Flumazenil (Romazicon)

08/01/1997 - "In a placebo-controlled study involving patients with mild hepatic encephalopathy, a low dose of flumazenil (0.2 mg/kg) resulted in a significant improvement in reaction time.Research"
04/01/1995 - "The infusion of 0.4-1 mg flumazenil results in a modest but rapid improvement in the EEG grading of hepatic encephalopathy and to a moderate but delayed improvement in the clinical grade of hepatic encephalopathy."
03/01/2006 - "Is flumazenil an effective treatment for hepatic encephalopathy?"
01/01/1994 - "To test this possibility, we conducted a double-blind, placebo-controlled crossover trial of the efficacy of flumazenil in cirrhotic patients in hepatic coma. "
04/01/1995 - "During 12 episodes of hepatic encephalopathy, flumazenil was administered and the EEG recording improved within 7 min (range 4-47 min; 12 out of 18 cases; 66 versus 0% for flumazenil versus placebo, respectively; P < 0.01); a modest clinical improvement in hepatic encephalopathy was observed within 83 min (range 30-340 min). "

08/01/1988 - "With efficacious doses of 0.2 mg-0.4 mg the Flumazenil group showed a significant improvement in collaboration and in reversing sedation and amnesia up to 30 min after the injection of the antagonist. "
09/01/1990 - "The amnesia was eliminated by flumazenil in 34 patients (72%). "
01/01/1988 - "The amnesia was totally eliminated by flumazenil. "
07/01/2012 - "On the basis of the results of flumazenil administration in this and a previous case report, we would recommend a trial dose of 0.2 mg for cases of global postoperative amnesia, repeated if the first dose seems effective."
08/01/1988 - "At the end of operations Flumazenil was i.v. injected in incremental doses up to the awakening of the patient or to a maximal dose of 1 mg. The parameters of efficacy (degree of sedation, amnesia, orientation and collaboration) and safety (vital signs, vital capacity), adverse reactions and the patient's subjective assessment were recorded up to 240 min after the injection of the trial drug. "

11/12/1986 - "Animals treated with Ro 15-1788 still expressed lower behavioral stages when Ro 15-1788 was eliminated from the trials indicating that this compound suppresses the very process of kindling itself and not just the expression of the kindled seizures. "
06/01/1991 - "Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit."
10/01/2012 - "The objectives of the study were: to determine the frequency of seizures among acutely poisoned adults administered flumazenil; to identify factors associated with seizures; and to determine the mental status of subjects before and after administration of flumazenil. "
06/01/1995 - "In this study, we examined the effect of absence seizures on the binding of flumazenil to the BZD binding site of the GABAA receptor. "
01/19/1991 - "Electroencephalographic studies in 6 patients with partial and 6 with generalised seizures showed that flumazenil had a short (20 min) non-dose-dependent suppressant effect on epileptic discharges in those with partial seizures. "

01/01/2002 - "Flumazenil bolus administration was associated with an improvement in Glasgow Coma Score from 7 +/- 1 to 13 +/- 1 in the nonintubatedpatients, and from 5 +/- 1 to 11 +/- in the intubated patients. "
01/01/1994 - "There are a few case reports which suggest that flumazenil can be used as a diagnostic tool in coma of unknown aetiology but no large scale studies have proved its efficacy and cost-effectiveness. "
02/01/2007 - "Coma cocktail: a role for flumazenil?"
01/01/2004 - "Flumazenil administration had no impact on clinical advancement of coma. "
05/01/1998 - "For severe BZ intoxication, treatment with flumazenil infusion should still be considered skeptically and should not be recommended as routine management BZ-intoxicated patients with an underlying disease, an older age, and resedation into a deep comatose state after showing an initial response to flumazenil should be treated in an intensive care unit."

07/01/2007 - "Studies were included if patients who presented with altered mental state from suspected drug poisoning were treated with intravenous flumazenil as compared to placebo. "
07/01/2012 - "Factors associated with flumazenil use were increased age, severe poisoning and ventilatory failure. "
01/01/2007 - "13) Flumazenil is not recommended for patients with TCA poisoning (Grade D)."
01/01/1991 - "Re-sedation occurred in about 65% of flumazenil treated patients, usually within 0.5-3 h after the first dose, the shorter interval being associated with mixed-drug poisoning. "
01/01/1991 - "The use of flumazenil in the management of acute drug poisoning--a review."