A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. The tumor may present clinically with HORNER SYNDROME or diarrhea due to ectopic production of vasoactive intestinal peptide. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p966)
Also Known As:
Gangliocytomas; Ganglioneuromas; Gangliocytoma
Networked: 311 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neuroblastoma
2. Paraganglioma (Paragangliomas)
3. Neoplasms (Cancer)
4. Pheochromocytoma
5. Ganglioneuroblastoma


1. Kofler, Barbara: 3 articles (09/2013 - 01/2006)
2. Ramani, Pramila: 3 articles (12/2012 - 10/2010)
3. Versteeg, Rogier: 3 articles (05/2009 - 04/2008)
4. Koster, Jan: 3 articles (05/2009 - 04/2008)
5. Waguespack, Steven G: 2 articles (03/2014 - 07/2005)
6. Erem, Cihangir: 2 articles (02/2014 - 01/2008)
7. Fukuzawa, Masahiro: 2 articles (02/2011 - 10/2008)
8. Oue, Takaharu: 2 articles (02/2011 - 10/2008)
9. Sperl, Wolfgang: 2 articles (01/2011 - 01/2006)
10. Jones, Neil: 2 articles (01/2011 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ganglioneuroma:
1. CobaltIBA
2. CatecholaminesIBA
3. Growth Hormone (Somatotropin)IBA
4. Keratins (Keratin)IBA
04/01/2005 - "This study presents a rare case of compound paraganglioma/ganglioneuroma with comprehensive immunohistochemical studies that reveal strong cytokeratin expression in all components. "
01/01/2015 - "The morphological and immunohistochemical studies revealed a composite tumor of paraganglioma and ganglioneuroma components, with immunopositivity for cytokeratin. "
01/01/1988 - "All the remaining tumors were neurogenic, showing either neurons and nerve fibers together with Schwann cells (ganglioneuromas and ganglioneuroblastomas) or endocrine cells (pheochromocytomas) reacting with VIP, PHM, NPY, enkephalin, somatostatin, neuron-specific enolase, synaptophysin, and MAP2 (but not cytokeratin, PP, or GRH) antibodies. "
11/01/1994 - "The monoclonal antibody KP-1 that recognizes the lysosome-associated glycoprotein CD68 was used together with antibodies to other antigens (actin, glial fibrillary acidic protein, keratin, neurofilaments, chromogranin, synaptophysin, S-100 protein, HMB-45, lysozyme, and HLA-DR) in a labeled streptavidin biotin immunoperoxidase method to phenotypically characterize 27 granular cell tumors, five schwannomas, five neurofibromas, two ganglioneuromas, three ganglioneuroblastomas, five carcinoid tumors, five malignant melanomas, and five examples of histiocytosis X. The neoplastic cells in all 27 of the granular cell tumors and four of the five schwannomas strongly stained for CD68, whereas none of the neurofibromas, ganglioneuromas, ganglioneuroblastomas, or carcinoid tumors contained CD68-positive tumor cells. "
5. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
6. HormonesIBA
7. Chromogranin AIBA
8. Nerve Growth Factor (NGF)IBA
9. Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)IBA
10. Cyclin D1IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Lasers (Laser)
3. Adrenalectomy
4. Thoracotomy
5. Laparotomy