Flavodoxin

A low-molecular-weight (16,000) iron-free flavoprotein containing one molecule of flavin mononucleotide (FMN) and isolated from bacteria grown on an iron-deficient medium. It can replace ferredoxin in all the electron-transfer functions in which the latter is known to serve in bacterial cells.

Networked: 22 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carrillo, Néstor: 3 articles (01/2016 - 07/2007)
2.	Sancho, Javier: 3 articles (01/2016 - 11/2009)
3.	Velázquez-Campoy, Adrián: 2 articles (01/2016 - 11/2009)
4.	Hoffman, Paul S: 2 articles (08/2013 - 11/2009)
5.	Battu, Anamika: 1 article (01/2021)
6.	Dey, Partha: 1 article (01/2021)
7.	Kaur, Rupinder: 1 article (01/2021)
8.	Purushotham, Rajaram: 1 article (01/2021)
9.	Vamshi, S Surya: 1 article (01/2021)
10.	Cao, Duanfang: 1 article (01/2020)

Related Diseases

1.	Infections 11/20/2009 - "Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection." 08/08/2013 - "Improved flavodoxin inhibitors with potential therapeutic effects against Helicobacter pylori infection." 11/01/2013 - "Here, using knock-out (KO) and overexpressing lines, we studied the protective role of two groups of Arabidopsis thaliana cytosolic QRs, Nqr (NAD(P)H:quinone oxidoreductase) and Fqr (flavodoxin-like quinone reductase), in response to infection by necrotrophic fungi. " 01/01/2011 - "It appeared that adenylosuccinate synthetase, flavodoxin, and LivJ, the substrate binding protein of a branched-chain amino acid ABC transporter, are relevant as targets for future therapy and prevention of pneumococcal meningitis, since their mutants were attenuated in both models of infection as well as in competitive growth in human cerebrospinal fluid in vitro."
2.	Wounds and Injuries (Trauma) 11/01/1998 - "A flavodoxin from Azotobacter vinelandii is chosen as a model system to study the folding of alpha/beta doubly wound proteins. "
3.	Starvation 03/01/2015 - "We evaluated expression of genes encoding flavodoxin (FLDA1) and an Fe-starvation induced protein (ISIP3) as indicators of Fe limitation in the marine diatom Thalassiosira oceanica. " 02/16/2015 - "The flavodoxin gene was lost in the course of plant evolution, but its reintroduction in transgenic plants confers increased tolerance to environmental stress and iron starvation, raising the question as to why a genetic asset with obvious adaptive value was not kept by natural selection. " 04/01/2009 - "Fur-independent induction of Helicobacter pylori flavodoxin-encoding gene (fldA) under iron starvation." 10/01/2016 - "While at phase I no significant changes in physiological parameters were observed, molecular markers for iron starvation, such as Iron Starvation Induced Protein and flavodoxin, were highly up-regulated. " 01/01/2016 - "Transgenic tobacco plants expressing a plastid-targeted cyanobacterial flavodoxin, a flavoprotein that prevents ROS accumulation specifically in chloroplasts, displayed increased tolerance to many environmental stresses, including drought, excess irradiation, extreme temperatures and iron starvation. "
4.	Iron Deficiencies 11/01/2019 - "phaeovibrioides appears thus to be a new type of the photosynthetic organisms that can use flavodoxin as an alternative electron carrier to cope with iron deficiency." 06/01/2003 - "Flavodoxin and ferredoxin have been frequently used as markers for determination of iron deficiency in phytoplankton. " 06/01/2003 - "Development of an ELISA approach for the determination of flavodoxin and ferredoxin as markers of iron deficiency in phytoplankton." 06/01/1996 - "Insertional mutagenesis of the cloned cyanobacterial fur gene led to the creation of heteroallelic mutants that showed iron-deficiency symptoms in iron-replete medium, including the constitutive production of flavodoxin and of hydroxamate siderophores. " 01/01/2020 - "Under iron-deficiency stress, which occurs frequently in natural aquatic environments, cyanobacteria reduce the amount of iron-enriched proteins, including photosystem I (PSI) and ferredoxin (Fd), and upregulate the expression of iron-stress-induced proteins A and B (IsiA and flavodoxin (Fld)). "
5.	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 01/01/2011 - "It appeared that adenylosuccinate synthetase, flavodoxin, and LivJ, the substrate binding protein of a branched-chain amino acid ABC transporter, are relevant as targets for future therapy and prevention of pneumococcal meningitis, since their mutants were attenuated in both models of infection as well as in competitive growth in human cerebrospinal fluid in vitro."

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Proteins (Proteins, Gene)
3.	Iron
4.	Flavoproteins
5.	Ferredoxins (Ferredoxin)
6.	Aspartic Acid Proteases
7.	Pyruvate Synthase (Synthase, Pyruvate)
8.	Photosystem I Protein Complex (Photosystem I)
9.	Membrane Transport Proteins (Biological Pump)
10.	ATP-Binding Cassette Transporters (ABC Transporters)

Related Therapies and Procedures

1.	Therapeutics