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Gallbladder Neoplasms (Gallbladder Cancer)

Subscribe to New Research on Gallbladder Neoplasms

Tumors or cancer of the gallbladder.

Also Known As:

Gallbladder Cancer; Cancer of the Gallbladder; Gall Bladder Cancer; Neoplasms, Gallbladder; Bladder Cancer, Gall; Bladder Cancers, Gall; Cancer, Gall Bladder; Cancer, Gallbladder; Cancers, Gall Bladder; Cancers, Gallbladder; Gall Bladder Cancers; Gallbladder Cancers; Gallbladder Neoplasm; Neoplasm, Gallbladder; Cancer of Gallbladder

Networked: 1029 relevant articles (35 outcomes, 125 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Stomach Neoplasms (Stomach Cancer)
4.	Cholangiocarcinoma
5.	Bile Duct Neoplasms (Bile Duct Cancer)

Experts

1.	Mittal, Balraj: 24 articles (09/2014 - 02/2004)
2.	Cao, Yang: 14 articles (12/2015 - 01/2013)
3.	Hsing, Ann W: 14 articles (10/2013 - 10/2002)
4.	Weng, Hao: 13 articles (10/2015 - 01/2013)
5.	Srivastava, Anvesha: 13 articles (02/2013 - 09/2007)
6.	Rashid, Asif: 12 articles (05/2010 - 10/2002)
7.	Jiang, Lin: 11 articles (12/2015 - 01/2013)
8.	Choudhuri, Gourdas: 11 articles (06/2010 - 02/2004)
9.	Shen, Ming-Chang: 11 articles (05/2010 - 10/2002)
10.	Gao, Yu-Tang: 11 articles (05/2010 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gallbladder Neoplasms:

