Fibrosarcoma

A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)

Also Known As:

Networked: 4378 relevant articles (108 outcomes, 420 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Adenocarcinoma
4.	Neoplasm Metastasis (Metastasis)
5.	Melanoma (Melanoma, Malignant)

Experts

1.	Ikejima, Takashi: 20 articles (02/2015 - 03/2004)
2.	Onodera, Satoshi: 19 articles (02/2015 - 03/2004)
3.	Hoffman, Robert M: 14 articles (05/2015 - 01/2003)
4.	Tsuchiya, Hiroyuki: 13 articles (06/2013 - 01/2003)
5.	Tashiro, Shin-Ichi: 12 articles (02/2015 - 03/2004)
6.	Yamamoto, Norio: 11 articles (01/2012 - 01/2003)
7.	Kim, Moon-Moo: 10 articles (05/2015 - 11/2006)
8.	Smyth, Mark J: 10 articles (10/2013 - 07/2002)
9.	Tomita, Katsuro: 10 articles (01/2012 - 01/2003)
10.	Ando, Koichi: 9 articles (11/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fibrosarcoma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 04/01/2015 - "Commonly used chemotherapeutic agents like doxorubicin have proven to be effective in <30% of all cases of disseminated fibrosarcoma. " 02/01/2015 - "Commonly used chemotherapeutic agents such as doxorubicin have been proven effective in fewer than 30% of all cases disseminated of fibrosarcoma. " 01/01/2015 - "The results indicate that Au-GSH-Dox may be a potent new therapeutic agent to increase the efficacy of the drug by overcoming the resistance to doxorubicin in feline fibrosarcoma cell lines. " 07/20/1995 - "In the present study, the wild type p53 protein in human fibrosarcoma HT1080 cells were targeted with HPV-18 E6 and the viability of these cells in response to treatment with adriamycin, u.v.-irradiation and gamma-irradiation was examined. " 06/01/1992 - "The current study examines the radiation response of a human fibrosarcoma (HT1080) and a doxorubicin-resistant subline (HT1080/DR4). "
2.	MethylcholanthreneIBA 01/01/2002 - "The aim of the study was the evaluation of angiogenesis processes in fibrosarcoma induced by 3-methylcholanthrene (3-Mc) in reference to the number of mast cells (MCs). " 05/01/2001 - "The current experimental work deals with the chemopreventive studies of a hydroalcoholic extract of Withania somnifera roots, against 20-methylcholanthrene induced fibrosarcoma tumours in Swiss albino mice. " 04/01/1997 - "CBA/HZgr mice and methylcholanthrene-induced fibrosarcoma were used in these studies. " 01/01/1990 - "The objective of our study was to determine whether and how frequently MHC class I gene alterations occur in fibrosarcomas induced in BALB/c mice by the carcinogen 3-methylcholanthrene (3-MCA). " 10/15/1989 - "The present study examines clonal variations in NK sensitivity in a methylcholanthrene-induced fibrosarcoma. "
3.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 03/01/2008 - "In the current study we evaluated the signaling pathways involved with PH-PDT-mediated COX-2 expression in a mouse fibrosarcoma cell line. " 11/01/1999 - "Our study showed that BFS1 fibrosarcoma is highly sensitive to PDT after application of new sensitizers. " 10/01/1999 - "The PDT effects of these sensitizers have been studied in a mouse model bearing the RIF-1 murine fibrosarcoma line studying tumour regrowth delay, phosphate metabolism by magnetic resonance spectroscopy (MRS) and blood flow, using D2O uptake and MRS. " 04/01/1997 - "Rif-1 mouse fibrosarcoma cells and a PDT resistant derivative, Rif-8A, as well as Chinese hamster ovary (CHO) cells and CHO-MDR multi-drug resistant mutant cells were studied. " 01/01/1995 - "ALA-PDT was less effective than PHP-based therapy at inhibiting the growth of a subcutaneous rat fibrosarcoma at light doses over 300 J. "
4.	Interleukin-2 (IL2)IBA 10/15/1999 - "In this study, T cells from lymph nodes draining the murine fibrosarcoma MCA 205 cells were activated ex vivo with anti-CD3 monoclonal antibody and interleukin-2. " 04/01/1984 - "A temporal study assessed the relationship between fibrosarcoma growth and immunologic encumbrance due to the inability of BALB/c mouse splenocytes to elaborate the lymphokine Interleukin 2 (IL-2). " 12/01/2007 - "Homing of radiolabelled recombinant interleukin-2 activated natural killer cells and their efficacy in adoptive immunotherapy against murine fibrosarcoma." 12/01/2003 - "Given these distribution characteristics and their well-documented safety profile, ALVAC- or NYVAC-based recombinants expressing feline or human IL2, respectively, were administered to domestic cats, in order to prevent the recurrence of spontaneous fibrosarcomas. " 04/01/2001 - "TDLNs were recovered from mice bearing progressive MCA 205 fibrosarcomas, and the T lymphocytes were segregated into CD62L(low) and CD62L(high) subsets and activated ex vivo with anti-CD3 mAb and IL-2. "
