Gangrene

01/01/1991 - "Digital gangrene in small cell lung cancer: response to aspirin treatment."
01/01/1991 - "A patient who had small cell lung cancer complicated by symmetrical peripheral gangrene, secondary to spontaneous platelet aggregation, improved dramatically after starting aspirin treatment."
01/01/2021 - "All endpoints were significantly improved compared with the aspirin group (p<0.01), and no rest pain or ulcer/gangrene recurred during follow-up. "
01/01/2015 - "If not treated with aspirin, ET and PV patients are at a high risk of major arterial thrombosis including stroke, myocardial infarction and digital gangrene."
08/01/2002 - "The patient was treated with aspirin and diclofenac, and improved slowly with complete resolution of gangrene and symptoms after 3 months. "

10/01/2009 - "Early and aggressive corticosteroid treatment prevented gangrene from progression and improved prognosis."
11/01/2022 - "• Corticosteroids alone with rapid tapering may be an appropriate option to consider in the initial management of digital gangrene in connective tissue disorders."
11/01/2022 - "Corticosteroids alone with rapid tapering may be an appropriate option to consider in the initial management of digital gangrene in CTD. "
06/01/1967 - "[Corticosteroids and the treatment of gangrene]."
05/01/2004 - "The digital gangrene gradually progressed and was unresponsive to corticosteroid therapy. "

01/01/2013 - "In our opinion, as more powerful agents, anticoagulants should be considered in severe cases of development of digital gangrenes. "
12/01/2000 - "Surgical: if DVT is diagnosed at an early stage, anticoagulant treatment may be accompanied by attempted surgical deobstruction, above all if DVT is localised at the popliteal and femoral confluents (greater risk of evolution towards severe "ischemic" forms potential cause of venous gangrene). "
05/01/1970 - "Gangrene of the female breast with anticoagulant therapy: report of two cases."
02/10/1964 - "[A RARE COMPLICATION OF ANTICOAGULANT THERAPY: HEMORRHAGIC GANGRENE OF THE BREAST. "
07/01/1963 - "BREAST HAEMORRHAGE AND GANGRENE DURING ANTICOAGULANT THERAPY."

01/01/2023 - "There was no improvement even after starting cyclophosphamide, and the gangrene further worsened. "
11/01/2016 - "Disease progressed to result in gangrene of hands and feet despite receiving intravenous cyclophosphamide. "
11/01/2023 - "Use of prostaglandin and cyclophosphamide for pediatric lupus with digital gangrene: Back to safety before hitting the axe!"
08/01/1998 - "A few months after starting a combined therapy with cyclophosphamide and corticosteroids the patient showed a partial remission with a residual toe gangrene. "
02/01/2023 - "Thirty-two (68.1%) gangrene patients received methylprednisolone pulse therapy and all of these patients were treated with cyclophosphamide. "

01/01/2018 - "Primary outcomes included combined VTE events (PE and recurrent DVT), gangrene, heparin complications, and death. "
08/01/2009 - "Thrombotic cutaneous gangrene is a rare complication of heparin-induced thrombocytopaenia after cardiac surgery. "
07/18/2007 - "Outcomes included PE, recurrent DVT, gangrene, heparin complications, and death. "
01/01/2001 - "Outcomes included PE, recurrent DVT, gangrene, heparin complications, and death. "
08/01/1990 - "Patients who presented with imminent gangrene were promptly operated upon, whereas those who had less severe ischaemia were treated initially with heparin only. "

01/01/2017 - "Here, we report a 54-year-old man who presented to the emergency department with acral and penile gangrene following prolonged use of warfarin."
01/01/2017 - "Concurrent Hand and Penile Gangrene following Prolonged Warfarin Use; a Case Report."
05/01/2014 - "The lesser known side-effect of warfarin: warfarin-induced venous limb gangrene."
11/01/2012 - "A lesser known adverse reaction to warfarin is warfarin-induced venous limb gangrene. "
11/01/2012 - "Warfarin-induced Venous Limb Gangrene."

02/01/1946 - "Postoperative bacterial synergistic gangrene cured with penicillin."
01/01/1995 - "A patient with right lower limb gangrene that developed after penicillin injection is presented. "
01/01/1995 - "Gangrene after penicillin injection (a case report)."
11/13/1981 - "Continuation of penicillin treatment led to occlusion of larger arteries with gangrene of the forefoot. "
02/01/1959 - "[A case of foot gangrene in an infant after penicillin treatment]."

10/01/1998 - "In patients with gangrene the difference in morbidity between the reference group (35%) and the PGE1 alpha-ciclodestrina group (27%) was even more evident (P < 0.025). "
10/01/1995 - "Atypical KD with peripheral gangrene appears to react favourably to treatment with PGE1, but needs careful monitoring to detect early signs of cardiac ischaemia."
01/01/1989 - "Influence of prostaglandin E1 on muscular tissue-PO2 in patients with diabetic gangrene."
01/01/1985 - "For the present time, intraarterial infusion of PGE1 is the treatment of choice for impending gangrene. "
10/01/1998 - "In rest pain and gangrene the infusion of PGE1 alpha-ciclodestrina in the late evening increased the average night flux (which tended to fall to very low levels causing pain) and prevented or abolished night rest pain."

01/01/2022 - "Mice receiving E-selectin/AAV2/2 gene therapy had reduced gangrene severity, increased limb and footpad perfusion, enhanced recruitment of endothelial progenitor cells, and improved performance on treadmill testing compared to control group. "
01/01/2022 - "Here, we tested the efficacy of modifying ischemic limb tissue by intramuscular administration of E-selectin/AAV2/2 (adeno-associated virus serotype 2/2) to modulate angiogenic and inflammatory responses in a murine hindlimb gangrene model. "
01/01/2021 - "Gangrene, revascularization, and limb function improved with E-selectin/adeno-associated virus gene therapy."
01/01/2023 - "Therapeutic priming of ischemic limb tissues with intramuscular E-selectin gene therapy promotes angiogenesis and reduces tissue loss in a murine hindlimb gangrene model. "
01/01/2022 - "E-Selectin/AAV2/2 Gene Therapy Alters Angiogenesis and Inflammatory Gene Profiles in Mouse Gangrene Model."

