Foot Rot

A disease of the horny parts and of the adjacent soft structures of the feet of cattle, swine, and sheep. It is usually caused by Corynebacterium pyogenes or Bacteroides nodosus (see DICHELOBACTER NODOSUS). It is also known as interdigital necrobacillosis. (From Black's Veterinary Dictionary, 18th ed)

Also Known As:

Networked: 61 relevant articles (8 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Cellulitis
3.	Pneumonia (Pneumonitis)
4.	Pain (Aches)
5.	Mastitis

Experts

1.	Sun, Dongbo: 1 article (12/2013)
2.	Li, Chunqiu: 1 article (12/2013)
3.	Zhang, Hong: 1 article (12/2013)
4.	Guo, Donghua: 1 article (12/2013)
5.	Vorachek, William R: 1 article (01/2013)
6.	Hugejiletu,: 1 article (01/2013)
7.	Bobe, Gerd: 1 article (01/2013)
8.	Hall, Jean A: 1 article (01/2013)
9.	Parthasarathy, V A: 1 article (07/2009)
10.	Johnson George, K: 1 article (07/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Foot Rot:

1.	Oxytetracycline (Terramycin)FDA Link 08/01/1981 - "A test was designed to evaluate the efficacy of a new oxytetracycline aerosol in the treatment of foot rot in sheep. " 08/01/1981 - "Efficacy of a new oxytetracycline aerosol against foot rot in sheep." 01/01/2003 - "Two clinical trials evaluated the efficacy of ceftiofur sodium versus placebo for naturally occurring foot rot, and two trials compared the efficacy of ceftiofur sodium or hydrochloride (1.0 mg CE/kg) with oxytetracycline (6.6 or 10 mg/kg), each administered once daily for 3 days, for treatment of acute foot rot in beef cattle. " 01/15/1998 - "Comparison of ceftiofur sodium and oxytetracycline for treatment of acute interdigital phlegmon (foot rot) in feedlot cattle."
2.	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 11/01/1984 - "The efficacy of an ethylenediamine dihydriodide containing salt mixture was evaluated with regard to the prevention of naturally occurring foot rot in pastured cattle. " 11/01/1984 - "Efficacy of ethylenediamine dihydriodide in the prevention of naturally occurring foot rot in cattle." 06/01/1984 - "Efficacy of ethylenediamine dihydriodide as an agent to prevent experimentally induced bovine foot rot." 05/01/1976 - "The addition of ethylenediamine dihydriodide or urea to the rations did not affect the frequency of experimentally induced foot rot." 05/01/1976 - "Experimentally induced foot rot in feedlot cattle fed rations containing organic iodine (ethylenediamine dihydriodide) and urea."
3.	ceftiofurIBA 01/01/2003 - "Seven well-controlled studies conducted under multiple management conditions demonstrated that ceftiofur, a late-generation veterinary parenteral cephalosporin, is effective for the treatment of bovine foot rot in beef and dairy cattle. " 01/01/2003 - "All trials demonstrated the efficacy of ceftiofur for treatment of acute bovine foot rot. " 01/01/2003 - "A comprehensive review of ceftiofur sodium and hydrochloride formulations for treatment of acute bovine foot rot." 07/01/2002 - "Ceftiofur has worldwide approvals for respiratory disease in swine, ruminants (cattle, sheep and goats) and horses and has also been approved for foot rot and metritis infections in cattle. " 01/15/1998 - "To determine whether ceftiofur sodium would be useful for treatment of acute interdigital phlegmon (foot rot) in cattle. "
4.	Formaldehyde (Formol)FDA Link 09/01/1982 - "Most chemicals tested had penetration rates of less than 0.1 mm per hour and formalin, a chemical widely used for treatment of foot rot, penetrated very poorly (less than 0.02 mm per hour). " 06/17/1972 - "Corono-pedal abscessation following the excessive use of formalin as a treatment for foot-rot in sheep." 06/17/1972 - "The potential danger arising from the misuse of formalin in the treatment of foot-rot in sheep." 09/01/1989 - "A comparison was made of the efficacy of zinc sulphate and formalin footbaths in treating foot-rot of a wide range of severity in a British lowland sheep flock. " 09/01/1989 - "A comparison of the efficacy of footbaths containing formalin or zinc sulphate in treating ovine foot-rot under field conditions."