5.	Cisplatin (Platino)FDA LinkGeneric 09/01/2005 - "The aim of this study was to determine the effects of low-voltage electrochemotherapy with intraperitoneal cisplatin on hamster oral fibrosarcoma. " 01/15/1995 - "As a suitable model to study the growth behavior and therapeutic response of drug-resistant and -sensitive cells in three-dimensional coculture we have established multicellular spheroids generated from both cisplatin-sensitive and -resistant cells of a murine fibrosarcoma cell line. " 10/01/2006 - "A0, a Cu(II) thioxotriazole complex, produces severe cytotoxic effects on HT1080 human fibrosarcoma cells with a potency comparable to that exhibited by cisplatin. " 09/01/2005 - "These results clearly indicate that the anti-tumour effect of cisplatin on hamster oral fibrosarcoma was considerably potentiated or enhanced by the administration of local electrical pulses at low voltages." 09/01/2005 - "Enhanced anti-tumour effect of cisplatin with low-voltage electrochemotherapy in hamster oral fibrosarcoma."
6.	CollagenIBA 01/01/1994 - "This native collagen heteropolymer represented approximately 18% of the total collagen from rat fibrosarcoma and as such provides a unique natural source of this collagen complex for further analytical studies." 07/01/2015 - "Fibrosarcoma has been defined as a malignant mesenchymal tumour, the cells of which recapitulate the appearance of the normal fibroblast, with variable collagen production. " 03/18/2014 - "Here, we quantified the migration patterns of individual fibrosarcoma cells on 2D substrates and in 3D collagen matrices and found that 3D migration does not follow a random walk. " 10/01/2009 - "Fibrosarcoma cells migrated through endothelial cells into collagen gel. " 03/01/2009 - "HT1080 cells migrated through endothelial cells into collagen gel, the electrical resistance of a HUVEC monolayer was reduced and endothelial MLC phosphorylation was enhanced in extravascular migration of fibrosarcoma cells. "
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2015 - "L929 fibroblastoma cells (L929-A) and L929 fibrosarcoma cells (L929-N) are different cell lines that are commonly used to study the cytotoxicity of tumor necrosis factor alpha (TNFα). " 01/01/2001 - "The aim of the present study was the ultrastructural characteristics of mast cell (MC) involved in host antitumor responses induced by local (i.t.) administration of recombinant human tumor necrosis factor alpha (rhTNF-alpha) in the primary focus of methA fibrosarcoma. " 05/01/1990 - "In this study, we detected the in vivo release of bovine TNF-alpha by using WEHI-164 murine fibrosarcoma cells as targets in an 18-h cytotoxicity assay. " 07/31/2015 - "Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929." 01/01/2015 - "Assay of macrophages culture supernatants were carried out on WEHI-164 fibrosarcoma cell line as tumor necrosis factor-α bioassay were done. "
8.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 04/01/2003 - "In the present study, the effects of cyclophosphamide (Cp, a widely used alkylating agent) were monitored in a murine radiation induced fibrosarcoma (RIF-1) using in vivo (1)H NMR spectroscopy and imaging to evaluate the potential of these techniques towards early detection of treatment response. " 05/01/1992 - "In this study, the pretreatment of endothelial cell monolayers and mice with cyclophosphamide (CPA) was respectively shown to promote the adhesion of HT1080 human fibrosarcoma cells to endothelial cell monolayers in vitro and lung colonization in vivo. " 11/01/2001 - "murine radiation-induced fibrosarcoma (RIF-1) model before and after cyclophosphamide treatment. " 04/01/1999 - "Cyclophosphamide (range, 10 to 100 mg/kg) was administered intraperitoneally into mice 4 days following the injection of 3.5 x 10(5) viable fibrosarcoma (FSa) cells. " 08/01/1996 - "With a spontaneous mutation frequency in C3H mice of 1.5 x 10(-6), mutation frequencies increased from 6.2 x 10(-6) to 2.0 x 10(-5) as the cyclophosphamide dose increased from 50 to 200 mg/kg. C3H male mice had 3.5 x 10(5) viable fibrosarcoma cells injected into their tail veins. "
9.	Phosphotransferases (Kinase)IBA 10/01/2015 - "Overall, these observations indicate that the hypomethylating agent 5'-aza modulates COX-2 expression via the PI3-kinase/Akt and ERK-1/2 pathways in human HT1080 fibrosarcoma cells." 01/01/2014 - "As in humans, knockdown of receptor-interacting kinase-3 (RIPK3) or mixed lineage kinase domain like (MLKL) blocks TNF-induced necroptosis in L929 fibrosarcoma cells. " 02/01/2013 - "The cutaneous effects of rapidly accelerated fibrosarcoma kinase B (BRAF) inhibitors are not well understood. " 03/01/2007 - "Here we report that in HT1080 fibrosarcoma cells, Src kinase activity is required not only for the assembly of FN matrix but also for the maintenance of FN matrix fibrils at the cell surface. " 12/24/2004 - "Interestingly, overexpression of the kinase domain deleted and kinase-inactive mutants of hMINK beta in human fibrosarcoma HT1080 cells enhanced cell spreading, actin stress fiber formation, and adhesion to extracellular matrix, as well as decreased cell motility and cell invasion. "
