Atrophic Gastritis

GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.

Also Known As:

Networked: 1751 relevant articles (53 outcomes, 220 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Stomach Neoplasms (Stomach Cancer)
3.	Metaplasia
4.	Gastritis
5.	Neoplasms (Cancer)

Experts

1.	Yuan, Yuan: 29 articles (11/2020 - 03/2002)
2.	Sun, Li-Ping: 15 articles (12/2018 - 12/2002)
3.	Xu, Qian: 15 articles (12/2018 - 03/2013)
4.	Tsugane, Shoichiro: 12 articles (01/2022 - 12/2002)
5.	Annibale, Bruno: 12 articles (01/2021 - 07/2002)
6.	Lahner, Edith: 12 articles (01/2021 - 08/2009)
7.	Malfertheiner, Peter: 12 articles (01/2021 - 10/2005)
8.	Kim, Nayoung: 12 articles (01/2019 - 12/2006)
9.	Haruma, Ken: 11 articles (01/2022 - 09/2003)
10.	Hahm, Ki Baik: 11 articles (09/2021 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Atrophic Gastritis:

1.	AcidsIBA 09/01/1995 - "However rapid development of atrophic gastritis has been consistently observed in a number of studies during low acid output. " 01/01/2020 - "Ion transporter dysfunction results in disordered ion transport, mucosa barrier dysfunction, and acid/base disturbances, causing gastric acid-related diseases such as chronic atrophic gastritis (CAG) and GC. " 06/01/2015 - "Atrophic gastritis will finally end up in a permanently acid-free stomach in the most extreme cases. " 03/01/2014 - "Collectively, a careful administration of anti-acids to the elderly, especially those with atrophic gastritis, is necessary to avoid repression of the gastric barrier to bacteria." 11/01/2006 - "The acid-secreting mucosa in the fundus expanded in most cases with fundic atrophic gastritis after H pylori eradication, which could be responsible for the increase in acid secretion after the treatment. "
2.	Pepsinogen A (Pepsinogen)IBA 06/01/2022 - "This study aimed to initially assess the diagnostic value of the serum pepsinogen in diagnosis of moderate and severe atrophic gastritis for Vietnamese population. " 07/20/2017 - "The aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (AG) in health check-up populations in China. " 04/01/2013 - "The aim of this study is to verify the potential for pepsinogen I and II to detect atrophic gastritis (AG) in both high and low risk populations for GC. " 06/01/2009 - "This study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. " 03/01/1998 - "This study assesses the level of agreement between the degree of atrophic gastritis as assessed by endoscopic examination and by serum pepsinogen assays. "
3.	GastrinsIBA 01/01/2003 - "In all successfully eradicated patients with atrophic gastritis a significant increase in gastric acid secretion and decrease in serum gastrin were observed. " 01/01/2018 - "The aim of this study was to investigate the effects of long-term PPIs use on the gastrin levels in patients with atrophic gastritis and to determine factors affecting hypergastrinemia in long-term users of PPIs. " 01/01/1985 - "Prior to a study of the pathophysiological significance of chronic atrophic gastritis and hypergastrinemia, we evaluated a new radioimmunoassay kit for serum total gastrin (Diagnostic Products Corp.). " 05/01/2020 - "The clinical indication and guidelines for performing IHC for detecting Helicobacter pylori is discussed along with role of gastrin and neuroendocrine markers in the diagnosis of autoimmune metaplastic atrophic gastritis. " 06/01/2013 - "Mean serum gastrin was 1209.6±268.48 pg/mL in patients with autoimmune atrophic gastritis and 234.95±184.018 pg/mL in patients with chronic non-atrophic gastritis. "
4.	AntibodiesIBA 02/01/2001 - "In this study, CagA antibodies alone had the best combination of test characteristics for chronic atrophic gastritis screening. " 01/01/2021 - "Thyroid function, hematologic indices, and atrophic gastritis markers [parietal-cell antibodies (PCab), Helicobacter pylori antibodies (H. " 11/01/2020 - "Autoimmune atrophic gastritis (AAG) diagnosis is based on specific histological findings and anti-parietal cell antibodies (PCA) considered the serological hallmark of AAG, although a subgroup of AAG patients may be seronegative. " 10/01/2017 - "pylori antibodies serological assays appears to be a reliable tool for the diagnosis of atrophic gastritis. " 10/01/2017 - "pylori antibodies serological assays (panel test) is a non-invasive tool for the diagnosis of atrophic gastritis. "
5.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 08/01/1998 - "The high prevalence of mild cobalamin deficiency in healthy, free-living, older Dutch subjects could be explained by inadequate cobalamin intake or severe atrophic gastritis in only 28% of the study population. " 02/01/2023 - "The patient had atrophic gastritis, which could have impeded the absorption of vitamin B12 from food. " 03/01/2015 - "We propose an algorithm for the diagnostic approach considering the current performance and limitations of the available diagnostic tools for evaluation of cobalamin status and the presence of autoimmune chronic atrophic gastritis (CAG). " 09/01/2013 - "The main cause is vitamin B12 malabsorption resulting from a type B atrophic gastritis. " 07/01/2012 - "Biermer's disease is an autoimmune atrophic gastritis of the fundus predominantly responsible for a malabsorption of vitamin B12. "
