Formate Dehydrogenases

Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds can act as acceptors, but the only physiologically active acceptor is NAD. The enzymes are active in the fermentation of sugars and other compounds to carbon dioxide and are the key enzymes in obtaining energy when bacteria are grown on formate as the main carbon source. They have been purified from bovine blood. EC 1.2.1.2.

Also Known As:

NAD-Formate Dehydrogenase; Dehydrogenase, Formate; Dehydrogenase, NAD-Formate; Dehydrogenases, Formate; Hydrogenlyases, Formate; NAD Formate Dehydrogenase; Formate Dehydrogenase; Formate Hydrogenlyases; Formate:NAD+ oxidoreductase

Networked: 14 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on Aldehyde or Oxo Group Donors
      - Formate Dehydrogenases: 14
        formate hydrogenlyase: 2
        formate dehydrogenase-O: 1
        Candida FDH1 protein
        Formate dehydrogenase (cytochrome)
        formate dehydrogenase (NADP+)
        S cerevisiae FDH1 protein

Experts

1.	Muthuvel, Arumugham: 2 articles (05/2006 - 02/2006)
2.	Rajamani, Rathinam: 2 articles (05/2006 - 02/2006)
3.	Sheeladevi, Rathinasamy: 2 articles (05/2006 - 02/2006)
4.	Kaundal, Amita: 1 article (01/2022)
5.	Kwon, Taegun: 1 article (01/2022)
6.	Lee, Hee-Kyung: 1 article (01/2022)
7.	Lee, Seonghee: 1 article (01/2022)
8.	Mysore, Kirankumar S: 1 article (01/2022)
9.	Oh, Sunhee: 1 article (01/2022)
10.	Oh, Youngjae: 1 article (01/2022)

Related Diseases

1.	Poisoning 02/20/2006 - "Results obtained show that there is significant elimination of formate within 15 min. It may be concluded that single bolus infusion of formate dehydrogenase facilitates fast removal of formate, a highly toxic metabolite in methanol poisoning." 12/01/2006 - "Single bolus intravenous infusion of native formate dehydrogenase (FD), isolated from Candida boidinii was found to eliminate formate, a highly toxic metabolite in methanol poisoning. " 12/01/2006 - "Modification of allergenicity and immunogenicity of formate dehydrogenase by conjugation with linear mono methoxy poly ethylene glycol: improvement in detoxification of formate in methanol poisoning." 05/01/2006 - "Formate dehydrogenase-loaded erythrocytes, along with carbicarb, facilitates removal of formate, in methanol poisoning."
2.	Disease Resistance 01/01/2022 - "Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens." 01/01/2022 - "In the present study, the metabolic enzyme formate dehydrogenase 1 (FDH1) was identified to associate with nonhost disease resistance in Nicotiana benthamiana and Arabidopsis thaliana. " 01/01/2019 - "Pepper formate dehydrogenase 1 (FDH1), which is required for R-gene-mediated disease resistance, may be regulated by nat-siRNAs and participate in a positive feedback loop in salicylic acid biosynthesis during resistance responses. "
3.	Colitis 02/08/2017 - "Complementary studies using commensal E. coli strains as model organisms indicated that formate dehydrogenase and terminal oxidase genes provided a fitness advantage in murine models of colitis. "
4.	Infections 01/01/2016 - "Our results demonstrate that formate dehydrogenase and calreticulin-3 precursor are required for CMV-P1 infection. " 01/01/2016 - "Formate dehydrogenase-silenced plants showed local infection in inoculated leaves, but not in upper (systemic) leaves. " 08/01/2012 - "FdhTU-modulated formate dehydrogenase expression and electron donor availability enhance recovery of Campylobacter jejuni following host cell infection." 08/01/2011 - "It is suspected that the expression of the formate dehydrogenase gene is directly controlled by the pathogen in the early stage of infection, and additionally by pectin degradation in the later stages."
5.	Starvation 04/01/2013 - "Using microarray analysis, we found that the expression of genes encoding coenzyme F420-dependent steps of methanogenesis, including one of two formate dehydrogenases, increased with H2 starvation but with formate occurred at high levels regardless of limitation or excess. " 08/01/1988 - "The results indicated an inverse relationship between the amount of transcript and the amount of formate dehydrogenase protein detected in response to molybdenum starvation. "

Related Drugs and Biologics

1.	formic acid (formate)
2.	Methanol (Carbinol)
3.	Ethylene Glycol (Monoethylene Glycol)
4.	Enzymes
5.	Oxidoreductases (Dehydrogenase)
6.	Salicylic Acid (2 Hydroxybenzoic Acid)
7.	2,6-Dichloroindophenol (2,6 Dichloroindophenol)
8.	Proteins (Proteins, Gene)
9.	Pectins
10.	Paraquat

Related Therapies and Procedures

1.	Intravenous Infusions