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Flunitrazepam (Rohypnol)

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A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

Also Known As:

Rohypnol; 1A Brand of Flunitrazepam; Fluni 1A Pharma; Flunibeta; Flunimerck; Fluninoc; Flunitrazepam-Teva; Flunitrazepam-neuraxpharm; Flunitrazepam-ratiopharm; Hexal Brand of Flunitrazepam; Merck dura Brand of Flunitrazepam; Narcozep; RO-5-4200; Roche Brand of Flunitrazepam; Rohipnol; Teva Brand of Flunitrazepam; betapharm Brand of Flunitrazepam; ct-Arzneimittel Brand of Flunitrazepam; flunizep von ct; neuraxpharm Brand of Flunitrazepam; ratiopharm Brand of Flunitrazepam; Flunitrazepam Teva; Flunitrazepam neuraxpharm; Flunitrazepam ratiopharm; RO54200; ct Arzneimittel Brand of Flunitrazepam; Fluridrazepam; 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-

Networked: 249 relevant articles (9 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Benzazepines: 5
    - Benzodiazepines: 5199
      - Benzodiazepinones
        Flunitrazepam: 249
        3-hydroxyflunitrazepam
        7-aminodesmethylflunitrazepam
        7-aminoflunitrazepam
        desmethylflunitrazepam
        N-desmethylflunitrazepam

Experts

1.	Svensson, Anders I: 3 articles (05/2009 - 05/2003)
2.	Mørland, Jørg: 2 articles (01/2015 - 06/2006)
3.	Hipólide, Débora Cristina: 2 articles (02/2012 - 03/2005)
4.	Ameno, Kiyoshi: 2 articles (01/2011 - 07/2008)
5.	Kinoshita, Hiroshi: 2 articles (01/2011 - 07/2008)
6.	Ricordel, Ivan: 2 articles (11/2008 - 08/2004)
7.	Milan, Nathalie: 2 articles (11/2008 - 08/2004)
8.	Borron, Stephen W: 2 articles (11/2008 - 07/2005)
9.	Megarbane, Bruno: 2 articles (11/2008 - 07/2005)
10.	Baud, Frédéric J: 2 articles (11/2008 - 07/2005)

Related Diseases

1.	Seizures (Seizure) 01/01/1990 - "The treatment cleared the mice of the pinworm infestation, but did not alter the seizure susceptibility or binding parameters of [3H]flunitrazepam in either of the selected lines." 06/26/1998 - "Neither one nor five seizures altered [3H]flunitrazepam binding." 01/01/1995 - "Add-on therapy with flunitrazepam (FNZ) was performed in 5 children with marked sleep disturbance and intractable seizures. " 09/01/1990 - "These data suggest that the decrease in [3H]flunitrazepam binding in stimulated El mice may be due mainly to that of type 1 receptor and may be the result of repeated convulsions." 09/01/1990 - "Specific [3H]flunitrazepam binding in stimulated El mice, which had experienced repeated convulsions, was significantly lower in the cortex and hippocampus than in ddY mice and unstimulated El mice. "
2.	Sleep Initiation and Maintenance Disorders (Insomnia) 12/18/1980 - "[Study of flunitrazepam in the insomnia of the aged (author's transl)]." 12/18/1980 - "The efficiency of flunitrazepam was evaluated on the three phases of sleep in 20 patients 65 years old and more hospitalized suffering from severe insomnia. " 11/01/1980 - "Although the safe dosage range is wide with flunitrazepam, its effective application both as a hypnotic for insomnia and in anaesthesiology is dependent upon use of the optimal dosage, and adequate knowledge of its pharmacokinetic properties." 10/01/2007 - "Although intravenous midazolam and flunitrazepam are frequently administered for primary insomnia in Japan, there is no empirical study on their efficacy and safety. " 01/01/1995 - "During the early treatment of a major depressive episode with amitryptiline, insomnia was treated in 81 patients in a double-blind comparative trial comparing zopiclone and flunitrazepam. "
3.	Neoplasms (Cancer) 10/15/1988 - "Total [3H]Ro5-4864 or [3H]flunitrazepam binding to these sections was indistinguishable from nonspecific binding, and regions of tumor and normal brain could not be delineated. " 07/01/1990 - "Intravenous injection of [3H]flunitrazepam resulted in a tumor/cortex ratio of radioactive densities between 2.7 and 1.5 within the first 60 minutes after injection. " 05/01/1994 - "Clear differences were observed in the competition by both diazepam and flunitrazepam for binding sites in m- and p-fractions from tumors. " 07/01/1990 - "[3H]PK 11195 demonstrated a higher tumor/cortex ratio (5.3) than [3H]flunitrazepam. " 04/01/1994 - "Intracranial pressure, cerebral perfusion pressure, and intracerebral blood volume changes were observed in 43 patients with volumetric intracranial processes (intracranial hematomas, tumors) during general rohypnol anesthesia. "
4.	Status Epilepticus (Complex Partial Status Epilepticus) 10/01/1989 - "Flunitrazepam (FZP) was administered intravenously, with success, to two patients with status epilepticus. " 10/01/1989 - "Intravenous flunitrazepam for status epilepticus." 01/01/1988 - "Intravenous injection of flunitrazepam for status epilepticus in children--two case reports." 01/01/1988 - "Flunitrazepam might have a potential efficacy for the treatment of status epilepticus of both generalized and partial seizures." 01/01/1988 - "Two cases of status epilepticus are reported, whose seizures responded well to the injection of flunitrazepam. "
5.	Tremor (Tremors) 03/23/2005 - "Mouse GAT1 (mGAT1) KO mice exhibit motor disorders, including gait abnormality, constant 25-32 Hz tremor, which is aggravated by flunitrazepam, reduced rotarod performance, and reduced locomotor activity in the home cage. " 07/01/1994 - "Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2',2''-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. " 07/01/1994 - "The inhibitory effects of diazepam and flunitrazepam on the 2,2',2''-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). " 08/21/1987 - "Moreover, tabernanthine-induced tremor was inhibited reversibly by flunitrazepam or by Ro-15 1788 (an antagonist of benzodiazepine-receptors). " 04/01/1995 - "Injection of the specific benzodiazepine receptor antagonist flumazenil (10 mg/kg i.v.) 5 h after the ninth daily oral treatment produced signs of precipitated withdrawal (tremor, vomiting and/or convulsions) in one alprazolam-, four diazepam-, one flunitrazepam- and four oxazepam-treated monkeys, but not in the vehicle-treated monkeys. "

Related Drugs and Biologics

1.	Triazolam (Halcion)
2.	zolpidem (Ambien)
3.	zopiclone (Zop)
4.	Benzodiazepines
5.	Nitrazepam (Serenade)
6.	GABA-A Receptors (GABA(A) Receptor)
7.	Diazepam (Valium)
8.	Pentobarbital (Nembutal)
9.	Temazepam (Nocturne)
10.	Antidepressive Agents (Antidepressants)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intramuscular Injections
3.	Premedication
4.	Ligation
5.	Spinal Anesthesia