disease is characterized by an excess quantity of mucus secretion, but differs little from normal stomachs with regards to the types of mucin produced. " 03/01/2002 - "The fragmentation pattern of mucin in Menetrier's disease demonstrated less large polymeric mucin than the control. "
9.	IronIBA 02/01/1986 - "Menetrier's disease presenting with deep venous thrombosis, iron deficiency anaemia and early evolution to atrophic gastritis." 04/01/1985 - "Antral hypertrophic gastritis: a rare cause of iron deficiency."
10.	GastrinsIBA 03/01/1975 - "Menetrier's disease with normal serum gastrin." 01/01/2000 - "We report a case of pseudo-Zollinger-Ellison syndrome in a 17-year-old man presenting with gastrin levels exceeding 2000 pmol/l and BAO 24 mEq/hr. Histologically, apart from hypertrophic gastritis with the thickening of mucosal folds and diffuse G-cell hyperplasia, gastric mucosa was found to contain foci of pancreatic metaplasia."

Therapies and Procedures

1.	Gastrectomy 01/01/2014 - "Canine giant hypertrophic gastritis treated successfully with partial gastrectomy." 09/01/2015 - "Robot-assisted laparoscopic gastrectomy for Menetrier's disease." 12/01/2012 - "Partial gastrectomy was performed and histology was consistent with hypertrophic gastritis with typical features of Ménétrier's disease. " 10/01/1987 - "We suggest that in documented Menetrier's disease elective total gastrectomy should still be considered as a treatment of choice." 04/30/1978 - "[Total gastrectomy for Menetrier's disease and reconstruction of alimentary continuity, using the Moricca technic]."
2.	Gastroenterostomy 02/01/1979 - "Stomal polypoid hypertrophic gastritis: a polypoid gastric lesion at gastroenterostomy site." 02/01/1951 - "[Complication of a giant hypertrophic gastritis: late rapture of a gastroenterostomy]."
3.	Nutritional Support (Artificial Feeding) 02/01/1986 - "Although Menetrier disease in children has a benign and transient course, we found the use of home hyperalimentation significantly shortened the length of hospitalization and provided adequate nutritional support until the gastric lesions began to resolve."
4.	Home Parenteral Nutrition 02/01/1986 - "Home parenteral nutrition in a child with Menetrier disease."
5.	Thrombolytic Therapy 01/01/1978 - "Anti-fibrinolytic therapy of giant hypertrophic gastritis (Menetrier's disease)."