Arylformamidase

An enzyme that catalyzes the conversion of N-formyl-L-kynurenine and water to formate and L-kynurenine. It also acts on other aromatic formylamines. (Enzyme Nomenclature, 1992) EC 3.5.1.9.

Also Known As:

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Seifert, Josef: 3 articles (10/2017 - 03/2013)
2.	Boos, Drake: 1 article (11/2022)
3.	Chuang, Tsai-Der: 1 article (11/2022)
4.	Khorram, Omid: 1 article (11/2022)
5.	Quintanilla, Derek: 1 article (11/2022)
6.	Bentley, Liz: 1 article (10/2015)
7.	Cox, I Jane: 1 article (10/2015)
8.	Cox, Roger D: 1 article (10/2015)
9.	Hough, Tertius A: 1 article (10/2015)
10.	Hugill, Alison J: 1 article (10/2015)

Related Diseases

1.	Teratogenesis 10/01/1982 - "This equivalence does not support the proposition that the inhibition of kynurenine formamidase causes the lowered NAD+ levels involved in OP-induced type I teratogenesis. " 03/01/2013 - "Structural requirements of organophosphorus insecticides (OPI) to inhibit chicken yolk sac membrane kynurenine formamidase related to OPI teratogenesis." 05/01/2016 - "The objective of this study was to determine the structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo nicotinamide adenine dinucleotide (NAD(+)) content in OPI-induced teratogenesis and compare them with those needed for OPI inhibition of yolk sac membrane kynurenine formamidase (KFase), the proposed primary target for OPI teratogens in chicken embryos. " 10/01/2017 - "Embryo yolk sac membrane kynurenine formamidase of l-tryptophan to NAD+ pathway as a primary target for organophosphorus insecticides (OPI) in OPI-induced NAD-associated avian teratogenesis." 10/01/2017 - "The objective of this study was to provide in ovo evidence for the proposed role of kynurenine formamidase of l-tryptophan to NAD+ pathway in embryo yolk sac membranes as a primary target for organophosphorus insecticide (OPI) teratogens in OPI-induced NAD-associated avian teratogenesis. "
2.	Renal Insufficiency (Renal Failure) 10/02/2015 - "A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a double knockout of this gene and thymidine kinase (Tk) has been reported to cause renal failure and abnormal immune system regulation. "
3.	Glucose Intolerance 10/02/2015 - "Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance."
4.	Leiomyoma (Uterine Fibroids) 11/01/2022 - "In fibroids, the expression of tryptophan hydroxylase 1 (TPH1), kynurenine amino transferase (KAT)2, large neutral amino acid transporter small subunit 2 (SLC7A8), and large neutral amino acid transporter small subunit 1 (SLC7A5) messenger RNA (mRNA) was high and that of kynureninase (KYNU) and tryptophanyl-tRNA ligase (WARS1) mRNA was low, with no changes in the expression of WARS2, kynurenine formamidase (AFMID), kynurenine 3-monooxygenase (KMO), KAT1, KAT3, and KAT4 compared with that in the matched myometrium (n = 81). "

Related Drugs and Biologics

1.	Insecticides
2.	Teratogens
3.	NAD (NADH)
4.	Tryptophan (L-Tryptophan)
5.	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)
6.	Large Neutral Amino Acid-Transporter 1
7.	Amino Acid Transport Systems (Amino Acid Transporter)
8.	Tryptophan Hydroxylase
9.	Transferases
10.	Thymidine Kinase