Follicle Stimulating Hormone (Follitropin)

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.

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Networked: 1908 relevant articles (29 outcomes, 154 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sairam, M Ram: 10 articles (01/2012 - 10/2003)
2.	Sammel, Mary D: 9 articles (06/2015 - 04/2006)
3.	Check, J H: 9 articles (04/2014 - 01/2004)
4.	Fauser, Bart C J M: 8 articles (04/2011 - 01/2002)
5.	Freeman, Ellen W: 7 articles (09/2014 - 04/2006)
6.	Schlegel, Peter N: 6 articles (01/2014 - 08/2007)
7.	Hall, Janet E: 6 articles (04/2012 - 07/2004)
8.	Malcom, Pamela J: 6 articles (05/2008 - 04/2003)
9.	Chang, R Jeffrey: 6 articles (05/2008 - 04/2003)
10.	Feng, Youji: 5 articles (06/2015 - 07/2008)

Related Diseases

1.	Infertility (Sterility) 06/01/2011 - "The availability of an improved injection device for the delivery of follitropin α used during infertility treatment cycles of ovulation induction and assisted reproductive technology offers patients and healthcare professionals new treatment administration options. " 02/01/1999 - "The present study was designed to compare the clinical efficacy of low-dose step-up follicle stimulating hormone (FSH) administration with conventional FSH protocol (FSH was injected daily starting with a dose of 150 IU), both combined with intrauterine insemination (IUI), for the treatment of unexplained infertility. " 02/01/1999 - "The clinical efficacy of low-dose step-up follicle stimulating hormone administration for treatment of unexplained infertility." 01/01/2011 - "In this market research study with infertile patients and infertility nurses, the redesigned follitropin alfa pen was perceived as easy to learn, easy to teach how to use, and well accepted." 01/01/2011 - "A redesigned follitropin alfa pen injector for infertility: results of a market research study."
2.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/01/2015 - "Outcomes of follicle-stimulating hormone priming and nonpriming in in vitro maturation of oocytes in infertile women with polycystic ovarian syndrome: a single-blinded randomized study." 11/01/2010 - "Prospective, randomized study comparing highly purified urinary follicle-stimulating hormone (FSH) and recombinant FSH for in vitro fertilization/intracytoplasmic sperm injection in patients with polycystic ovary syndrome." 10/01/1996 - "The importance of endogenous feedback for monofollicular growth in low-dose step-up ovulation induction with follicle-stimulating hormone in polycystic ovary syndrome: a randomized study." 05/01/2015 - "The success rate was 49.18% for lowering elevated levels of follicle stimulating hormone (FSH), with a 39.34% pregnancy rate in that group, and 53.57% of the women with polycystic ovarian syndrome (PCOS) achieved pregnancy. " 11/01/2012 - "Sequential low-dose step-up and step-down protocols with recombinant follicle-stimulating hormone in polycystic ovary syndrome: prospective comparison with step-down protocol."
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2012 - "Investigative clinical study on prostate cancer part VI: Follicle-stimulating hormone and the pituitary-testicular-prostate axis at the time of initial diagnosis and subsequent cluster selection of the patient population." 03/01/1999 - "This study was conducted to characterize the expression of the receptor (FSHR) for follicle-stimulating hormone (FSH) in androgen-independent prostate cancer cell lines and in human malignant prostate tissues. " 03/01/2015 - "Emerging evidence has postulated that follicle-stimulating hormone (FSH) may lead to proliferative and mutagenic responses of prostate cancer. " 01/01/2013 - "Serum level of follicle-stimulating hormone is associated with extraprostatic extension of prostate cancer." 01/01/2012 - "To evaluate the physiopathology of follicle-stimulating hormone (FSH) along the pituitary-testicular-prostate axis at the time of initial diagnosis of prostate cancer in relation to the available clinical variables and to the subsequent cluster selection of the patient population. "
4.	Body Weight (Weight, Body) 09/01/2014 - "An experiment was conducted to evaluate the efficacy of porcine follicle stimulating hormone (pFSH) dosage based on body weight (BW) on ovarian responses of crossbred does. " 03/01/2015 - "Frequency of sexual intercourse (P = .046), sexual desire (P = .002), body weight (P = .009) and serum follicle stimulating hormone (FSH) level (P = .016) decreased significantly at the end of month of Ramadan compared to baseline. " 09/01/2014 - "Follicle Stimulating Hormone (FSH) Dosage Based on Body Weight Enhances Ovulatory Responses and Subsequent Embryo Production in Goats." 08/01/2004 - "However, no significant change was noted in final body weight, spermatogonia-A and plasma level of follicle stimulating hormone. " 11/01/2000 - "Body weight, height, SpO(2), hematocrit, serum follicle stimulating hormone (FSH), T and E(2) levels were measured in all women. "
5.	Varicocele 04/01/2015 - "Significant improvement in the mean sperm concentration, total motility, and lower follicle-stimulating hormone levels was noted in those who underwent varicocele embolization as compared with those not treated. " 02/01/2013 - "In men with lower preoperative follicle-stimulating hormone, larger testicular volume, a varicocele history and hypospermatogenesis on preoperative or intraoperative diagnostic biopsy there was a greater chance of finding sperm in the initial wide incision alone (p <0.05). " 06/01/1986 - "An equal number of infertile controls without varicoceles were matched for characteristics such as left testicular size, serum follicle-stimulating hormone levels, and sperm concentration to ensure similar degrees of testicular dysfunction. " 06/01/2006 - "One hundred twenty male cases subdivided into six equal groups were consecutively included; fertile normozoospermic men, oligoasthenozoospermia (OA), OA with leucocytospermia, OA with varicocele, non-obstructive azoospermia (NOA) with high serum follicle stimulating hormone (FSH) and NOA with normal FSH. " 08/01/2004 - "The patients with low grade varicocele, high serum follicle stimulating hormone (FSH), severe asthenozoospermia preoperatively had significant lower unassisted pregnancy rates compared to the others, respectively. "

Related Drugs and Biologics

1.	Luteinizing Hormone (Lutropin)
2.	Testosterone (Sustanon)
3.	Gonadotropin-Releasing Hormone (GnRH)
4.	Estradiol (Estrace)
5.	Hormones
6.	Gonadotropins
7.	Prolactin
8.	Clomiphene (Clomifene)
9.	abarelix (Plenaxis)
10.	Progesterone

Related Therapies and Procedures

1.	Orchiectomy (Orchidectomy)
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Drug Therapy (Chemotherapy)
4.	Hysterectomy
5.	Intravenous Injections