11/01/2012 - "Patient was managed with IV fluids, LMWH, FFP etc. Her general condition improved within 72 hours with no further progression of gangrene. "
05/01/1997 - "There were similar percentages of composite bypasses (IVH, 50%; LMWH, 46%), patients with tissue loss or gangrene (IVH, 56%; LMWH, 61%), and patients with prior ipsilateral bypass (IVH, 57%; LMWH, 56%) in each group. "
03/27/2007 - "The current evidence suggests that cancer patients are at increased risk from recurrent venous thrombosis and venous gangrene, and LMWH provides potential promise as a safe and effective measure in the management of such patients."

08/01/2014 - "Overall amputation-free survival was similar between patients managed with vs without thrombolysis (P = .61), but subgroup analysis of those patients without tissue loss or gangrene at the time of presentation revealed a trend toward improved amputation-free survival with use of thrombolysis, with 60-day amputation-free survival of 0.92 vs 0.75 (P = .12). "
01/01/2021 - "Model statistical tests showed that compared with traditional prevention schemes the use of the proposed models can increase the rate of positive results in the absence of lower extremities gangrene and reduce the possibility of relapse (recurrent changes by 42%, risk of amputation by 35%)."
07/01/2018 - "Patient responded well to the treatment and her platelet counts have been gradually improved, however, she developed gangrene of toe, for which amputation of distal phalanx of toe and nail excision was done, later in the disease course."
04/01/2014 - "By measuring the value of the Td 90%, ICGA tests can estimate the presence of the arterio-venous shunting in PND, which might be helpful for assessing the progression of foot ulceration with diabetes, gangrene and the need for amputation."
12/01/1998 - "Two patients with advanced distal forefoot gangrene ultimately required below-knee amputation despite the evidence of improved perfusion. "

11/01/2022 - "• In patients presenting with digital gangrene, an active search for an underlying connective tissue disorder is imperative, as this could result in timely initiation of appropriate therapy and can prove limb saving. "
11/01/2022 - "In patients presenting with digital gangrene, an active search for an underlying CTD is imperative, as this could result in timely initiation of appropriate limb-saving therapy. "
05/01/2021 - "Clinicians may consider this local therapy in the treatment of vasopressor-associated symmetric peripheral gangrene."
09/26/2019 - "There is an emerging evidence of an increased risk for developing Fournier´s gangrene (FG; a life-threatening complication) while under SGLT2 therapy. "
04/01/2016 - "Spinal cord stimulator is seen as a valid alternative in patients unsuitable for revascularisation after endovascular or surgical revascularisation failure and as adjuvant therapy in the presence of a functioning bypass in patients with extensive tissue loss and gangrene presenting a slow and difficult wound healing. "

12/01/1999 - "Early, wide and repeated debridement procedures reduced the mortality in patients with gangrene, and the best results of reconstruction were obtained with split-thickness skin grafts for total loss of penoscrotal cover and penile skin flaps for partial defects of the scrotum."
08/01/2012 - "This study sought to investigate the timing of gangrene tissue debridement and the safety of BMI in these patients. "
04/01/2023 - "We evaluated retrospectively adult inpatients with external genitalia gangrene who had a surgical debridement between 2010 and 2020 at CHU de Poitiers. "
03/01/2017 - "VSD combined with early adequate debridement can effectively localize the gangrene range, significantly reduce the frequency of changing dressings and shorten the hospitalization time of the patient, and therefore is a very effective adjuvant treatment of penile and scrotal gangrene. "
12/01/2001 - "Three patients were after extensive debridement of Fournierrís gangrene. "

05/01/2018 - "The aim of this study was to report long-term anal and urinary sphincter dysfunctions, sexual sequelae, and patients' quality of life after treatment of perineal gangrene. "
01/01/2020 - "This failure rate has prompted investigation into methods of determining physiologic procedural success before and after treatment, before clinically apparent outcomes occur such as gangrene. "
09/01/2007 - "After treatment and over a follow-up of 1 to 17 months (mean 6 months), the symptoms were relieved and all treated vessels were patent except 1 patient (3.3%) who had a gangrene foot and received limb amputation. "
01/01/1999 - "Traditional bone setter's gangrene (TBSG) is the term we use to describe the sequelae sometimes seen after treatment with native fracture splints. "
04/01/2017 - "Symmetrical peripheral gangrene in sepsis after treatment with inotropes."

08/01/1979 - "The efficacy of a new staged approach to AVR was tested against a canine ischemic limb preparation in which global ligation of ipsilateral collaterals inevitably led to limb gangrene. "
05/14/2014 - "Our case demonstrates that ligation of an injured iliac vein may induce phlegmasia cerulea dolens in a posttraumatic scenario; prompt reconstruction of the iliac vein to restore the venous drainage is an effective treatment for phlegmasia cerulea dolens with impending gangrene."
07/01/2014 - "Dry gangrene also occurred in the legs and paws of mice with ligation of the femoral artery proximal to the origin of the deep femoral artery branch. "
07/01/2014 - "In mice with ligation and transaction of the femoral artery proximal to the origin of the deep femoral artery branch, dry gangrene occurred in the whole hind-limb. "
08/01/2011 - "Immobilisation is much more important than tight ligature, which may cause gangrene. "