Galactokinase

An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-galactose. Galactosamine can also act as the acceptor. A deficiency of this enzyme results in GALACTOSEMIA. EC 2.7.1.6.

Also Known As:

Networked: 73 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Reece, Richard J: 4 articles (03/2005 - 04/2003)
2.	Timson, David J: 4 articles (03/2005 - 04/2003)
3.	Hayashi, Shinichiro: 2 articles (04/2013 - 11/2012)
4.	Satou, Tadaaki: 2 articles (04/2013 - 11/2012)
5.	Koike, Kazuo: 2 articles (04/2013 - 11/2012)
6.	Masuo, Yoshinori: 2 articles (04/2013 - 11/2012)
7.	Shin, Yoon S: 2 articles (10/2011 - 05/2002)
8.	Holden, Hazel M: 2 articles (03/2005 - 08/2003)
9.	Thoden, James B: 2 articles (03/2005 - 08/2003)
10.	Thoden, J B: 2 articles (10/2004 - 06/2001)

Related Diseases

1.	AIDS-Related Complex (ARC) 04/01/2013 - "After the EPM test, mice were dissected and changes in the stress-induced biomarkers within the brain were investigated by examining the amounts of fast nerve growth factor receptor (NGFR) and activity regulated cytoskeletal-associated protein (Arc) gene expression, and brain-derived neurotrophic factor (BDNF) and galactokinase 1 (GLK1) protein expression. " 11/01/2012 - "To understand the molecular mechanisms of action of aromatic compounds on emotional responses, we evaluated the stress-induced changes in mouse brain and the efficacy of inhaled essential oil from Lavandula officinalis (LvEO) using two approaches: a behavioral test, and examining the expression levels of selected genes {fast nerve growth factor receptor (NGFR) mRNA, activity regulated cytoskeletal-associated protein (Arc) mRNA} and proteins {galactokinase 1 (GLK1) and brain-derived neurotrophic factor (BDNF)}. "
2.	Cataract (Cataracts) 04/01/1990 - "[Studies on blood galactokinase of patients with presenile and senile cataracts]." 10/01/2012 - "200 infants with congenital cataracts were screed for galactokinase (GALK) enzyme deficiency. " 06/01/2005 - "Cloning of canine galactokinase (GALK1) and evaluation as a candidate gene for hereditary cataracts in Labrador retrievers." 08/26/2003 - "To investigate possible associations between sequence changes in the galactokinase gene (GALK1) and age-related cataract in a European population. " 08/26/2003 - "Galactokinase gene mutations and age-related cataract. "
3.	Trisomy (Trisomies) 01/01/1965 - "[Studies on the activity of galactokinase in the blood of normal persons and of patients with GDo trisomy]." 01/01/1970 - "Elevated galactokinase activity in blood cells of patients with G-trisomy: a belated correction." 09/12/1964 - "ENHANCEMENT OF ERYTHROCYTE-GALACTOKINASE ACTIVITY IN LANGDON-DOWN TRISOMY."
4.	Cardiomyopathies (Cardiomyopathy) 10/01/2014 - "We performed a targeted genetic screen for modifiers of calcineurin-induced cardiac enlargement based on previous calcineurin studies in the fly and identified galactokinase as a novel modifier of calcineurin-induced cardiomyopathy. " 10/01/2014 - "Collectively, we generated a model for discovering novel modifiers of calcineurin-induced cardiac enlargement in the fly and identified galactokinase as a previously unknown regulator of calcineurin-induced cardiomyopathy in adult Drosophila. " 10/01/2014 - "Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila." 10/01/2014 - "Genomic deficiencies spanning the galactokinase locus, transposable elements that disrupt galactokinase, and cardiac-specific RNAi knockdown of galactokinase suppressed constitutively active calcineurin-induced cardiomyopathy. "
5.	Galactosemias (Galactosemia) 05/01/2013 - "The search for inhibitors of galactokinase (GALK) enzyme is interesting for their possible therapeutic application capable to alleviate symptoms in people with classic galactosemia. " 05/20/2009 - "The defect in human galactokinase can result in the disease of galactosemia. " 03/11/2005 - "Approximately 20 mutations have now been identified in human galactokinase, which result in the diseased state referred to as Type II galactosemia. " 03/11/2005 - "Molecular structure of human galactokinase: implications for type II galactosemia." 10/01/2004 - "Galactokinase: structure, function and role in type II galactosemia."

Related Drugs and Biologics

1.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Proteins (Proteins, Gene)
4.	activity regulated cytoskeletal-associated protein
5.	Messenger RNA (mRNA)
6.	Calcineurin
7.	galactose-1-phosphate
8.	Galactose (Galactopyranose)
9.	UDPglucose-Hexose-1-Phosphate Uridylyltransferase (Galactose 1 P Uridyltransferase)
10.	Enzymes

Related Therapies and Procedures

1.	Lenses