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Fusidic Acid (Fucithalmic)

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An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.

Also Known As:

Fucithalmic; Fusidin; Sodium Fusidate; Fusidate Sodium; Fusidic Acid, Sodium Salt; Silver Fusidate; Stanicide; Acid, Fusidic; Fusidate, Silver; Fusidate, Sodium; Sodium, Fusidate; 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-

Networked: 395 relevant articles (46 outcomes, 76 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Struelens, Marc J: 4 articles (01/2013 - 09/2002)
2.	Peacock, Sharon J: 3 articles (05/2015 - 01/2009)
3.	Rørtveit, Sverre: 3 articles (12/2014 - 09/2003)
4.	Frimodt-Møller, Niels: 3 articles (09/2013 - 08/2002)
5.	Fernandes, Prabhavathi: 3 articles (06/2011 - 05/2011)
6.	Denis, Olivier: 3 articles (04/2009 - 09/2002)
7.	Olsson-Liljequist, B: 3 articles (01/2006 - 01/2002)
8.	Nicoletti, F: 3 articles (08/2005 - 12/2000)
9.	Bendtzen, K: 3 articles (08/2005 - 12/2000)
10.	Eady, E A: 3 articles (05/2003 - 01/2000)

Related Diseases

1.	Infection 06/01/2011 - "A phase 1 trial of fusidic acid (CEM-102), an oral fusidane class antibiotic under development for treatment of gram-positive acute bacterial skin and skin structure infections, evaluating pharmacokinetics and safety is described. " 02/01/1986 - "The studies suggest that sodium fusidate does have antigiardial activity and in view of its relative freedom from teratogenic and other toxic effects may be useful in pregnancy when other antigiardial agents are contra-indicated or as an adjunct in combination therapy when other single agents have failed to eradicate infection." 12/01/2015 - "Fusidic acid (FA) is widely employed in the treatment of complicated skin infections caused by Staphylococcus aureus. " 10/01/2015 - "A topical pharmaceutical cream containing the active pharmaceutical ingredients (APIs) betamethasone-17-valerate and fusidic acid has been developed for the treatment of inflammatory skin conditions and associated secondary infections. " 01/01/2015 - "In a murine model of MRSA skin infection, the compound was more effective than fusidic acid in bringing down the bacterial burden. "
2.	Impetigo 08/16/2013 - "Fusidic acid ointment was recommended as first-line treatment for localised impetigo. " 01/01/2010 - "Similarly, plain fusidic acid cream or ointment used two or three times daily in SSTIs such as impetigo are clinically and bacteriologically effective, with minimal adverse events. " 10/01/2008 - "Last year, we concluded that topical fusidic acid should be first-line treatment for impetigo. " 01/26/2002 - "Fusidic acid cream in the treatment of impetigo in general practice: double blind randomised placebo controlled trial." 05/01/2015 - "Antibiotic resistance to specifically fusidic acid was more common in 2005 impetigo patients (22.8%) versus 2011 (5%) (p = 0.078). "
3.	Staphylococcal Infections 01/01/1981 - "To study adverse reactions associated with intravenous administration of fusidic acid 6 patients were treated with fusidic acid intravenously in association with a major large bowl operation, and 9 patients were treated in the same way because of staphylococcal infections. " 10/05/1969 - "[Clinical study of sodium fusidate in surgical staphylococcal infections]." 05/27/1967 - "[Bacteriological studies in the therapy of treatment-resistant staphylococcal infections with fusidic acid]." 05/01/2015 - "Fusidic acid is a topical and systemic antimicrobial used for the treatment of staphylococcal infections in hospitals and the community. " 01/01/2012 - "Fusidic acid is a common therapy for staphylococcal infections in Saudi Arabia, but reports have suggested high rates of resistance among clinical isolates. "
4.	Bacterial Conjunctivitis 08/01/1995 - "Topical fusidic acid may not be optimal empiric therapy of bacterial conjunctivitis." 08/01/1999 - "Topical fusidic acid gel is also effective in bacterial conjunctivitis and other minor external eye infections, and may be effective in reducing bacterial flora in the conjunctival sac prior to eye surgery. " 06/01/2002 - "The clinical and bacteriologic efficacy of fusidic acid viscous drops combined with the convenience of a twice-daily dosage regimen establishes this antibiotic as first-line treatment for suspected acute bacterial conjunctivitis and a favourable alternative to other broad-spectrum antibiotics." 06/01/2002 - "Treatment of acute bacterial conjunctivitis: 1% fusidic acid viscous drops vs. 0.3% tobramycin drops." 01/01/1987 - "The overall clinical success rate in children with bacterial conjunctivitis was 85% with fusidic acid, compared to 48% with chloramphenicol (p less than 0.001). "
5.	Erythrasma 11/01/1971 - "Sodium fusidate in the treatment of erythrasma." 02/01/2013 - "Topical fusidic acid proved to be the most effective treatment; however, clarithromycin therapy may be an alternative regimen in the treatment of erythrasma because of its efficiency and better patient's compliance." 08/01/1999 - "Studies with topical fusidic acid have also been reported in specific disease states such as acne, erythrasma, and abscesses with good results." 02/01/2013 - "To compare the efficacy of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma in a double-blind, placebo-controlled, randomized trial. " 03/01/1991 - "In a Danish multi-practice study the efficacy of erythromycin tablets (Abboticin 500 mg tablets), fusidic acid cream (Fucidin cream), and placebo was compared in 86 patients (71 men and 15 women) with erythrasma. "

Related Drugs and Biologics

1.	Rifampin (Rifampicin)
2.	Fusidic Acid (Fucithalmic)
3.	Vancomycin
4.	Teicoplanin
5.	Mupirocin (Bactroban)
6.	Anti-Bacterial Agents (Antibiotics)
7.	Erythromycin (Erycette)
8.	Fluoroquinolones
9.	linezolid (Zyvox)
10.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Catheters
3.	Transplantation (Transplant Recipients)
4.	Microspheres (Microsphere)
5.	Arthroplasty