6.	Huang QiIBA 11/01/2023 - "Huangqi Jianzhong Tang (HQJZ) is effective for treating chronic atrophic gastritis (CAG). " 08/26/2023 - "This study demonstrated that Huangqi Jianzhong decoction improved various factors in adults with chronic atrophic gastritis. " 08/26/2023 - "To evaluate the efficacy of Huangqi Jianzhong decoction in treating chronic atrophic gastritis. " 08/26/2023 - "We performed a comprehensive search for clinical trials investigating the use of Huangqi Jianzhong decoction in treating chronic atrophic gastritis published until January 2023. " 08/26/2023 - "Huangqi Jianzhong decoctions are widely used in China to treat chronic atrophic gastritis. "
7.	gastrin 17 (G 17)IBA 02/01/2020 - "To study gastrin-17 production, morpho-functional correlation was studies in 75 patients with multifocal atrophic gastritis. " 01/01/2022 - "pylori-positive patients had higher serum PGs/gastrin-17 (G-17) levels and lower PGR levels, regardless of OLGA/OLGIM stages I-II or III-IV. Furthermore, eight patients with atrophic gastritis who progressed to GC were previously in OLGA stages III-IV and OLGIM stages II-IV. The average duration of this process was 2.19±1.03 years. " 11/01/2020 - "Prevalence of atrophic gastritis in southwest China and predictive strength of serum gastrin-17: A cross-sectional study (SIGES)." 02/01/2020 - "In total, 2,847 people aged > 40 years old underwent serological noninvasive screening for atrophic gastritis by identifying postprandial gastrin-17 and pepsinogen-1 in the fasting state. " 05/01/2016 - "A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG).An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. "
8.	Methylnitronitrosoguanidine (MNNG)IBA 07/31/2023 - "Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats." 08/28/2022 - "Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats." 04/25/2021 - "目的：通过观察慢性萎缩性胃炎(chronic atrophic gastritis,CAG)大鼠胃黏膜细胞凋亡水平及核转录因子-κB(NF-κB)、B淋巴细胞瘤-2(Bcl-2)基因表达变化来探究针灸对CAG的治疗机制。方法：将健康雄性SD大鼠随机分为正常组、模型组、艾灸组、针刺组，每组12只。采用1-甲基-3-硝基-1-亚硝基胍(MNNG)联合多因素法(MNNG+乙醇灌胃+饥饱失常法)造模12周制备CAG大鼠模型。艾灸组予“足三里”“中脘”悬灸15 min，针刺组予 “足三里”“中脘”直刺15 min，均每日1次，连续治疗2周。HE染色法观察各组大鼠胃黏膜形态变化，TUNEL法测定并计算各组大鼠胃黏膜细胞凋亡指数，实时荧光定量PCR法检测各组大鼠胃黏膜组织NF-κB、Bcl-2的基因表达水平。结果：模型组大鼠肉眼下胃黏膜色白淡暗，皱襞低平且有显著出血点，光镜下黏膜固有层腺体萎缩，排列错乱且数量显著减少，炎性细胞浸润；艾灸组和针刺组胃黏膜形态均得到改善。与正常组比较，模型组胃黏膜细胞凋亡指数显著增加(P<0.01)；与模型组比较，艾灸组与针刺组胃黏膜细胞凋亡指数均显著降低(P<0.01)。与正常组比较，模型组胃黏膜组织NF-κB、Bcl-2 基因表达显著升高(P<0.01)；与模型组比较，艾灸组、针刺组胃黏膜组织NF-κB、Bcl-2 基因表达均显著降低(P<0.05，P<0.01)；与艾灸组比较，针刺组胃黏膜组织Bcl-2基因表达明显降低(P<0.01)。结论：传统针灸疗法可以下调CAG大鼠胃黏膜细胞凋亡指数，平衡胃黏膜细胞过度凋亡，降低NF-κB、Bcl-2基因表达，缓解大鼠胃黏膜炎性反应，保护胃黏膜组织，针灸调控胃黏膜细胞凋亡的机制可能与降低NF-κB、Bcl-2基因表达有关。." 02/01/2021 - "The statistical results found that modeling methods with a higher coincidence degree with the existing chronic atrophic gastritis animal models are disease and syndrome combination mode-ling, surgical modeling, multifactor comprehensive modeling and MNNG modeling. " 01/01/1997 - "We sequentially analyzed the markers of proliferation and differentiation of rat atrophic gastritis induced by MNNG. "
9.	Proton Pump InhibitorsIBA 06/01/2001 - "Most studies have now accepted that proton pump inhibitors indeed accelerate the onset of atrophic gastritis in H. " 07/01/1998 - "Two recent studies on the relation between treatment with proton pump inhibitors and atrophic gastritis have yielded apparently contradictory results. " 01/01/2022 - "The Impact of Proton Pump Inhibitors on the Development of Gastric Neoplastic Lesions in Patients With Autoimmune Atrophic Gastritis." 01/01/2021 - "The two groups were matched for age, sex, history of proton pump inhibitor use, and atrophic gastritis. " 04/01/2020 - "DIAGNOSTIC ACCURACY OF GASTROPANEL® FOR ATROPHIC GASTRITIS IN BRAZILIAN SUBJECTS AND THE EFFECT OF PROTON PUMP INHIBITORS."
10.	banxia xiexin decoctionIBA 01/01/2020 - "Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis." 12/01/2019 - "Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis." 10/16/2020 - "This study will provide reliable evidence for the clinical application of Banxia Xiexin decoction in the treatment of chronic atrophic gastritis. " 10/16/2020 - "Besides, Baidu Scholar and Google Scholar were manually searched, and all randomized controlled trials of Banxia xiexin decoction for the treatment of chronic atrophic gastritis were collected. " 10/16/2020 - "Therefore, this study aims to explore the clinical efficacy and safety of Banxia Xiexin decoction in the treatment of chronic atrophic gastritis by means of systematic evaluation. "

