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Fludrocortisone

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A synthetic mineralocorticoid with anti-inflammatory activity.

Also Known As:

9 alpha Fludrohydrocortisone; 9 alpha-Fluoro-17-Hydroxycorticosterone; 9 alpha-Fluorohydrocortisone; 9-Fluoro-17-Hydroxycortisone; 9-Fluorohydrocortisone; Astonin; Astonin Merck; Astonin-H; FCOL; Merck Brand of Fludrocortisone; 9 Fluoro 17 Hydroxycortisone; 9 Fluorocortisol; 9 Fluorohydrocortisone; 9 alpha Fluoro 17 Hydroxycorticosterone; 9 alpha Fluorohydrocortisone; Astonin H; Merck, Astonin; 9-Fluorocortisol; Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-

Networked: 286 relevant articles (36 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Pregnanes: 3
    - Pregnenes
      - Pregnenediones
        Hydrocortisone: 15970
        Fludrocortisone: 286
        fludrocortisone acetate: 54
        2 alpha-methyl-9 alpha-fluorocortisol: 1
        dicortineff: 1
        6-dehydrofluorocortisol acetate
        Panotile

Experts

1.	Annane, Djillali: 9 articles (05/2013 - 08/2002)
2.	Bellissant, Eric: 6 articles (06/2014 - 08/2002)
3.	Stowasser, Michael: 4 articles (04/2015 - 11/2003)
4.	Gordon, Richard D: 4 articles (04/2015 - 11/2003)
5.	Laviolle, Bruno: 3 articles (06/2014 - 08/2012)
6.	Løvås, Kristian: 3 articles (03/2009 - 05/2002)
7.	Stowasser, M: 2 articles (06/2015 - 06/2001)
8.	Otte, Christian: 2 articles (04/2015 - 10/2006)
9.	Ahmed, Ashraf H: 2 articles (04/2015 - 08/2014)
10.	Wolley, Martin: 2 articles (01/2015 - 08/2014)