1.	gemcitabine FDA Link 07/01/2011 - "The findings suggest that gemcitabine plus S-1 treatment may be effective against advanced gallbladder cancer." 09/01/2000 - "[Efficacy of gemcitabine in the gallbladder cancer. " 04/01/2007 - "Recently, several studies have reported clinical trials using gemcitabine as treatment for advanced gallbladder cancers. " 04/01/2015 - "Gemcitabine (GEM) is one of the first-line drugs in the treatment of gallbladder cancer (GBC), although the therapeutic effect is not sustained due to resistance to the drug over time. " 11/01/2014 - "Gemcitabine has been more and more widely used for the treatment of gallbladder cancer; however, the response rate is not satisfactory. "
2.	Fluorouracil (Carac)FDA LinkGeneric 12/01/1993 - "The results suggest that treatment with 5-FU and LV is effective for gallbladder cancer." 12/01/1993 - "[Efficacy of 48-hour infusion of 5-fluorouracil for gall bladder cancer]." 12/01/2003 - "We undertook this study to determine whether the introduction of the wild type p53 gene into GBCE (human gallbladder cancer cell line with a heterozygous p53 mutation) by an adenoviral vector could increase the sensitivity of the cell to 5-FU, a commonly used drug in the treatment of gallbladder cancer. " 02/01/2000 - "In this study, we evaluated the clinical effects of low-dose CDDP and 5-FU (low-dose FP therapy) in patients with advanced gallbladder cancer. " 09/01/1996 - "[Study of hepatic arterial chemoinfusion with continuous CDDP, 5-FU low dose administration for advanced gallbladder cancer]."
3.	oxaliplatin (Eloxatin)FDA LinkGeneric 09/01/2013 - "A Multicenter Phase II Trial of Gemcitabine Plus Oxaliplatin in Unresectable Gallbladder Cancer." 02/01/2010 - "A phase II study of gemcitabine and oxaliplatin (Oxigem) in unresectable gall bladder cancer." 09/01/2013 - "The authors studied the activity and tolerability of a gemcitabine and oxaliplatin (GEMOX) combination in unresectable gallbladder cancer (GBC). " 03/01/2010 - "The aim of this study was to evaluate the efficacy and safety of the combination chemotherapy with gemcitabine and oxaliplatin (GEMOX) in patients with BTCs including gall bladder cancer. " 03/01/2010 - "Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial."
4.	Leucovorin (Folinic Acid)FDA Link 04/01/2003 - "In conclusion, 5-FU and folinic acid (Mayo Clinic regimen) is ineffective in the management of patients with advanced gallbladder cancer, and further trials with this regimen are not recommended." 04/01/2003 - "We evaluated the efficacy and toxicity of 5-fluorouracil (5-FU) and folinic acid (Mayo Clinic regimen) in previously untreated patients with advanced gallbladder cancer. " 04/01/2003 - "Prospective evaluation of efficacy and toxicity of 5-fu and folinic acid (Mayo Clinic regimen) in patients with advanced cancer of the gallbladder." 04/01/2001 - "[A case of inoperable advanced gall bladder cancer responding to intra-arterial infusion of 5-fluorouracil (5-FU) and leucovorin (LV)]." 10/20/2010 - "We designed this study to evaluate efficacy of modified gemcitabine and oxaliplatin (mGEMOX) over best supportive care (BSC) or fluorouracil (FU) and folinic acid (FA) in unresectable gall bladder cancer (GBC). "
5.	Xanthogranulomatous cholecystitisIBA 10/01/2013 - "Diagnostic performance [area under ROC curve (Az)] of both observers improved significantly after additional review of DWI; Az improved from 0.737 to 0.930 (p = 0.027) for observer 1 and from 0.675 to 0.938 (p = 0.008) for observer 2. Addition of DWI to conventional MRI improves discrimination between xanthogranulomatous cholecystitis and the wall-thickening type of gallbladder cancer." 01/01/2012 - "The present study aimed to investigate the characteristics of xanthogranulomatous cholecystitis masquerading as gallbladder cancer that could potentially aid in the correct diagnosis of this condition. " 09/21/2015 - "To compare cases of xanthogranulomatous cholecystitis (XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical options. " 09/21/2015 - "Xanthogranulomatous cholecystitis: Difficulty in differentiating from gallbladder cancer." 06/01/2015 - "Xanthogranulomatous cholecystitis is an unusual inflammatory process of the gallbladder which is difficult to diagnose and manage and may be confused with gallbladder cancer. "
6.	Sirolimus (Rapamycin)FDA Link 04/15/2007 - "In this study, we used BK5.erbB2 transgenic mice as an animal model to examine the therapeutic effect of rapamycin as a potential treatment for gallbladder cancer. " 07/01/2014 - "We found that inhibition of mTOR using shRNAs and rapamycin inhibited EMT in GBC-SD gallbladder cancer cells. " 04/15/2007 - "Based on our results using a novel genetically engineered mouse model and the fact that the Akt/mTOR pathway is activated in human gallbladder cancer, rapamycin and related drugs may be effective therapeutic agents for the treatment of human gallbladder cancer." 04/15/2007 - "Finally, immunofluorescence staining revealed elevated phosphorylated Akt (Ser(473)) and phosphorylated mammalian target of rapamycin (mTOR; Ser(2448)) in human gallbladder cancer compared with normal gallbladder tissue. " 04/15/2007 - "Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model."
7.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2015 - "Targeting gallbladder cancer: hyaluronan sensitizes cancer cells to chemo-therapeutics." 01/01/2015 - "Hyaluronan (HA) was shown in our previous study to significantly improve the myxoma virus distribution via promoting the MMP-9 production, which degrades collagen IV. We demonstrated that HA increased the chemo-sensitivity of gallbladder cancer cells both in vitro and in vivo. " 01/01/2014 - "Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo." 02/01/2004 - "Protection of trocar sites from gallbladder cancer implantation by sodium hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a murine model [corrected]."
8.	erlotinib (CP 358,774)FDA Link 01/01/2010 - "A 67 year old man with metastatic gallbladder cancer involving the liver and abdominal lymph nodes was treated with gemcitabine (1000 mg/m2) on day 1 and 8 every 21 days as well as daily erlotinib (100 mg). " 01/01/2010 - "Complete response in gallbladder cancer to erlotinib plus gemcitabine does not require mutation of the epidermal growth factor receptor gene: a case report." 02/01/2012 - "In this open label, randomised, phase 3 trial, we randomly assigned patients (in a 1:1 ratio) with metastatic biliary-tract cancer (cholangiocarcinoma, gallbladder cancer, or ampulla of Vater cancer) to receive either first-line treatment with chemotherapy alone (gemcitabine 1000 mg/m(2) on day 1 and oxaliplatin 100 mg/m(2) on day 2) or chemotherapy plus erlotinib (100 mg daily). "
