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Fructose-Bisphosphate Aldolase (Aldolase)

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An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13.

Also Known As:

Aldolase; Aldolase A; Aldolase B; Fructose 1 Phosphate Aldolase; Aldolase C; Fructose 1,6-Bisphosphate Aldolase; Fructose 1,6-Bisphosphate Aldolase, Class II; Fructose 1-Phosphate Aldolase; Fructose Biphosphate Aldolase; Fructosemonophosphate Aldolase; 1,6-Bisphosphate Aldolase, Fructose; Aldolase, Fructose 1,6-Bisphosphate; Aldolase, Fructose 1-Phosphate; Aldolase, Fructose Biphosphate; Aldolase, Fructose-Bisphosphate; Aldolase, Fructosediphosphate; Aldolase, Fructosemonophosphate; Fructose 1,6 Bisphosphate Aldolase; Fructose Bisphosphate Aldolase; Fructosediphosphate Aldolase; D-Fructose-1,6-biphosphate D-glyceraldehyde-3-phosphate-lyase

Networked: 921 relevant articles (5 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Lyases: 25
    - Carbon-Carbon Lyases
      - Aldehyde-Lyases: 28
        Fructose-Bisphosphate Aldolase: 921
        antibody aldolase
        bacteria FucA protein
        citraconyl-aldolase
        E coli fucA protein

Experts

1.	Tolan, Dean R: 9 articles (03/2015 - 12/2002)
2.	Zagari, Adriana: 4 articles (12/2010 - 11/2002)
3.	Salvatore, Francesco: 4 articles (12/2010 - 11/2002)
4.	Esposito, Gabriella: 4 articles (12/2010 - 11/2002)
5.	Vitagliano, Luigi: 4 articles (12/2010 - 11/2002)
6.	Nussenzweig, Victor: 3 articles (01/2015 - 02/2007)
7.	Buscaglia, Carlos A: 3 articles (01/2015 - 02/2007)
8.	Lerner, Richard A: 3 articles (02/2013 - 03/2004)
9.	Sinha, Subhash C: 3 articles (02/2013 - 03/2004)
10.	Allen, Karen N: 3 articles (05/2008 - 03/2005)

Related Diseases

1.	Malaria 09/01/2013 - "The Malaria Pf Rapid Test Device Acon® (Acon Labs) and the pan HRP2/aldolase RDT, Malaria P.f/Pan Rapid Test Device Acon® (Acon Labs), performances were evaluated for malaria species diagnosis in 592 febrile patients living in Gabon using microscopy as gold standard. " 01/01/2014 - "In order to identify a quick and reliable technique for accurate diagnosis of malaria, study of the efficiency of the tests such as Parahit total (HRPII & aldolase Ag), Advantage mal card (parasite specific LDH), and modified QBC was done in comparison with conventional blood smear microscopy. " 01/01/2013 - "This study further elucidates the possibility of developing aldolase-specific RDTs which can differentiate the different Plasmodium infections and improve accurate diagnosis of malaria. " 01/01/2014 - "vivax-positive samples (n = 77) that were confirmed by microscopic examination as well as the two aldolase detection RDTs (mAb 1C3-12 F10 and ParaHit Total ver.1.0) were undetected by the two LDH detection RDTs (One Step Malaria P.f/P.v and SD Bioline). " 10/01/2013 - "This paper describes recent developments in malaria RDTs, reviewing RDTs detecting PfHRP2, pLDH and plasmodial aldolase. "
2.	Neoplasms (Cancer) 01/01/1988 - "The study of the expression of aldolase A gene in normal liver and neoplastic cell lines demonstrated the resurgence of foetal pattern of expression in all tumor liver cell lines and HeLa cells, thus supporting the foetalism theory for this gene system." 07/01/1979 - "[Clinical study on aldolase isoenzyme--the development of the method of cancer diagnosis with muscle type aldolase (author's transl)]." 02/04/2013 - "Integrin α5β1 is an important therapeutic target that can be inhibited using an aldolase antibody (Ab)-derived chemical-Ab (chem-Ab) for the treatment of multiple human diseases, including cancers. " 02/15/2004 - "We identified 4 genes, the expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues. " 11/01/2001 - "Aldolase becomes elevated in serum with malignant tumors, and isozyme A is predominant in serum. "
3.	Shock 08/10/1976 - "[Changes of aldolase activity in shock patients]." 12/01/1983 - "[Serum CPK and aldolase activities in rabbits with tourniquet shock]." 09/30/1963 - "[ALDOLASE IN THE BLOOD AFTER INTRAVENOUS INJECTION OF POST-SHOCK CEREBROSPINAL FLUID]." 07/01/2012 - "Two of them (42 and 36 kDa) were found to be regulated by heat shock and by nutritional stress and they were identified as phosphoglycerate kinase and fructose bisphosphate aldolase, respectively. " 02/01/1983 - "In muscle from a sensitive pig which died of heat shock under anaesthesia there was a selective loss of glyceraldehyde-3-phosphate dehydrogenase and aldolase, presumably owing to proteolytic activity. "
4.	Schistosomiasis (Bilharziasis) 10/01/2011 - "japonicum fructose-1, 6-bisphosphate aldolase (rSjFBPA), and evaluate the potential of rSjLAP and rSjFBPA in diagnosis as well as in assessment of therapeutic efficacy in human schistosomiasis. " 09/01/2009 - "Diagnosis of schistosomiasis using recombinant fructose-1,6-bisphosphate aldolase from a Formosan strain of Schistosoma japonicum." 09/01/2009 - "Recombinant fructose-1,6-bisphosphate aldolase (FBPA) derived from this strain was used as an antigen in an enzyme-linked immunosorbent assay (ELISA) for the diagnosis of human schistosomiasis. "
5.	Muscular Diseases (Myopathy) 11/01/1983 - "[Studies on the serum aldolase activity in workers with muscle disorders caused by vibration work]." 01/01/1967 - "Study of serum aldolase in neuro-muscular diseases." 01/01/1964 - "[STUDY OF SERUM ALDOLASE IN MUSCULAR DISEASES]." 01/01/1960 - "[Study of serum transaminase and aldolase levels in the course of myopathy]." 08/01/2009 - "In patients with muscle discomfort or mild weakness and a normal CK, measurement of serum aldolase can be useful in the evaluation of possible myopathies."

Related Drugs and Biologics

1.	Enzymes
2.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
3.	Antigens
4.	Messenger RNA (mRNA)
5.	Histidine (L-Histidine)
6.	Phosphopyruvate Hydratase (Enolase)
7.	Triose-Phosphate Isomerase (Triosephosphate Isomerase)
8.	Complementary DNA (cDNA)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Interferons

Related Therapies and Procedures

1.	Radiotherapy
2.	Homologous Transplantation (Allograft)
3.	Transplantation (Transplant Recipients)
4.	Tourniquets
5.	Intravenous Injections