5.	IodineIBA 10/01/1989 - "A rate of 0.11 mg EDDI/kg/day was correlated with serum iodine concentrations (20 to 80 micrograms/dl) previously found to be effective in preventing foot rot in cattle. " 05/01/1976 - "Experimentally induced foot rot in feedlot cattle fed rations containing organic iodine (ethylenediamine dihydriodide) and urea."
6.	ZincIBA 09/01/1989 - "A comparison was made of the efficacy of zinc sulphate and formalin footbaths in treating foot-rot of a wide range of severity in a British lowland sheep flock. " 09/01/1989 - "A comparison of the efficacy of footbaths containing formalin or zinc sulphate in treating ovine foot-rot under field conditions."
7.	Amoxicillin (Wymox)FDA LinkGeneric 12/01/1987 - "Efficacy of amoxicillin trihydrate for the treatment of experimentally induced foot rot in cattle." 12/01/1987 - "It was concluded that administration of amoxicillin trihydrate early in the course of acute foot rot may reduce the severity of lesions associated with foot rot in cattle."
8.	Essential Amino AcidsIBA 01/01/2000 - "The application and future prospects of transformation technology to engineer the resistance against insect pests (stem borer, leaf folder, brown plant hopper, gall midge), fungal diseases (blast, bakanae/foot, rot), bacterial diseases (bacterial leaf blight, sheath blight), abiotic stresses (salinity and drought) and improved nutritional quality (accumulation of provitamin A and essential amino acids in endosperm) in Basmati rice, have been addressed."
9.	VaccinesIBA 02/01/1999 - "A higher and more specific immune response is observed when monovalent vaccines are used to treat foot rot, as compared to multivalent vaccines, which incorporate all 10 major New Zealand D. " 05/01/1992 - "These results suggest that low bodyweight due to poor nutrition is unlikely to affect the response of sheep to multivalent foot rot vaccines." 07/01/1988 - "Antibody responses of sheep vaccinated with foot rot vaccines." 05/01/1985 - "The protection given by pilus and whole cell vaccines of Bacteroides nodosus strain 198 against ovine foot-rot induced by strains of different serogroups." 03/01/1982 - "There were statistically significant differences among the four vaccines in the mean numbers of feet per sheep which developed severe foot rot during 27 weeks of exposure. "
10.	aluminum sulfate (alum)IBA 12/01/1986 - "A commercial, polyvalent, alum-oil adjuvanted vaccine against foot-rot was tested under conditions where climatic and management circumstances have traditionally made foot-rot difficult to control or eradicate. " 04/01/1986 - "The effects of vaccination of Merino sheep with the purified pili or the whole cells of Bacteroides nodosus strain 198, either in oil or alum-oil adjuvant, on the severity of foot-rot induced with the homologous strain (198) and a heterologous strain (217) were determined in a field experiment, on flood irrigated pasture. " 01/01/1981 - "Foot rot in affected, vaccinated sheep was more severe in those which had received the alum precipitated vaccine than in those given the oil emulsion vaccine, but vaccinated sheep were always less severely affected than controls. " 01/01/1981 - "Comparison of alum-absorbed or non-alum-absorbed oil emulsion vaccines containing either pilate or non-pilate Bacteroides nodosus cells in inducing and maintaining resistance of sheep to experimental foot rot." 01/01/1981 - "Effect of alum-precipitated or oil-adjuvant Bacteroides nodosus vaccines on the resistance of sheep to experimental foot rot."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 06/01/1968 - "Parenteral chemotherapy of ovine foot-rot."
2.	Baths 08/15/1983 - "Of the chemicals commonly used in foot baths for treatment of ovine foot rot, copper sulfate was most effective, followed by zinc sulfate, then formalin. "
3.	Oral Administration 04/01/1981 - "Oral administration of zinc sulfate for control of ovine foot rot."