10.	Transforming Growth Factor beta (TGF-beta)IBA 06/01/1988 - "The present study was undertaken to characterize the 8387 fibrosarcoma cell-derived factor(s) and to investigate its relationships to TGF beta by analysis of modulation of PA activity and cell growth. " 02/01/2013 - "Transforming growth factor beta 2 (TGFβ2) has been established to regulate processes correlated to fibrosarcoma tumorigenesis. " 01/23/2008 - "Here, we found that TGF-beta induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. " 01/23/2008 - "Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma." 03/03/2004 - "When smad3-Delta3 is overexpressed in a fibrosarcoma cell line, the Smad3-Delta3 is translocated to the nucleus upon TGF-beta stimulation and binds the Smad responsive element. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2003 - "The authors describe a patient with a large retroperitoneal infantile fibrosarcoma that responded well to preoperative chemotherapy, which subsequently facilitated the complete surgical resection of the mass. " 10/01/1985 - "Chemotherapy as a single modality appears to be effective in controlling unresectable infantile fibrosarcoma." 01/01/2005 - "This study demonstrates that chemotherapy regulates the expression of apoptosis-related factors in fibrosarcoma cells. " 11/01/2015 - "Here we have shown that FAP overexpression increased the growth of HT1080 fibrosarcoma cells in vitro and in vivo, and found that the expression of FAP affects response to chemotherapy. " 11/01/2015 - "Integral membrane protease fibroblast activation protein sensitizes fibrosarcoma to chemotherapy and alters cell death mechanisms."
2.	Heterologous Transplantation (Xenotransplantation) 05/27/2014 - "More importantly, the therapeutic efficacy of α-NTP-LNs was specific to NPC xenograft formed with 5-8F cells but not to fibrosarcoma xenograft formed with HT1080 cells in vivo. " 07/28/2014 - "The affinity towards ETAR was confirmed in vitro by cell binding assays on human fibrosarcoma cells (HT-1080) and in vivo by murine xenograft imaging studies. " 05/01/2009 - "In this study, the human fibrosarcoma xenograft HT1080 was transplanted into the leg muscle of athymic mice. " 09/01/2014 - "TIMP-1-GPI treatment was validated using HT1080 fibrosarcoma murine xenografts. " 09/01/2013 - "Photochemical internalization (PCI) is a modality for cytosolic drug delivery, but recent data on contrast-enhanced MRI have indicated that the method also reduces blood perfusion in HT1080 fibrosarcoma xenografts. "
3.	Photochemotherapy (Photodynamic Therapy) 07/01/1996 - "The red shift of the absorption spectrum is consistent with the therapeutic efficacy of the photodynamic therapy which was measured at 672, 685 and 695 nm, and proved to be maximum at 685 nm for both the L1210 leukaemia and the MS-2 fibrosarcoma. " 05/01/1999 - "Photodynamic therapy with 2-iodo-5-ethylamino-9-diethylaminobenzo[a]-phenothiazinium chloride (2I-EtNBS) eradicated EMT-6 mammary fibrosarcomas in 75-100% of treated mice. " 01/01/2001 - "Two distinct photodynamic therapy-resistant variants of the murine radiation-induced fibrosarcoma (RIF) cell line have been isolated. " 01/01/1995 - "The response of a rodent fibrosarcoma to combined treatment with photodynamic therapy and radiotherapy." 07/01/1990 - "The response of a rodent fibrosarcoma to superficial/interstitial photochemotherapy, chemotherapy or radiotherapy."
4.	Immunotherapy 03/01/2011 - "We used a murine immunogenic fibrosarcoma that evolves to a tolerogenic state, to study the cellular and molecular mechanisms underlying tolerance induction at the level of TDLN and to design an appropriate immunotherapy. " 07/01/2010 - "As the JBS fibrosarcoma is weakly immunogenic and accumulates Treg in its microenvironment with progressive growth, we used this tumour model to test our combined immunotherapies. " 01/01/2009 - "Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination." 01/01/1994 - "The results may shed light on a novel parameter affecting tumour-host interactions, namely cytokine expression by the tumorous cells, and may provide the basis for new immunotherapy protocols for fibrosarcoma management." 04/01/1984 - "Successful immunotherapy in a murine metastasizing fibrosarcoma model."
5.	Injections 08/01/1993 - "injections of a larger dose (50 mg/kg/d x 3) were equally effective against the solid form of Meth A fibrosarcoma. " 03/10/1959 - "Studies on the inhibition of growth of an implanted fibrosarcoma in rats; the effect of fat in the diet with and without injections of guinea pig serum." 01/01/2012 - "Fibrosarcoma is a deadly disease in cats and is significantly more often located at classical vaccine injections sites. " 07/01/2006 - "Fibrosarcomas at the site of injections have been reported in dogs and ferrets. " 05/01/1995 - "We used a human fibrosarcoma cell line (HT-1 080) with low metastatic potential, and a subpopulation of HT-1 080 (HT-1 080-P4) with high metastatic potential which was selected by repeating injections into the tail veins of athymic mice. "