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Bis(4- Methyl- 1- Homopiperazinylthiocarbonyl)disulfide
An inhibitor of the last step of noradrenaline biosynthesis.
Also Known As:
FLA 63; 1H-1,4-Diazepine, 1,1'-(dithiodicarbonothioyl)bis(hexahydro-4-methyl)
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide: 4
Related Diseases
1.
Decapitation
07/15/1979 - "
Depletion of brain noradrenaline by synthesis inhibition with DDC, FLA 57 or FLA 63 g reduced the duration of the post-decapitation convulsion.
"
2.
Pain (Aches)
04/01/1976 - "
The effect of H 77/77 upon the V and VA pain responses was abolished or reduced by prior treatment with phenoxybenzamine, chlorpromazine, H 44/68, FLA 63, reserpine and protriptyline, and was potentiated by atropine sulphate.
"
3.
Hyperalgesia
01/24/1994 - "
Depletion of endogenous catecholamines with reserpine or alpha-methyl-DL-p-tyrosine and inhibition of noradrenaline synthesis with FLA 63 reduced the theophylline-induced hyperalgesia, whereas blockade of dopamine D2 receptors by pimozide, haloperidol (2 mg/kg) or (-)-sulpiride, of dopamine D1 receptors by SCH 23390, or of dopamine autoreceptors by a low dose of haloperidol (25 micrograms/kg), had no effect.
"
4.
Ataxia (Dyssynergia)
01/01/1979 - "
The phase of activation + ataxia was reduced by pretreatment of rats with H 44/68, FLA 63, reserpine, pimozide, phenoxybenzamine, oxypertine or chlorpromazine.
"
Related Drugs and Biologics
1.
Reserpine (Serpasil)
2.
Pimozide (Orap)
3.
Phenoxybenzamine
4.
Norepinephrine (Noradrenaline)
5.
Chlorpromazine (Thorazine)
6.
Autoreceptors
7.
Dopamine D2 Receptors (Dopamine D2 Receptor)
8.
Dopamine D1 Receptors (Dopamine D1 Receptor)
9.
Tyrosine (L-Tyrosine)
10.
Theophylline (Theon)