Colforsin

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

Also Known As:

Networked: 1178 relevant articles (38 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Beekman, Jeffrey M: 7 articles (01/2022 - 07/2013)
2.	Villamor, Eduardo: 6 articles (11/2017 - 09/2004)
3.	van der Ent, Cornelis K: 5 articles (01/2022 - 07/2013)
4.	Wallace, Darren P: 5 articles (01/2018 - 12/2006)
5.	Kruisselbrink, Evelien: 4 articles (01/2022 - 01/2018)
6.	Vonk, Annelotte M: 4 articles (01/2022 - 11/2017)
7.	de Winter-de Groot, Karin M: 4 articles (01/2022 - 07/2013)
8.	Clevers, Hans: 4 articles (01/2020 - 07/2013)
9.	Dekkers, Johanna F: 4 articles (01/2020 - 07/2013)
10.	Calvet, James P: 4 articles (01/2018 - 12/2006)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2023 - "As a natural cAMP elevating agent, Forskolin has shown anti-cancer properties in different tumor types, thus supposing its possible usage in treating malignancies. " 01/01/2017 - "Among forskolin derivatives, compounds 11a, 11c, 14a, 14f, 14g, 14h, 15b, 16g and 17b exhibited higher anti-cancer activity against MCF-7 cell line with an IC50≤1µM. " 11/01/2013 - "Subsequently, two steroidogenic cell lines (Y-1 mouse adrenal tumor and MA-10 mouse Leydig tumor cells) were used in a reverse transcription-PCR analysis to assess the effects of all compounds on steroidogenic gene expressions using forskolin as a positive control. " 01/01/2013 - "Importantly, the cytotoxic effect of the inhibitors on cancer cells is strongly enhanced by forskolin, a PKA pathway activator, that we have previously shown to stimulate OXPHOS. " 05/01/2011 - "in direct contact to a living tissue, forskolin-induced differentiation of BeWo cells leads to an increase in tumor formation in the CAM. "
2.	Asthma (Bronchial Asthma) 02/01/1998 - "Thus, the combination of forskolin and PDE inhibitors would become useful in the treatment of bronchial asthma." 03/01/2006 - "To determine the efficacy of forskolin in preventing asthma attacks, we performed a single-blinded clinical study in children and adult out-patients at a public hospital in Mexico. " 03/01/2010 - "More studies are needed in adult asthma patients to confirm whether forskolin may be a useful preventive treatment for mild or moderately persistent adult asthma." 03/01/2020 - "forskohlii is forskolin, which is used commercially for the treatment of glaucoma, asthma and several heart ailments. " 03/01/2006 - "We conclude that forskolin is more effective than sod cromoglycate in preventing asthma attacks in patients with mild persistent or moderate persistent asthma."
3.	Ischemia 05/01/1996 - "However, the percentage increase in forskolin-pretreated preconditioned hearts during sustained ischemia was only 50% vs. 71% in non-preconditioned hearts treated with forskolin, confirming an attenuated beta-response induced by preconditioning. " 01/01/1996 - "NKH477 (45 micrograms/kg) increased average cAMP levels in IP hearts during sustained ischemia to levels similar to those in untreated control hearts. " 11/01/1992 - "On the contrary, in the exo-focal remote areas, there was no alteration of either [3H]forskolin or D-1 receptor binding sites on day 1. However, 3 days after the ischemia, marked reduction of both these binding sites was first observed in the ipsilateral substantia nigra, which had not been directly affected by the original ischemic insult. " 11/01/1991 - "[3H]Forskolin binding sites were found to be markedly decreased in the lateral segment of the caudate putamen supplied by the occluded MCA after 90 min of ischemia with no recirculation. " 04/05/1991 - "In the dentate gyrus, the structure of which remained histologically intact after ischemic insult, [3H]IP3 and [3H]forskolin binding activities decreased 7 days after ischemia. "
4.	Hypertension (High Blood Pressure) 01/01/2014 - "These characteristics have made forskolin an effective medication for heart disease, hypertension, diabetes, and asthma. " 01/01/2015 - "Forskolin is used in the treatment of hypertension, congestive heart failure, eczema, and other diseases. " 03/01/1983 - "On the other hand, hearts from two-kidney, one clip renal hypertensive rats 6 weeks after initiation of hypertension showed decreased basal, ISO, NaF, and GTP analog-stimulated cyclase activity with no change in Mn++ or forskolin-stimulated activity. " 08/01/1999 - "Since forskolin bypasses the beta-receptor to directly stimulate adenylate cyclase, these results suggest that obesity-hypertension is associated with a defect in post-beta-receptor signaling pathways." 11/01/1999 - "In contrast, GTPgammas and forskolin stimulated cAMP generation to a similar degree in both rat strains, which suggests normal adenylate cyclase activity in hypertension-prone SHR. "
5.	Autosomal Dominant Polycystic Kidney (ADPKD) 10/01/1996 - "Using monolayers of cultured ADPKD cells, grown on permeant supports, we compared the changes in short circuit current (ISC) induced by forskolin in the presence and absence of external Cl-. " 09/01/1995 - "Forskolin increased the transepithelial potential difference (Vte) of ADPKD monolayers (-0.9 +/- 0.1 to -1.1 +/- 0.1 mV) and the short-circuit current (Isc) (6.6 +/- 0.7 to 9.2 +/- 0.8 microA/cm2). " 01/01/2021 - "HC and ADPKD organoids did not spontaneously form cysts, but upon forskolin stimulation, cysts-like structures were observed in the ADPKD organoids but not in the HC-derived organoids. " 01/01/1995 - "We measured the net transepithelial movement of liquid in response to forskolin in isolated, intact cysts excised from the surface of human ADPKD kidneys and in cultured, polarized monolayers of epithelial cells derived from ADPKD cysts. " 10/01/2022 - "H2-GMZ was effective in rapidly blocking forskolin-induced, Cl--mediated short-circuit currents in human ADPKD cells, and it significantly inhibited both cAMP- and epidermal growth factor-induced proliferation of ADPKD cells. "

Related Drugs and Biologics

1.	Adenylyl Cyclases (Adenylyl Cyclase)
2.	Cyclic AMP (AMP, Cyclic)
3.	Colforsin
4.	Isoproterenol (Isoprenaline)
5.	Vitamins
6.	Tretinoin (Retinoic Acid)
7.	Opioid Analgesics (Opioids)
8.	Messenger RNA (mRNA)
9.	Adenosine (Adenocard)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Low-Level Light Therapy (LLLT)
4.	Traditional Medicine (Folk Remedies)
5.	Intraventricular Injections