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Gallopamil (D600)

Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.

Also Known As:

D600; Abbott Brand of Gallopamil Hydrochloride; D-600; Elgiprona; Gallobeta; Gallopamil Hydrochloride; Prebet; Procorum; betapharm Brand of Gallopamil Hydrochloride; ct-Arzneimittel Brand of Gallopamil Hydrochloride; gallopamil von ct; D 600; Hydrochloride, Gallopamil; ct Arzneimittel Brand of Gallopamil Hydrochloride; Methoxyverapamil; Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-

Networked: 202 relevant articles (15 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Ethylamines: 5
    - Phenethylamines: 14
      - Verapamil: 5275
        Gallopamil: 202
        D 890
        norgallopamil

Experts

1.	Ozier, Annaig: 2 articles (04/2015 - 06/2011)
2.	Marthan, Roger: 2 articles (04/2015 - 06/2011)
3.	Girodet, Pierre-Olivier: 2 articles (04/2015 - 06/2011)
4.	Berger, Patrick: 2 articles (04/2015 - 06/2011)
5.	Weiss, James N: 2 articles (10/2004 - 10/2002)
6.	Ting, Chih-Tai: 2 articles (10/2004 - 10/2002)
7.	Lin, Shien-Fong: 2 articles (10/2004 - 10/2002)
8.	Wu, Tsu-Juey: 2 articles (10/2004 - 10/2002)
9.	Chen, Peng-Sheng: 2 articles (10/2004 - 10/2002)
10.	Gellert, Paul R: 1 article (07/2015)

Related Diseases

1.	Angina Pectoris 09/01/1992 - "Gallopamil appears to be safe, well tolerated and effective in the long term control of angina pectoris; its effects are fully developed at 3 months and persist unchanged after 2 years. " 01/01/1992 - "These data suggest that gallopamil SR is effective in reducing exercise-inducible ST-segment depression and increasing exercise tolerance with no serious adverse effects in patients with stable angina pectoris." 10/01/1992 - "Comparison of acute and steady-state conditions of gallopamil therapy in stable angina pectoris." 09/01/1992 - "[Long-term treatment of stable angina pectoris with gallopamil]." 01/01/1992 - "The anti-ischemic properties and tolerability of a slow-release formulation (SR) of gallopamil were investigated in 118 patients with exercise-inducible ST-segment depression and stable angina pectoris in this double-blind, randomized, placebo-controlled, multicenter study. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/1992 - "Reduction of myocardial ischemia by gallopamil: a dual-isotope study with thallium-201 and iodine-123 phenylpentadecanoic acid." 01/01/1992 - "Gallopamil modified the circadian distribution of ischemic episodes by modifying the morning peak of transient myocardial ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1992 - "These results suggest that intracoronary application of gallopamil attenuates myocardial ischemia during PTCA." 01/01/1992 - "Such action might contribute to the beneficial effect of gallopamil in the treatment of myocardial ischemia." 10/01/1991 - "Exercise cardiovascular responses to gallopamil in ischemic heart disease."
3.	Contracture 12/01/1989 - "After a step concentration change in the medium during contracture, the effects of Ca2+ or D600 were detectable only after a delay of 9 and 18 sec, respectively. " 11/01/1989 - "D 600 (10(-7) to 10(-4) M), a blocker of voltage-dependent Ca2+ influx, suppressed the response to Na removal, but 10(-4) M D 600 did not completely block the contracture. " 09/01/1988 - "(2) D600 only slightly reduced the amplitude of contractures evoked with 30 or 95 mM K-Ringer's. " 09/01/1988 - "(1) The effect of 30 microM D600 on the amplitude and time course of isometric contractures was studied in single slow fibres of Rana temporaria. " 09/01/1987 - "After pretreatment with D600 (30 microM) a single (conditioning) K-contracture was sufficient to 'paralyze' the fibres (cf. "
4.	Ischemia 01/01/1989 - "It was observed that both dosages improved exercise tolerance (355 +/- 95 sec after placebo; 462 +/- 78 sec, p less than 0.01 and 511 +/- 97 sec, p less than 0.01 after the two doses) while the time taken to produce ischemia (-1 mm ST depression) was significantly prolonged only by the higher dose of the drug (204 +/- 101 sec after placebo; 324 +/- 135 sec after gallopamil 150 mg, p less than 0.05). " 04/01/1995 - "We evaluated the efficacy and safety of gallopamil 150 mg daily in middle-aged and elderly patients with stable exertional ischemia, using a medium-term randomized double-blind cross-over placebo-controlled trial. " 04/01/1995 - "Electrocardiographic signs of ischemia were favorably influenced by gallopamil in both groups (from 1.39 +/- 0.5 mm to 0.76 +/- 0.73 mm; p < 0.001 in the middle-aged patients and from 1.5 +/- 0.34 mm to 1 +/- 0.76 mm; p < 0.01 in the elderly patients).(ABSTRACT TRUNCATED AT 250 WORDS)" 04/01/1995 - "Age-response effectiveness of gallopamil for the treatment of myocardial exertional ischemia. " 12/01/1990 - "In conclusion, gallopamil has a beneficial effect on atrial pacing induced ischemia: it increases pacing time to ischemic threshold and reduces during ischemia the extent of dysfunctional myocardium."
5.	Reperfusion Injury 01/01/1989 - "Protective effects of gallopamil against ischemia and reperfusion damage." 02/01/1984 - "The protective effects of D-600 and propranolol on reperfusion injury in the anaesthetized rabbit."

Related Drugs and Biologics

1.	Calcium
2.	Verapamil (Calan)
3.	Nifedipine (Adalat)
4.	Atenolol (Tenormin)
5.	esmolol (Brevibloc)
6.	isosorbide-5-mononitrate (Ismo)
7.	Propranolol (Inderal)
8.	Norepinephrine (Noradrenaline)
9.	Carbachol (Carbastat)
10.	Nicotinic Agonists

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3.	Ligation
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5.	Transplantation (Transplant Recipients)