Flurothyl (Flurotyl)

10/01/2014 - "Flurothyl inhalation-induced seizures were as clinically effective as electrical inductions with lesser effects on memory functions. "
10/01/2014 - "In 1957, seizure induction with the inhalant anesthetic flurothyl was tested and found to be clinically effective.For"
03/01/2011 - "Combining the Scn1a-R1648H and Scn8a-med-jo alleles restores normal thresholds to flurothyl-induced seizures in Scn1a(RH/+) heterozygotes and improved survival of Scn1a(RH/RH) homozygotes. "
04/01/2010 - "In the present study, we show that neonatal seizures induced by flurothyl result in markedly enhanced susceptibility of the neocortex to seizure-like activity. "
01/01/2009 - "Unlike C57BL/6J mice, DBA/2J mice had a lower GST on trial 1, did not demonstrate a decrease in GST across trials, nor did they show an alteration in seizure phenotype upon flurothyl retest. "

01/01/1975 - "25 Wistar rats were subjected twice daily to epileptic seizures induced by the convulsant gaz Flurothyl. "
09/30/2004 - "To evaluate the pathophysiological mechanism of subsequent reduced seizure threshold following neonatal seizures, single or recurrent prolonged seizures were induced to neonatal rats by the inhalant flurothyl. "
04/01/1995 - "Regarding generalized convulsive seizures, neuronal populations within the inferior and superior colliculi appear to regulate seizures in the genetic epilepsy-prone rat (GEPR) model, and subpopulations within the substantia nigra pars reticulata (SNR) appear to regulate seizures in the fluorothyl model. "
01/01/1989 - "Development of clonic-tonic flurothyl-induced seizures was examined in both normal and genetically epilepsy-prone rats (GEPRs). "
01/01/1989 - "Developing genetically epilepsy-prone rats have an abnormal seizure response to flurothyl."

08/05/1999 - "In the present study, effects of flurothyl-induced status epilepticus were examined in awake and free moving immature (2 weeks old) and adult rats. "
08/05/1999 - "Flurothyl status epilepticus in developing rats: behavioral, electrographic histological and electrophysiological studies."
01/01/2000 - "At P15, all animals were exposed to flurothyl-induced status epilepticus. "
08/05/1999 - "Young rats did not show alterations in paired-pulse perforant path inhibition following flurothyl status epilepticus. "
08/05/1999 - "In contrast, immature rats survived flurothyl status epilepticus for up to 60 min with a very low mortality. "

10/01/2013 - "In addition, perinatal hypoxia at P6 enhanced the rate of development of flurothyl kindling performed at P28-38 (p < 0.03), but not at P7-17. "
03/01/1993 - "In immature rats, immunoreactivity patterns after hypoxia were markedly different from PTZ or flurothyl: staining was confined to layer VI of neocortex in these animals, and rarely involved limbic structures. "
11/01/1992 - "In the present study, we evaluated whether hypoxia results in an increase in long-term seizure susceptibility to flurothyl and whether this is associated with impaired performance on behavioral tests. "
10/01/2013 - "Our data establish a mouse model of mild perinatal hypoxia in which we document the following: (1) the emergence, after a latent period, of increased susceptibility to flurothyl-induced seizures, and to flurothyl induced kindling; and (2) an additive effect of a gene mutation to the seizure predisposing consequences of perinatal hypoxia, thereby demonstrating that a modifier (or susceptibility) gene can exacerbate the long-term consequences of hypoxic injury."
10/01/2013 - "Effects of mutation: Kcn1a heterozygous mice subjected to P6 hypoxia exhibited increased susceptibility to flurothyl-induced seizures at P50 as compared to Normoxia heterozygote littermates, and to wild-type Hypoxia and Normoxia mice. "

02/01/1975 - "Strong flurothyl treatment (1.7% v/v for 8 min) produces retrograde amnesia in chicks when administered as long as 24 hr after one-trial avoidance training with a strongly aversive stimulus. "
08/01/1969 - "Retrograde amnesia was induced by treatment with flurothyl (CF(3)CH(2)-OCH(2)CF(3)) vapor. "
01/01/1968 - "Comparison of ECS and flurothyl-induced retrograde amnesia in mice."