Monostotic Fibrous Dysplasia

FIBROUS DYSPLASIA OF BONE involving only one bone.

Also Known As:

Fibrous Dysplasia, Monostotic; Dysplasia, Monostotic Fibrous; Dysplasias, Monostotic Fibrous; Fibrous Dysplasias, Monostotic; Monostotic Fibrous Dysplasias

Networked: 25 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Bone Diseases: 5863
  - Developmental Bone Diseases: 153
    - Osteochondrodysplasias: 592
      - Fibrous Dysplasia of Bone: 78
        Monostotic Fibrous Dysplasia: 25

Related Diseases

1.	Pain (Aches)
2.	Cholesteatoma
3.	Pathologic Constriction (Stenosis)
4.	Polyostotic Fibrous Dysplasia (McCune Albright Syndrome)
5.	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)

Experts

1.	Bansal, Sagar: 1 article (05/2021)
2.	Kambli, Mrinal: 1 article (05/2021)
3.	Mishra, Shaswat: 1 article (05/2021)
4.	Parihar, Mangal: 1 article (05/2021)
5.	Pawar, Eknath: 1 article (05/2021)
6.	Yadav, Amit Kumar: 1 article (05/2021)
7.	Kopel, Jonathan: 1 article (12/2020)
8.	Quick, Donald P: 1 article (12/2020)
9.	Swarup, Sriman: 1 article (12/2020)
10.	Thirumala, Seshadri: 1 article (12/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Monostotic Fibrous Dysplasia:

1.	Therapeutic UsesIBA 11/01/2012 - "The aim of this study was to analyze the therapeutic effect of external auditory canal stenosis caused by monostotic fibrous dysplasia of the temporal bone by operation. "
2.	Growth Hormone (Somatotropin)IBA 09/01/2019 - "In such syndrome, phenotypes are heterogeneous and comprised polyostotic/monostotic fibrous dysplasia, café au lait macules, and hyperfunctioning endocrinopathies as the excess growth hormone. " 12/01/2003 - "The McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies including growth hormone (GH) excess. "
3.	Diphosphonates (Bisphosphonates)IBA 01/01/2016 - "We may conclude that conservative surgery might not be the best choice for treatment for monostotic fibrous dysplasia in the mandible and that other options must be considered, such as radical surgery or the use of bisphosphonates. " 09/01/2016 - "We report on the clinical and biochemical outcomes in a 20-year-old male suffering from active craniofacial monostotic fibrous dysplasia (MFD) of the left mandible treated with the RANK-L inhibitor, denosumab, following unsatisfactory responses to prior long-term bisphosphonates therapy. "
4.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 09/10/2020 - "Monostotic Fibrous Dysplasia Mimicking Metastasis in the Femoral Neck on Bone Scintigraphy and 18F-FDG PET/CT."
5.	Human Growth Hormone (Saizen)FDA LinkGeneric 09/01/2014 - "McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies including human growth hormone excess. "
6.	Gs GTP-Binding Protein alpha Subunits (G(s)alpha)IBA 07/01/2004 - "The present report describes a patient with monostotic fibrous dysplasia which diagnosis was confirmed by sequencing of the G(S)alpha gene, demonstrating a heterozygous missense mutation on codon 201 (201C --> T). "
7.	TitaniumIBA 05/01/2021 - "Titanium elastic nailing (TENS) with wedge osteotomy for the management of monostotic fibrous dysplasia (FD) of tibia is done in a 6-year-old male patient. "
8.	Heparin (Liquaemin)FDA LinkGeneric 12/01/2020 - "Spontaneous heparin induced thrombocytopenia (HIT) following curettage and bone graft of femur in a patient with monostotic fibrous dysplasia."
9.	Codon (Codons)IBA 07/01/2004 - "The present report describes a patient with monostotic fibrous dysplasia which diagnosis was confirmed by sequencing of the G(S)alpha gene, demonstrating a heterozygous missense mutation on codon 201 (201C --> T). "
10.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 04/01/2003 - "The long-term follow-up case of monostotic fibrous dysplasia of the maxilla in a 10-year-old girl is described with her endocrinologic data and therapeutic consequence of calcitonin administration in association with surgical interventions. "

Therapies and Procedures

1.	Intramedullary Fracture Fixation 06/01/2008 - "Prophylactic intramedullary nailing in monostotic fibrous dysplasia." 06/01/2008 - "Prophylactic intramedullary nailing appeared to be beneficial in monostotic fibrous dysplasia with scintigraphically proven activity and functional pain. " 06/01/2008 - "This study presents the results of prophylactic intramedullary nailing in 10 patients with monostotic fibrous dysplasia, pain increasing with movement, and scintigraphically established activity. "
2.	Mastoidectomy 11/01/1993 - "We present a case of monostotic fibrous dysplasia of the temporal bone coincident with a cholesteatoma of the EAC, operated on by mean of a modified radical mastoidectomy, with good results."
3.	Conservative Treatment 10/01/2006 - "We report the case of a middle-aged woman with longstanding monostotic fibrous dysplasia who responded well to conservative treatment. "
4.	Curettage 09/01/2012 - "Monostotic fibrous dysplasia of the mandible is an unusual manifestation of the disease that is usually benign, occurs in young individuals, and is managed by conservative curettage or debridement, such as surgical sculpting. " 05/01/2001 - "Monostotic fibrous dysplasia of the mandible is an unusual manifestation of the disease that is usually benign, occurs in young individuals, and is managed by conservative curettage or debridement. " 12/01/2020 - "Spontaneous heparin induced thrombocytopenia (HIT) following curettage and bone graft of femur in a patient with monostotic fibrous dysplasia."
5.	Osteotomy 05/01/2021 - "Wedge Osteotomy with Tens Nailing in Monostotic Fibrous Dysplasia of Tibia - A Case Report." 01/01/2004 - "We report a case of two-stage corrective osteotomy for severe varus-retroversion deformity of the femoral neck due to monostotic fibrous dysplasia. " 05/01/2021 - "Titanium elastic nailing (TENS) with wedge osteotomy for the management of monostotic fibrous dysplasia (FD) of tibia is done in a 6-year-old male patient. "