Related Diseases

1.	Orthostatic Hypotension (Postural Hypotension) 07/01/1990 - "The orthostatic hypotension of the patient as effectively treated with fludrocortisone. " 02/01/2000 - "The aim of the present study was to examine whether the improvement in orthostatic blood pressure during combined treatment with low-dose fludrocortisone and nocturnal head-up tilt in patients with neurogenic orthostatic hypotension can be attributed to expansion of plasma volume or to increased total peripheral resistance. " 08/01/2005 - "Since only fludrocortisone negatively altered gene expression, we assessed fludrocortisone's efficacy in treating postural hypotension, and its effect on survival and secondary long-term FD problems. " 02/01/2000 - "The improvement in upright blood pressure in orthostatic hypotension during treatment with fludrocortisone and nocturnal head-up sleeping is the result of a reduction in the orthostatic decrease in cardiac output. " 08/01/2011 - "Fludrocortisone is a reasonable first choice for symptomatic orthostatic hypotension. "
2.	Adrenal Insufficiency (Adrenal Gland Hypofunction) 05/01/2013 - "This method allows fludrocortisone pharmacokinetic/pharmacodynamic studies when given at low dosage in an intensive care unit in case of adrenal insufficiency during a septic shock." 11/01/2005 - "Recent studies have proven that low doses of hydrocortisone and fludrocortisone can significantly reduce mortality in patients with relative adrenal insufficiency (RAI) without increasing adverse events. " 01/01/2011 - "The patient was known with Adrenal insufficiency and was treated optimally with fludrocortisone and prednisolone since seven years with no history of adrenal crisis. " 04/01/1986 - "Adverse effect of phenytoin on mineralocorticoid replacement with fludrocortisone in adrenal insufficiency." 08/20/1955 - "Metabolic effects of 9 alpha-fluorohydrocortisone and of cortisone in adrenal insufficiency."
3.	Body Weight (Weight, Body) 05/01/1993 - "Body weight recorded after 10 days of fludrocortisone administration was higher on placebo compared to KCl (72.3 +/- 2.8 vs. 71.6 +/- 2.8 kg, P = 0.01). " 03/01/2001 - "There were no significant changes in body weight, pulse rate, or BP after treatment with salt and fludrocortisone. " 08/01/1991 - "Chronic volume expansion by head-up tilt at night and fludrocortisone resulted in a marked improvement in orthostatic blood pressure control at a comparable increment in body weight and sodium balance for the next 7 years until now. " 04/01/1995 - "In the short protocol, fludrocortisone increased platelet cytosolic calcium and body weight by day 3, while BP was increased by day 7. In the long protocol, platelet cytosolic calcium was increased after 1 week, returned to basal values by 3 weeks and remained at that level for the rest of the study. " 07/01/1998 - "Fludrocortisone caused an increase in body weight and no significant reduction in serum potassium concentration, while spironolactone decreased body weight and increased plasma potassium concentration. "
4.	Hypoaldosteronism (Hyporeninemic Hypoaldosteronism) 01/01/2012 - "In this paper, we report a case of a woman diagnosed with autoimmune polyglandular syndrome type 2. As a consequence of adrenal cortex destruction, the patient developed subclinical hypoaldosteronism which was effectively treated with small doses of fludrocortisone. " 12/01/2011 - "Obviously treatment of a corticotropic deficit, even subtle, should not be overlooked, as well as the introduction of fludrocortisone in isolated hypoaldosteronism and discontinuation of iatrogenic drugs." 03/01/2009 - "Three siblings of Pakistani origin presented neonatally with isolated hyperreninemic hypoaldosteronism and were well controlled on fludrocortisone therapy during childhood and adolescence. " 08/01/1992 - "Administration of fludrocortisone can rapidly alleviate the signs and symptoms of hyporeninemic hypoaldosteronism. " 11/01/2012 - "Persistent postoperative hypoaldosteronism with hyperkalemia occurs in 5% of adrenalectomized PA patients through prolonged ZG insufficiency, requiring long-term fludrocortisone treatment. "
5.	Hypertension (High Blood Pressure) 05/01/2007 - "She improved with fludrocortisone, however, this had to be discontinued due to a supine hypertension and peripheral edemas. " 06/01/2015 - "At post-operative follow up, those with CS had a lower systolic BP (SBP; 128mmHg vs. 144mmHg p=0.001), a greater proportion with cure or improvement of hypertension (96% vs 64%, p = 0.0034), a greater proportion with biochemical cure of PA on fludrocortisone suppresion testing (43/49 (88%) vs 4/9 (44%), p = 0.002) and were on a lower number of antihypertensive medications (0 vs 1.5, p = 0.0032). " 04/01/2015 - "At postoperative follow-up, those with CS had lower systolic BP (SBP) (128 mm Hg vs 144 mm Hg, P = .001), a greater proportion with cure or improvement of hypertension (96% vs 64%, P = .0034), a greater proportion with biochemical cure of PA on fludrocortisone suppression testing (43 of 49 [88%] vs 4 of 9 [44%], P = .002) and were taking a lower median number of antihypertensive medications (0 vs 1.5, P = .0032). " 10/01/2001 - "Adverse cardiac effects of salt with fludrocortisone in hypertension." 03/01/2001 - "Adverse cardiac effects of salt with fludrocortisone in hypertension."

Related Drugs and Biologics

1.	Hydrocortisone (Cortisol)
2.	Furosemide (Lasix)
3.	Potassium
4.	Dexamethasone (Maxidex)
5.	Tacrolimus (Prograf)
6.	Insulin (Novolin)
7.	Sodium
8.	Ephedrine
9.	Dihydroergotamine (Agit)
10.	Steroids

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Aftercare (After-Treatment)
3.	Compression Stockings
4.	Renal Dialysis (Hemodialysis)
5.	Drug Therapy (Chemotherapy)