9.	Carcinoembryonic AntigenIBA 01/01/2014 - "Preoperative prediction of survival in resectable gallbladder cancer by a combined utilization of CA 19-9 and carcinoembryonic antigen." 01/01/1996 - "The aim of this work was to assess the diagnostic yield of serum tumoral markers, Ca 19-9 and carcinoembryonic antigen, in patients with gallbladder cancer. " 01/01/1996 - "[CAA 19-9 and carcinoembryonic antigen in gallbladder cancer]." 11/01/1992 - "The immunohistochemical expression of CA19-9, epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA) was studied in 103 tissue samples of gallbladder cancer and 25 samples of non tumoral gallbladder lesions. " 11/01/1992 - "[Gallbladder cancer: immunohistochemical expression of CA-19-9, epithelial membrane antigen, dupan-2 and carcinoembryonic antigen]."
10.	TegafurIBA 09/01/1988 - "[Successful treatment with tegafur and PSK in a patient with gallbladder cancer]." 02/01/2013 - "In January 2007, the patient underwent curative resection for gallbladder cancer (T2N1M0, Stage III), and tegafur/uracil was administered for a year as adjuvant chemotherapy. " 09/01/1988 - "These findings suggested gallbladder cancer with liver metastasis, and he was soon started on tegafur rectally (1,000 mg/day) and PSK orally (3.0 g/day). " 09/01/1988 - "Since few antineoplastic agents have been reported to be effective against gallbladder cancer, tegafur and PSK might be a good combination for this disease." 09/01/1988 - "Four patients with gallbladder cancer and two with bile duct cancer were treated with mitomycin C, carboquone, 5-fluorouracil and OK-432 (MQF-OK therapy) plus tegafur (FT) or UFT. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/2005 - "Thus intra-aortic infusion chemotherapy may be beneficial for the treatment of gallbladder cancer associated with para-aortic lymph node involvement." 11/01/1994 - "We conclude that arterial infusion chemotherapy is effective for advanced gallbladder cancer, and that a more effective regimen and adjuvant therapy should be established." 01/01/2005 - "The present case suggests that combination of chemotherapy protocols is effective for clinical management of gallbladder cancer recurrence, which is generally considered to be difficult to manage with chemotherapy." 05/01/1994 - "It appeared that this chemotherapy is effective for gallbladder cancer." 12/01/2009 - "Further improvement in the management of gallbladder cancer will need integration of systemic chemotherapy with radical surgery."
2.	Cholecystectomy 09/01/2000 - "Extended cholecystectomy is the only chance of a cure for patients with locally advanced cancer of the gallbladder. " 07/01/2014 - "The study included a total of 104 patients, 40 of whom had incidental gallbladder cancer following cholecystectomy. " 04/01/2012 - "This study was undertaken to compare patients in whom gallbladder cancer (GBC) was diagnosed after cholecystectomy on HPE with GBC patients in whom the gallbladder was not sent for HPE and who therefore presented late with symptoms. " 11/01/2010 - "This study performed a TP53 gene investigation by PCR-SSCP and direct sequencing using both bile supernatants and tissue samples from cholecystectomy specimens lacking gallbladder cancer, in order to investigate gallbladder carcinogenesis. " 09/01/2010 - "From August 2005 to March 2009, 23 patients affected by gallbladder cancer detected after the study of a cholecystectomy specimen underwent laparoscopy as part of their management. "
3.	Lymph Node Excision (Lymph Node Dissection) 01/01/2004 - "Although the best chance of cure for gallbladder cancer remains incidental discovery, radical resection of the gallbladder, with the adjacent liver, adherent structures, plus a regional lymphadenectomy, has been suggested to improve survival. " 02/01/2015 - "The purpose of this study is to evaluate the different extent of lymph node dissection for N2 stage gallbladder cancer patients. " 03/01/2012 - "The present study describes the technique of a regional lymphadenectomy for gallbladder cancer, as practiced by the author. " 04/01/2006 - "Although no data from prospective, randomized studies are available, resection of the gallbladder and adjacent liver with or without the extrahepatic bile ducts and with a regional lymph node dissection is the operative approach recommended for selected patients with gallbladder cancer." 12/01/2015 - "We present a video of a totally laparoscopic liver resection (segments 5 and 4b) with regional lymphadenectomy in a patient with an incidental gallbladder cancer. "
4.	Laparoscopic Cholecystectomy 01/01/2002 - "Is frozen section effective for diagnosis of unsuspected gallbladder cancer during laparoscopic cholecystectomy?" 07/01/2003 - "The aim of the study was to examine the risk of the dissemination in patients with unsuspected gallbladder cancer diagnosed after laparoscopic cholecystectomy (LC). " 09/01/2001 - "We present our experience with intra-abdominal malignancies different from gallbladder cancer not diagnosed preoperatively and undiscovered during laparoscopic cholecystectomy This study involved retrospective analysis of 10 patients hospitalized in the Second Department of General Surgery between 1993 and 2000. " 08/01/2000 - "The purpose of this study was to examine the long-term prognosis of patients with unexpected gallbladder cancer diagnosed after laparoscopic cholecystectomy (LC). " 09/01/1999 - "This study was designed to assess the treatment of patients in whom gallbladder cancer was diagnosed in the course of histological examination of their gallbladders, which were removed during laparoscopic cholecystectomy. "
5.	Radiotherapy 07/01/2013 - "To summarize the experiences in gallbladder cancer treatment, evaluate the efficacy of postoperative radiotherapy, and investigate the method of improving the survival of gallbladder cancer patients. " 07/01/2013 - "[Analysis of the efficacy of postoperative radiotherapy in gallbladder cancer]." 07/01/2013 - "One hundred and twenty-seven gallbladder cancer patients, treated in our center by radical resection (84 cases) and combined with postoperative radiotherapy (43 cases), between June 2003 to December 2009 were included in this study. " 03/01/2015 - "[Current status and prospects of radiotherapy for gallbladder cancer]." 10/01/2014 - "To evaluate the results of postoperative radiotherapy (PORT) and to identify prognostic factors for gallbladder cancer (GBC). "