Folic Acid Deficiency (Folic Acid Deficiencies)

A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Also Known As:

Networked: 390 relevant articles (6 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Inflammation
3.	Atrophy
4.	Vitiligo
5.	Peripheral Nervous System Diseases (PNS Diseases)

Experts

1.	Wang, Yi-Ping: 4 articles (09/2015 - 04/2015)
2.	Cheng, Shih-Jung: 4 articles (09/2015 - 04/2015)
3.	Wu, Yang-Che: 4 articles (09/2015 - 04/2015)
4.	Chen, Hsin-Ming: 4 articles (09/2015 - 04/2015)
5.	Chang, Julia Yu-Fong: 4 articles (09/2015 - 04/2015)
6.	Sun, Andy: 4 articles (09/2015 - 04/2015)
7.	Fenech, Michael: 4 articles (01/2014 - 01/2004)
8.	Thomas, Philip: 3 articles (01/2014 - 01/2004)
9.	Mattson, Mark P: 3 articles (07/2005 - 03/2002)
10.	Wang, Jie: 2 articles (01/2015 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Folic Acid Deficiency:

1.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/01/2015 - "1. To study the prevalence of vitamin B12 and folic acid deficiency in the population of western Maharashtra. " 01/01/2015 - "This study summarizes the prevalence of vitamin B12 and folic acid deficiency in the population coming to tertiary care center in Western Maharashtra along with the main presenting symptom routinely misinterpreted in daily practice. " 01/01/2015 - "A study of the prevalence of serum vitamin B12 and folic Acid deficiency in Western maharashtra." 11/01/2014 - "Chile is the longest country in the world running perfectly North-South making it an ideal place to study potential associations of latitude and solar radiation on vitamin B12 and folic acid deficiency. " 11/01/2012 - "The aim of this study is to establish the prevalence of vitamin B12 and folic acid deficiency in the population of 65 years and over in semi-urban and rural area, as well as investigating the risk factors, and the determining factors of this deficiency in this population and its relationship with the prevalence of concomitant cardiovascular and cognitive diseases. "
2.	Folic Acid (Vitamin M)FDA LinkGeneric 11/01/1961 - "The plasma clearance of injected doses of folic acid as an index of folic acid deficiency." 09/01/2014 - "Despite of enormous importance of folic acid and the routine intake of bovine milk, folic acid deficiency diseases are common in human race. " 01/01/2012 - "Pregnant and lactating women are at increased risk of folic acid deficiency because generally their dietary folate is insufficient to meet their physiological requirements and the metabolic demands of the growing fetus. " 12/01/2010 - "Giving folic acid in the middle period, which is the early developmental stage, can best prevent the abnormal developments of hearts induced by folic acid deficiency. " 12/01/2010 - "To construct the folic acid deficient model in zebrafish and observe the abnormal cardiac phenotypes, to find the optimal period for supplementing folic acid that can most effectively prevent the heart malformation induced by folic acid deficiency, and to investigate the possible mechanisms by which folic acid deficiency induces malformations of heart. "
3.	IronIBA 01/01/2014 - "Other possible causes include iron, B12 or folic acid deficiency or blood loss. " 06/01/2005 - "Simultaneous iron and folic acid deficiencies affected 30.76% of anemic cases. " 06/01/2005 - "From anemic cases, 35.89% presented iron deficiency, while 91.02% presented folic acid deficiency. " 06/01/2005 - "Iron and folic acid deficiencies are the major causes of health problems among pregnant women and children, with a significant negative impact on economic and social development. " 09/01/2003 - "A low MCV correlated well with iron deficiency anaemia while a high MCV was associated with folic acid deficiency. "
4.	Hemoglobins (Hemoglobin)IBA 01/01/1953 - "[Study of some properties of hemoglobin in the syndrome of folic acid deficiency in the rat]." 10/07/2009 - "However, over the last 10 years a number of studies have been conducted and the most relevant conclusions obtained are: (1) anemia is quite common in IBD; (2) although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency; (3) anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patient; (4) oral iron can lead to gastrointestinal intolerance and failure of treatment; (5) intravenous iron is an effective and safe way to treat iron deficiency; (6) erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. " 04/01/2015 - "RAS patients had a significantly higher frequency of hemoglobin, iron, vitamin B12, or folic acid deficiency and of abnormally elevated blood homocysteine level than healthy control subjects (all P-values = 0.000 except for folic acid P = 0.022). " 06/01/2012 - "A number of studies have been conducted and the most relevant conclusions obtained are:(1)anemia is quite common in IBD; (2)although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency;(3)anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patients;(4)oral iron supplement is limited by poor absorption, intolerance, and induction of oxidative stress at the site of bowel inflammation; (5) intravenous iron sucrose has a high efficiency and a significant improvement in the quality of life; (6)erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. "
5.	ErythropoietinFDA Link 01/01/2006 - "Folic acid deficiency modifies the haematopoietic response to recombinant human erythropoietin in maintenance dialysis patients." 01/01/2000 - "Erythropoietin, folic acid deficiency and hyperhomocysteinemia: is there a possible relationship in chronically hemodialyzed patients?" 02/01/1990 - "Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness." 10/07/2009 - "However, over the last 10 years a number of studies have been conducted and the most relevant conclusions obtained are: (1) anemia is quite common in IBD; (2) although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency; (3) anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patient; (4) oral iron can lead to gastrointestinal intolerance and failure of treatment; (5) intravenous iron is an effective and safe way to treat iron deficiency; (6) erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. " 02/01/1990 - "Thirty six patients with rheumatoid arthritis (RA) (25 with anaemia) were studied to establish the role of iron, vitamin B12, and folic acid deficiency, erythropoietin responsiveness, and iron absorption in the diagnosis and pathogenesis of anaemia in RA. "
6.	saccharated ferric oxideFDA Link 06/01/2012 - "A number of studies have been conducted and the most relevant conclusions obtained are:(1)anemia is quite common in IBD; (2)although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency;(3)anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patients;(4)oral iron supplement is limited by poor absorption, intolerance, and induction of oxidative stress at the site of bowel inflammation; (5) intravenous iron sucrose has a high efficiency and a significant improvement in the quality of life; (6)erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. "
7.	VitaminsIBA 11/01/2000 - "Twenty-three percent of women had biochemical evidence of folic acid deficiency, 26% were deficient in vitamin B-6 and 10% had low vitamin B-12. " 03/01/1999 - "The brain is relatively resistant to folic acid deficiency, indicating specialized transport systems may exist for this vitamin localized within the brain capillary endothelial wall, which makes up the blood-brain barrier (BBB) in vivo. " 11/01/2006 - "There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, including the intimate relation between the metabolism of the two vitamins, their morphologically indistinguishable megaloblastic anaemias, and their overlapping neuropsychiatric syndromes and neuropathology, including their related inborn errors of metabolism. " 07/01/1993 - "The clear demonstration that periconceptional vitamin supplementation can dramatically reduce the recurrence rate of neural tube defects suggests that folic acid deficiency may be common even in otherwise well-nourished women. " 10/01/2015 - "Environmental factors such as maternal hormonal disorders, use of psychiatric medications, vitamin and folic acid deficiency, hypoxia, cigarette smoking and maternal obesity and overweight can affect the incidence of these disorders. "
8.	Phenytoin (Dilantin)FDA LinkGeneric 09/01/1999 - "A case of a patient who developed symptomatic phenytoin-induced folic acid deficiency is reported. " 05/01/1975 - "In vivo, the presence of immunological defects was not related to phenytoin-induced folic acid deficiency. " 06/30/1973 - "[Phenytoin-induced folic acid deficiency]." 01/01/1969 - "Dilantin and folic acid deficiency." 02/01/2002 - "Aplastic anemia induced by phenytoin: a geriatric case with severe folic acid deficiency."
9.	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 02/01/2010 - "Folic acid supplementation in patients with folic acid deficiency has been associated with increased clearance of phenytoin to its cytochrome P450 (CYP) 2C9-mediated metabolite, 5-(4'-hydroxyphenyl)-5-phenylhydantoin. "
10.	hydroxyphenytoinIBA 02/01/2010 - "Folic acid supplementation in patients with folic acid deficiency has been associated with increased clearance of phenytoin to its cytochrome P450 (CYP) 2C9-mediated metabolite, 5-(4'-hydroxyphenyl)-5-phenylhydantoin. "

Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART) 01/01/2011 - "However, folic acid deficiency was unrelated to either HAART or macrocytosis." 01/01/2011 - "The objective of this study was to correlate the presence of macrocytosis and anemia with HAART use or vitamin B12 and folic acid deficiencies. "
2.	Drug Therapy (Chemotherapy) 07/21/1977 - "Gingival hyperplasia and folic acid deficiency from anticonvulsive drug therapy: a theoretical relationship." 12/10/2002 - "Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice." 01/01/1991 - "There are sporadic case reports in the literature of its occurrence in association with herpex simplex virus encephalitis (HSVE), purulent meningitis, following chemotherapy for leukaemia, in a child with chronic renal failure, and in a child with folic acid deficiency. " 09/01/2006 - "Different factors, including vitamin B12 and folic acid deficiency, bone marrow suppression secondary to drug therapy, autoimmune hemolytic anemia and the coexistence of myelodysplastic syndromes are involved in the pathogenesis of anemia in IBD. " 04/07/2014 - "While iron deficiency is the most common cause, vitamin B12 and folic acid deficiencies, along with the effects of pro-inflammatory cytokines, hemolysis, drug therapies, and myelosuppression, have also been identified as the underlying etiology in a number of patients. "
3.	Intensive Care (Surgical Intensive Care) 12/01/1984 - "Folic acid deficiency in intensive care."
4.	Kidney Transplantation 12/01/1982 - "Relative folic acid deficiency does not seem to be responsible for macrocytosis after renal transplantation. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/02/1986 - "Acute folic acid deficiency after bone marrow transplantation."