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Flecainide (Tambocor)

A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial arrhythmias and tachycardias. Paradoxically, however, in myocardial infarct patients with either symptomatic or asymptomatic arrhythmia, flecainide exacerbates the arrhythmia and is not recommended for use in these patients.

Also Known As:

Tambocor; R818; 3M Brand of Flecainide Acetate; Alphapharm Brand of Flecainide Acetate; Alpharma Brand of Flecainide Acetate; Apocard; Flecadura; Flecainid-Isis; Flecainide Monoacetate; Flecainide Monoacetate, (+-)-Isomer; Flecainide Monoacetate, (R)-Isomer; Flecainide Monoacetate, (S)-Isomer; Flecainide, (R)-Isomer; Flecainide, (S)-Isomer; Flecainide, 5-HO-N-(6-oxo)-Derivative; Flecainide, 5-HO-N-(6-oxo)-Derivative, (+-)-Isomer; Flecatab; Flécaïne; Merck dura Brand of Flecainide Acetate; Riker Brand of Flecainide Acetate; United Drug Brand of Flecainide Acetate; Acetate, Flecainide; Flecainid Isis; Flecainide Acetate; Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-

Networked: 910 relevant articles (149 outcomes, 154 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - Flecainide: 910
      - 5-hydroxy-N-(2-piperidinylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide: 2

Experts

1.	Kuga, Keisuke: 10 articles (08/2015 - 08/2002)
2.	Homma, Masato: 10 articles (08/2015 - 08/2002)
3.	Kohda, Yukinao: 9 articles (07/2013 - 08/2002)
4.	Doki, Kosuke: 8 articles (08/2015 - 09/2004)
5.	Wilde, Arthur A M: 8 articles (03/2015 - 03/2004)
6.	Yamaguchi, Iwao: 6 articles (10/2007 - 08/2002)
7.	Aonuma, Kazutaka: 5 articles (08/2015 - 10/2007)
8.	Osadchii, Oleg E: 4 articles (02/2016 - 07/2012)
9.	Tan, Hanno L: 4 articles (02/2015 - 03/2004)
10.	Brugada, Ramon: 4 articles (01/2014 - 04/2004)

Related Diseases

1.	Atrial Fibrillation 11/01/2004 - "It has been reported that i.v. flecainide has a high efficacy for the treatment of experimentally-induced acute atrial fibrillation (AF) in horses and that its use is associated with minimal toxic side effects. " 01/25/1996 - "Although both drugs were equally effective in adequately controlling recurrences of atrial fibrillation (difference, p = 0.282; not significant), fewer flecainide patients had to have their therapy discontinued due to adverse experiences (p = 0.012). " 07/01/1987 - "Flecainide therefore appears to be effective in reducing recent atrial fibrillation on a non-dilated atrium. " 02/01/2011 - "Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation." 11/01/2004 - "The objectives were to study the efficacy of i.v. flecainide as a treatment for atrial fibrillation in horses with naturally-occurring AF. "
2.	Tachycardia (Tachyarrhythmias) 01/01/1988 - "This experience demonstrates that flecainide is highly effective in refractory atrial tachyarrhythmias. " 11/01/1985 - "Flecainide acetate is a recently introduced, class 1 antiarrhythmic agent that is highly effective in the treatment of ventricular and atrioventricular/nodal reentrant tachycardias. " 04/01/1990 - "Two infants with chaotic atrial tachycardia diagnosed at birth and at 11 weeks of life, were treated successfully with oral flecainide. " 10/01/1989 - "Efficacy of flecainide in pacing-induced sustained ventricular tachyarrhythmias: correlation to clinical parameters and tachycardia-characteristics." 08/01/1987 - "We conclude that (1) flecainide acetate is effective for the treatment of various tachycardias associated with Mahaim fibres; (2) since different mechanisms responsible for the tachycardia with LBBBM may be present in the same patient and difficult to determine in some, treatment with flecainide acetate which affects both the atrioventricular node and Mahaim fibre conduction may be appropriate for the condition and; (3) its use should be considered before more aggressive therapies."
3.	Supraventricular Tachycardia 02/01/2002 - "Flecainide is safe and highly effective in the intrauterine treatment of hydropic fetuses with supraventricular tachycardia. " 01/01/1990 - "Based on the history and ECG flecainide had been effective in 51 pts. The improvement was most pronounced in pts suffering from supraventricular tachycardia involving an accessory bypass tract (84-92%). " 07/01/1986 - "The electrophysiologic effects and therapeutic efficacy of intravenous and oral flecainide were studied in 15 patients with spontaneous and inducible sustained paroxysmal supraventricular tachycardia (SVT). " 05/01/1995 - "Electrophysiologic effects and therapeutic efficacy of intravenous flecainide for termination of paroxysmal supraventricular tachycardia." 03/01/1987 - "This experience indicates that flecainide, which has not been used extensively in children, is an effective and safe antiarrhythmic agent, capable of terminating and controlling supraventricular tachycardia in children. "
4.	Ventricular Tachycardia 03/01/1988 - "Administered orally, flecainide is very effective in decreasing ventricular ectopic activity (80% to 95%) and nonsustained ventricular tachycardia. " 11/01/1993 - "Flecainide seems more effective for sustained ventricular tachycardia than for nonsustained ventricular tachycardia." 03/01/1986 - "In summary, intravenous flecainide is effective for slowing and termination of stable ventricular tachycardia. " 03/01/1988 - "The electrophysiologic effects and antiarrhythmic efficacy of flecainide were evaluated by electrophysiologic study (EPS) in 20 patients with ventricular tachycardia (VT) refractory to an average 2.9 drugs. " 06/30/1989 - "[Efficacy of flecainide in the treatment of ventricular tachycardia in the elderly. "
5.	Cardiac Arrhythmias (Arrythmia) 07/01/2012 - "Patient's arrhythmia burden was eliminated following successful treatment with flecainide." 08/20/1992 - "Flecainide appears to be effective in preventing PAF, with 65% of patients being arrhythmia-free after 9 months of treatment at a mean daily dose of 200 mg. Side effects were common, but clinically significant adverse events were infrequent." 06/01/1990 - "It is concluded that flecainide acetate is effective in a wide range of cardiac arrhythmias, and that long-term management problems are few." 12/01/1989 - "Thus, flecainide may be effective in postponing arrhythmia recurrence, even in difficult-to-treat patients. " 08/01/1982 - "These electrophysiological properties strongly suggest that flecainide will be useful in the management of a wide variety of cardiac arrhythmias. "

Related Drugs and Biologics

1.	Propafenone (Rythmol)
2.	Amiodarone (Amiodarona)
3.	Encainide
4.	Mexiletine (Mexitil)
5.	Quinidine (Chinidin)
6.	Sotalol (Sotalol Hydrochloride)
7.	Digoxin (Digitek)
8.	Lidocaine (Xylocaine)
9.	Flecainide (Tambocor)
10.	cifenline (cibenzoline)

Related Therapies and Procedures

1.	Electric Countershock (Cardioversion)
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Intensive Care (Surgical Intensive Care)
5.	Intravenous Infusions