gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)

An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

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Networked: 2049 relevant articles (43 outcomes, 149 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pompella, Alfonso: 30 articles (01/2015 - 02/2002)
2.	Paolicchi, Aldo: 29 articles (08/2014 - 02/2002)
3.	Franzini, Maria: 17 articles (01/2015 - 12/2004)
4.	Emdin, Michele: 16 articles (08/2014 - 04/2002)
5.	Corti, Alessandro: 14 articles (01/2015 - 12/2004)
6.	Carr, Brian I: 12 articles (10/2014 - 01/2007)
7.	Sultana, Sarwat: 10 articles (11/2011 - 04/2003)
8.	Lee, Duk-Hee: 9 articles (10/2014 - 02/2002)
9.	Ulmer, Hanno: 9 articles (04/2013 - 02/2005)
10.	Passino, Claudio: 9 articles (04/2012 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "Although experimental studies have shown that gamma-glutamyltransferase (GGT) has a role in tumor progression, epidemiologic evidence for a relationship between GGT and cancer incidence is limited. " 09/01/2011 - "Gamma-glutamyltransferase and risk of cancer in a cohort of 545,460 persons - the Swedish AMORIS study." 09/01/2011 - "Recent large epidemiologic population-based studies identified gamma-glutamyltransferase (GGT) as a marker for increased cervical cancer incidence. " 10/01/1992 - "In our study, in contrast with the previous report, all animals that had survived some initial toxicity were found to have developed hepatic tumors or hyperplastic gamma-glutamyltransferase-positive foci a year later. " 02/01/1986 - "Histochemical studies of tumors revealed a marked increase in the phenotypic expression of the oncofetal enzyme, gamma-glutamyl transpeptidase (GGT) in the tumors of treated rats."
2.	Liver Diseases (Liver Disease) 09/01/2012 - "While serum gamma-glutamyltransferase (GGT) enzyme activity is a well established biomarker of excessive alcohol consumption and liver dysfunction, recent studies have also implicated it as a predictor of morbidity due to extrahepatic causes. " 07/01/2006 - "However, patients included in these studies belong to a heterogeneous population, which may not represent true cases of ICP since some reports include patients diagnosed in the first trimester of pregnancy, with elevated serum levels of gamma-glutamyl transpeptidase and clear evidence of chronic liver disease. " 03/01/1985 - "This study shows that serum gamma-glutamyl transpeptidase is persistently elevated in patients with clinically obvious liver injury, but only in 22% of chronic alcoholics without significant liver disease." 09/01/1974 - "A histochemical study on the activity of gamma-glutamyl transpeptidase in liver disease." 07/15/1972 - "[Study of gamma-glutamyl transpeptidase in liver diseases]."
3.	Cholestasis 01/01/2013 - "In this report we compared the accuracy of mutation detection for MR with FS in a group of patients with 'low-normal' gamma glutamyl transpeptidase (gGT) cholestasis without known molecular diagnoses. " 01/01/2013 - "In this report we compared the accuracy of mutation detection for MR with FS in a group of patients with 'low-normal' gamma glutamyl transpeptidase (gGT) cholestasis without known molecular diagnoses. " 09/01/2010 - "Findings of cholestasis with normal serum [gamma]-glutamyltransferase activity and total bile acid concentration indicated the need for definitive bile acid analysis. " 05/01/2010 - "Despite the cholestasis, serum gamma-glutamyltransferase activity is normal or reduced. " 01/01/2010 - "Values of gamma-glutamyltransferase (GGT) (10 times higher than the limit of normality) presented sensitivity of 56.3%, specificity of 91.5%, and accuracy of 75.7% for the diagnosis of extra-hepatic cholestasis. "
4.	Pruritus (Itching) 08/01/2008 - "Individuals with inborn errors of bile acid synthesis generally present with the hallmark features of normal or low serum bile acid concentrations, normal gamma-glutamyl transpeptidase concentrations and the absence of pruritus. " 01/01/1998 - "These data suggest that although UDCA therapy improves pruritus and results in a reduction in ALT and gamma-glutamyl transpeptidase, UDCA therapy did not improve quantitative measures of hepatic function in children with intrahepatic cholestasis." 09/10/2012 - "The patient presented at the age of 4 years with a history of severe pruritus, elevated serum gamma-glutamyltransferase and bile acid levels since several years suggesting the diagnosis of progressive familial intrahepatic cholestasis type 3 (PFIC-3) due to defects in MDR3. " 07/06/2011 - "A 75 year old woman presented with long-lasting pruritus and elevation of serum levels of alkaline phosphatase and gamma-glutamyl transpeptidase (GGT). " 01/01/2003 - "To detect PBC early, young and middle-aged women with unexplained weakness or skin pruritus should undergo a comprehensive examination including measurements of GGTP, AP, AMA, IgM, morphological investigation of liver tissue. "
5.	Fatty Liver 03/01/2010 - "Aims of our study were to determine the prevalence of liver lesions (elevated alanin aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) above normal range and ultrasound signs of liver steatosis) among the study group of patients with at least one metabolic risk factor, to compare it with the control group with no risk factor, to investigate it's association with the number of metabolic risk factors and to identify it's closest independent predictors. " 04/01/2004 - "This study aimed to determine whether metabolic syndrome is directly or indirectly, through fatty liver, associated with elevated gamma-glutamyl transpeptidase (GGT) levels in Japanese women. " 01/01/2015 - "Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque." 01/01/2015 - "We investigated the relationship of television (TV) viewing time with serum gamma-glutamyltransferase (GGT) and Fatty Liver Index (FLI), and ultrasonographically assessed liver fat. " 05/01/2012 - "Fatty liver index, gamma-glutamyltransferase, and early carotid plaques."

Related Drugs and Biologics

1.	Alkaline Phosphatase
2.	Alanine Transaminase (SGPT)
3.	Bilirubin
4.	Aspartate Aminotransferases (Aspartate Transaminase)
5.	Cholesterol
6.	Glutathione (Reduced Glutathione)
7.	Enzymes
8.	Bile Acids and Salts (Bile Acids)
9.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
10.	Creatinine

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Transplants (Transplant)
4.	Liver Transplantation
5.	Transplantation (Transplant Recipients)