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Flurazepam (Dalmane)

A benzodiazepine derivative used mainly as a hypnotic.

Also Known As:

Dalmane; Allphar Brand of Flurazepam Monohydrochloride; Apo-Flurazepam; Apotex Brand of Flurazepam Monohydrochloride; Dalmadorm; Dolorgiet Brand of Flurazepam; Dormodor; Flurazepam Dihydrochloride; Flurazepam Hydrochloride; Flurazepam Mono-Perchlorate; Flurazepam Monohydrochloride; ICN Brand of Flurazepam Monohydrochloride; Staurodorm; Apo Flurazepam; Dihydrochloride, Flurazepam; Flurazepam Mono Perchlorate; Hydrochloride, Flurazepam; Mono-Perchlorate, Flurazepam; Monohydrochloride, Flurazepam; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-

Networked: 141 relevant articles (21 outcomes, 16 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Benzazepines: 5
    - Benzodiazepines: 5199
      - Benzodiazepinones
        Flurazepam: 141
        didesethylflurazepam: 1
        7-chloro-5-(2'-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-1-acetaldehyde
        doxefazepam
        hydroxyethylflurazepam
        ID 622
        Ro 5-3367
        Ro 5-3438
        Ro7-AMCA
        SAS 646

Experts

1.	Abrahamowicz, Michal: 2 articles (04/2012 - 04/2006)
2.	Tamblyn, Robyn: 2 articles (04/2012 - 04/2006)
3.	Chen, Chia-Hui: 1 article (08/2014)
4.	Lin, Shih-Ku: 1 article (08/2014)
5.	Pan, Chun-Hung: 1 article (08/2014)
6.	Benavidez, J M: 1 article (04/2013)
7.	Harris, R A: 1 article (04/2013)
8.	Rudolph, U: 1 article (04/2013)
9.	Black, M: 1 article (04/2013)
10.	Chandra, D: 1 article (04/2013)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 07/01/1982 - "The short-term hypnotic efficacy of 15 mg flurazepam was evaluated in nine patients (mean age 37.2 +/- 15.9 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. " 12/01/1979 - "Under sleep-laboratory control, the efficacy of flurazepam hydrochloride (15 mg) was evaluated in 6 women (age range, 67-82 years) with objectively verified insomnia. " 08/01/2014 - "Flurazepam 30 mg was given before bedtime for insomnia. " 06/01/1989 - "In keeping with its long elimination half-life, flurazepam (30 mg) continued to exert beneficial effects for the first 2-3 withdrawal nights, but the possibility of a mild rebound insomnia cannot be dismissed during the intermediate withdrawal period (nights 4-10) following prolonged, consecutive, nightly administration (more than 30 nights). " 01/01/1988 - "Ten patients with subjective insomnia received 30 mg flurazepam or placebo on nights in which arousal thresholds in response to electronic tones or a recording of the subjects' names were determined. "
2.	Seizures (Seizure) 07/01/1992 - "This stress-induced reduction in the antiseizure efficacy of flurazepam is not due to a reduction in the threshold voltage for seizure production. " 07/01/1992 - "In this study, we examined the effect of treating mice with flurazepam 20 min prior to cold water swim stress on its ability to antagonize electrically precipitated seizures 24 h later. " 11/01/2009 - "The inbred Balb/c mouse strain was more sensitive than the outbred NIH Swiss mouse to flurazepam's ability to antagonize electrically precipitated seizures. " 08/01/1992 - "Twenty-four hours after mice were forced to swim for up to 10 min in cold (6 degrees C) water, the ability of flurazepam to antagonize the electrical precipitation of seizures was reduced. " 04/01/1988 - "Full convulsions were seen with FG7142 after the chronic administration of flurazepam, although this compound does not cause convulsions in normal mice of the strain used. "
3.	Apnea 12/01/1983 - "This alteration in arousal response may be the pathogenic mechanism of the increased duration of apnea reported in association with flurazepam." 08/01/1982 - "Flurazepam was associated with significant increases in the number of sleep events (p = 0.01), episodes of apnea (p less than 0.01), and total duration of apnea (p less than 0.01). " 04/01/1981 - "Upon cessation of medication, his clinical condition improved, and the number of apneas decreased to 11 and 6 on withdrawal nights 4 and 6. Although respiratory depression is neither invariable nor unique to flurazepam, this case suggests that it may be a clinically significant problem with recommended oral doses in some individuals." 11/01/1984 - "Acetazolamide did not protect individuals whose Apnea Index increased after flurazepam ingestion. " 12/01/1983 - "Increased episodes and duration of apnea during sleep associated with arterial oxygen desaturation have been reported after administration of flurazepam. "
4.	Tremor (Tremors) 09/01/1982 - "Flurazepam raised the threshold pressures for the onset of tremor and of clonic convulsions caused by high pressure helium. " 07/01/1982 - "2 Flurazepam hydrochloride 20 and 10 mg/kg and sodium valproate 800 and 400 mg/kg substantially raised the threshold pressures for both tremor and convulsions. " 01/07/1984 - "Low doses of flurazepam are effective against tremor but can be antagonized by Ro 15-1788, which implies in this case a role for the benzodiazepine receptor complex. "
5.	Respiratory Insufficiency (Respiratory Failure) 08/01/1986 - "[Respiratory depression following microinjection or intrathecal injection of flurazepam in rabbits]." 04/01/1981 - "Upon cessation of medication, his clinical condition improved, and the number of apneas decreased to 11 and 6 on withdrawal nights 4 and 6. Although respiratory depression is neither invariable nor unique to flurazepam, this case suggests that it may be a clinically significant problem with recommended oral doses in some individuals." 03/01/1992 - "Although no clinical signs of respiratory depression were observed with any long term treatment, flurazepam decreased oxygen saturation and inspiratory time and increased respiratory frequency. "

Related Drugs and Biologics

1.	Benzodiazepines
2.	Triazolam (Halcion)
3.	Estazolam (ProSom)
4.	Temazepam (Nocturne)
5.	Flurazepam (Dalmane)
6.	quazepam (Doral)
7.	Diazepam (Valium)
8.	Nitrazepam (Serenade)
9.	GABA-A Receptors (GABA(A) Receptor)
10.	Hypnotics and Sedatives (Sedatives)

Related Therapies and Procedures

1.	Injections
2.	Spinal Injections
3.	Intravenous Infusions
4.	Anesthesia