Therapies and Procedures

1.	Therapeutics 01/01/2018 - "Helicobacter pylori Eradication Therapy Ameliorates Latent Digestive Symptoms in Chronic Atrophic Gastritis." 01/01/2017 - "The efficacy of Jianpi Yiqi therapy for chronic atrophic gastritis: A systematic review and meta-analysis." 01/01/2018 - "This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis. " 11/07/2005 - "Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. " 02/02/2021 - "Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. "
2.	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/01/2023 - "As a classical traditional Chinese medicine (TCM), Xiaojianzhong Tang (XJZ) is effective in treating chronic atrophic gastritis (CAG). " 07/20/2023 - "Traditional Chinese medicine (TCM) Xiaojianzhong Tang (XJZ) has a favorable efficacy in the treatment of chronic atrophic gastritis (CAG). " 03/21/2023 - "Research on the experience of National Master of Traditional Chinese Medicine Professor Lu ZhiZheng in treating chronic atrophic gastritis based on data mining technology." 01/01/2023 - "There are currently no standard treatments for chronic atrophic gastritis and traditional Chinese medicine may be effective. " 12/01/2022 - "Shidan granule is an in-hospital traditional Chinese medicine prescription with obvious clinical effects in the treatment of chronic atrophic gastritis. "
3.	Moxibustion 01/01/2018 - "Acupuncture and moxibustion proved to be very effective in chronic atrophic gastritis (CAG). " 02/28/2022 - "Author Correction: Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)." 10/30/2017 - "Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)." 04/25/2021 - "To observe the effect of moxibustion and acupuncture on apoptosis in gastric mucosal cell and expression of NF-κB, Bcl-2 in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improvement of CAG. " 04/25/2021 - "[Effect of moxibustion and acupuncture on gastric mucosal cell apoptosis and expression of NF-κB, Bcl-2 in chronic atrophic gastritis rats]."
4.	Aftercare (After-Treatment) 01/01/2010 - "In chronic atrophic gastritis, the gastric juice levels of NO did not achieve normal values after treatment despite the onset of clinical remission which may be caused by a continuous gastric mucosal atrophic process." 06/15/1997 - "Among severe atrophic gastritis patients (n = 9), five improved into moderate atrophic gastritis after treatment and four experienced no improvement. " 10/16/2020 - "Western medicine has a certain effect on chronic atrophic gastritis, but there are many adverse reactions after long-term medication, and the disease is prone to relapse after treatment, which will affect the health and life of patients. " 04/18/1996 - "pylori had atrophic gastritis before treatment that persisted after treatment. " 09/16/2023 - "On day 7 after onset, gastroscopy revealed chronic non-atrophic gastritis and erosive duodenitis without purpuric rash, and no obvious resolution of the abdominal pain was found after treatment against infection and for protection of gastric mucosa. "
5.	Lasers (Laser) 04/01/2022 - "Background and study aims  Probe-based confocal laser endomicroscopy (pCLE) can provide high magnification to evaluate chronic atrophic gastritis (CAG), but the current pCLE criteria are qualitative and prone to variability. " 05/01/2015 - "The aim of this study was to compare chromoendoscopy (CE), narrow band imaging (NBI), and confocal laser endomicroscopy (CLE) in diagnosing atrophic gastritis. " 10/01/2005 - "This study sought to explore the effects of He-Ne laser irradiation on the gastric mucosa of experimental chronic atrophic gastritis (CAG) in rat. " 07/07/2005 - "To study the effects of He-Ne laser irradiation on experimental chronic atrophic gastritis (CAG) in rats. " 05/07/2023 - "Mucosal patterns (MPs) observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty, cracked, and mottled. "