Galactokinase

An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-galactose. Galactosamine can also act as the acceptor. A deficiency of this enzyme results in GALACTOSEMIA. EC 2.7.1.6.

Also Known As:

Networked: 96 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Timson, David J: 7 articles (03/2017 - 04/2003)
2.	Lai, Kent: 4 articles (01/2021 - 06/2008)
3.	Tang, Manshu: 4 articles (01/2021 - 06/2008)
4.	Reece, Richard J: 4 articles (03/2005 - 04/2003)
5.	Berry, Gerard T: 2 articles (01/2020 - 01/2011)
6.	Huang, Meilan: 2 articles (03/2017 - 02/2016)
7.	Fridovich-Keil, J L: 2 articles (01/2017 - 06/2001)
8.	Hayashi, Shinichiro: 2 articles (04/2013 - 11/2012)
9.	Koike, Kazuo: 2 articles (04/2013 - 11/2012)
10.	Masuo, Yoshinori: 2 articles (04/2013 - 11/2012)

Related Diseases

1.	AIDS-Related Complex (ARC) 04/01/2013 - "After the EPM test, mice were dissected and changes in the stress-induced biomarkers within the brain were investigated by examining the amounts of fast nerve growth factor receptor (NGFR) and activity regulated cytoskeletal-associated protein (Arc) gene expression, and brain-derived neurotrophic factor (BDNF) and galactokinase 1 (GLK1) protein expression. " 11/01/2012 - "To understand the molecular mechanisms of action of aromatic compounds on emotional responses, we evaluated the stress-induced changes in mouse brain and the efficacy of inhaled essential oil from Lavandula officinalis (LvEO) using two approaches: a behavioral test, and examining the expression levels of selected genes {fast nerve growth factor receptor (NGFR) mRNA, activity regulated cytoskeletal-associated protein (Arc) mRNA} and proteins {galactokinase 1 (GLK1) and brain-derived neurotrophic factor (BDNF)}. "
2.	Cataract (Cataracts) 04/01/1990 - "[Studies on blood galactokinase of patients with presenile and senile cataracts]." 06/01/2005 - "Cloning of canine galactokinase (GALK1) and evaluation as a candidate gene for hereditary cataracts in Labrador retrievers." 08/26/2003 - "To investigate possible associations between sequence changes in the galactokinase gene (GALK1) and age-related cataract in a European population. " 08/26/2003 - "Galactokinase gene mutations and age-related cataract. " 04/01/2001 - "A genetic factor for age-related cataract: identification and characterization of a novel galactokinase variant, "Osaka," in Asians."
3.	Trisomy (Trisomies) 01/01/1965 - "[Studies on the activity of galactokinase in the blood of normal persons and of patients with GDo trisomy]." 01/01/1970 - "Elevated galactokinase activity in blood cells of patients with G-trisomy: a belated correction." 03/06/1965 - "ENHANCEMENT OF ERYTHROCYTE-GALACTOKINASE ACTIVITY IN LANGDON-DOWN TRISOMY." 09/12/1964 - "ENHANCEMENT OF ERYTHROCYTE-GALACTOKINASE ACTIVITY IN LANGDON-DOWN TRISOMY."
4.	Cardiomyopathies (Cardiomyopathy) 10/01/2014 - "We performed a targeted genetic screen for modifiers of calcineurin-induced cardiac enlargement based on previous calcineurin studies in the fly and identified galactokinase as a novel modifier of calcineurin-induced cardiomyopathy. " 10/01/2014 - "Collectively, we generated a model for discovering novel modifiers of calcineurin-induced cardiac enlargement in the fly and identified galactokinase as a previously unknown regulator of calcineurin-induced cardiomyopathy in adult Drosophila. " 10/01/2014 - "Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila." 10/01/2014 - "Genomic deficiencies spanning the galactokinase locus, transposable elements that disrupt galactokinase, and cardiac-specific RNAi knockdown of galactokinase suppressed constitutively active calcineurin-induced cardiomyopathy. "
5.	Galactosemias (Galactosemia) 01/01/2021 - "Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia." 01/01/2018 - "Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2." 05/20/2009 - "The defect in human galactokinase can result in the disease of galactosemia. " 03/11/2005 - "Approximately 20 mutations have now been identified in human galactokinase, which result in the diseased state referred to as Type II galactosemia. " 03/11/2005 - "Molecular structure of human galactokinase: implications for type II galactosemia."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	activity regulated cytoskeletal-associated protein
5.	Messenger RNA (mRNA)
6.	Volatile Oils (Essential Oils)
7.	Calcineurin
8.	Enzymes
9.	Galactose (Galactopyranose)
10.	galactose-1-phosphate

Related Therapies and Procedures

1.	Therapeutics
2.	Lenses
3.	Diet Therapy (Therapy, Diet)