Flufenamic Acid

An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)

Also Known As:

Networked: 81 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dell'Orco, James M: 1 article (08/2015)
2.	Wasserman, Aaron H: 1 article (08/2015)
3.	Orr, Harry T: 1 article (08/2015)
4.	Opal, Puneet: 1 article (08/2015)
5.	Hu, Yuan-Shih: 1 article (08/2015)
6.	Wulff, Heike: 1 article (08/2015)
7.	Shakkottai, Vikram G: 1 article (08/2015)
8.	Ingram, Melissa A C: 1 article (08/2015)
9.	Chopra, Ravi: 1 article (08/2015)
10.	Singh, Vikrant: 1 article (08/2015)

Related Diseases

1.	Migraine Disorders (Migraine) 08/01/1979 - "Efficacy of flufenamic acid in migraine attacks." 07/01/1985 - "Flufenamic acid in prostaglandin migraine." 09/01/1999 - "We then concluded that the i.v. infusion of the NSAID LC (2-3-chloro-o-toluidin)piridin-3-lysine carboxilate), a derived from the nicotinic acid with a chemical structure that resembles the flufenamic acid, was efficient abolishing a severe migraine attack after 90 minutes in 19 patients. " 01/01/1977 - "Ophthalmoplegic migraine: amelioration by Flufenamic acid, a prostaglandin inhibitor." 01/01/1977 - "Based on this hypothesis a therapeutic trial with flufenamic acid (a prostaglandin inhibitor of the fenamates group) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine. "
2.	Pain (Aches) 01/01/1981 - "Thirty-four patients completed the two 3-week test periods and twenty-one patients were improved in relation to morning stiffness and pain by flufenamic acid and twelve patients by placebo--a difference greater than would have occurred by chance (p = 0.05). " 05/18/1968 - "Double-blind evaluation of the analgesic and toxic effects of flufenamic acid and mefenamic acid in patients with chronic pain." 01/01/1966 - "Evaluation of mefenamic acid and flufenamic acid in clinical pain." 06/01/2010 - "A review of 25 cases of heel pain treated conservatively with phonophoresis, using the anti-inflammatory gel containing a combination of flufenamic acid, salicylic acid and mucopolysaccharide polysulphate is being reported here. "
3.	Rheumatoid Arthritis 05/01/1966 - "VII. A controlled trial of flufenamic acid therapy in rheumatoid arthritis." 07/15/1968 - "[Flufenamic acid in the therapy of rheumatoid arthritis]." 12/22/1967 - "Flufenamic acid in rheumatoid arthritis." 01/01/1967 - "Controlled clinical trial of flufenamic acid in rheumatoid arthritis." 01/01/1967 - "Flufenamic acid in rheumatoid arthritis."
4.	Ankylosing Spondylitis 05/01/1968 - "A controlled study of flufenamic acid in ankylosing spondylitis. " 01/01/1966 - "A controlled study of flufenamic acid in ankylosing spondylitis. "
5.	Arthritis (Polyarthritis) 12/01/1992 - "Pharmacokinetics of etofenamat and flufenamic acid in plasma, synovium, and tissues of patients with chronic polyarthritis after administration of an oily solution of etofenamat]." 11/01/1967 - "[Evaluation of the therapeutic action of flufenamic acid in patients with chronic polyarthritis in a double blind study]." 05/11/1974 - "Oxyphenbutazone and flufenamic acid in the treatment of osteo-arthritis of the knee. " 12/01/1992 - "Studies on Plasma and Tissue Concentrations of Etofenamate following Intramuscular Application/Pharmacokinetics of etofenamate and flutenamic acid in plasma, synovia and tissues of patients with chronic polyarthritis after application of oily etofenamat solution Pharmacokinetics of etofenamate (ETO, CAS 30544-47-9; Rheumon i.m.) and flufenamic acid (FLU, CAS 530-78-9) were investigated in plasma, synovial fluid, and tissues after single intramuscular application of etofenamate to patients with rheumatoid arthritis. " 08/01/1982 - "In particular, the anti-erythema, anti-arthritis, and anti-pyretic activities of etofenamate were approximately equivalent to or superior to those of flufenamic acid. "

Related Drugs and Biologics

1.	Ibuprofen (Motrin)
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
3.	Indomethacin (Indometacin)
4.	Mefenamic Acid (Pontal)
5.	Aspirin (Acetylsalicylic Acid)
6.	etofenamate
7.	anthranilic acid (anthranilate)
8.	Piroxicam (Feldene)
9.	Naproxen (Naprosyn)
10.	Chlorpromazine (Thorazine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Phonophoresis