Fibronectins (Fibronectin)

Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.

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Networked: 6856 relevant articles (148 outcomes, 753 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Neri, Dario: 57 articles (11/2015 - 03/2002)
2.	Roman, Jesse: 26 articles (06/2013 - 02/2002)
3.	Ritzenthaler, Jeffrey D: 16 articles (06/2013 - 02/2002)
4.	Zardi, Luciano: 16 articles (02/2013 - 03/2002)
5.	Chakrabarti, Subrata: 13 articles (08/2015 - 06/2003)
6.	Chatterjee, Amitava: 12 articles (10/2013 - 02/2005)
7.	Goldenberg, R L: 12 articles (09/2001 - 01/2000)
8.	Borsi, Laura: 11 articles (08/2013 - 03/2002)
9.	Trachsel, Eveline: 11 articles (04/2012 - 04/2006)
10.	Vis, Jolande Y: 10 articles (09/2015 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2009 - "Epitope mapping of 6A3 may help to understand the interaction between fibronectin and rDPP IV. In the present study, we showed that 6A3 species-specifically recognized rDPP IV but inhibited fibronectin/rDPP IV-mediated cell adhesions of various cancer types and species, which was independent of rDPP IV enzymatic activity. " 07/01/1995 - "alpha v beta 1 upmodulation was concomitant with improved tumor cells attachment to the fibronectin matrix. " 07/07/2015 - "In this study, we use both biochemical and physical tools coupled with engineered models, patient samples, and a murine model to investigate the role of the mechanical properties of the tumor microenvironment in regulating the production of the extra domain-B (EDB) splice variant of fibronectin (FN), a hallmark of tumor angiogenesis. " 01/22/2015 - "To our knowledge, this is the first study illustrating Pak1-NF-κB-p65-mediated fibronectin regulation as a potent tumor-promoting mechanism in KRAS intact model. " 01/01/2015 - "Our previous studies utilizing a series of immortalized GBM cell lines established a functional causation between activation of fibronectin matrix assembly (FNMA), increased tumor cohesion, and decreased dispersal. "
2.	Infection 08/01/2007 - "Both A-MLV entry and fibronectin turnover depend on caveolar endocytosis, and we found that inhibiting viral binding to the extracellular NIH 3T3 fibronectin-matrix dramatically reduced A-MLV infection, indeed, showing an active role of fibronectin in infection. " 08/01/1996 - "Here we report that (1) transduction of reconstituting murine HSC assayed 12 months after infection with retrovirus supernatant on FN 30/35 is as effective as cocultivation directly on producer cells; (2) recombinant retrovirus particles directly adhere to FN 30/35 in a quantitative and dose-dependent fashion; and (3) increased transduction efficiency on FN 30/ 35 does not appear to be associated with increased cell proliferation or activation of protein phosphorylation typically induced by integrin-fibronectin interactions. " 04/30/2004 - "In addition, fibronectin was shown to improve the rate of infection with HIV-1." 12/01/2003 - "The fibronectin-binding repeats of the SfbI protein of Streptococcus pyogenes constitute the minimal domain able to confer protection against lethal infection. " 01/01/2001 - "Spinoculation and static fibronectin (FN)-assisted infections improved to a similar extent the transduction efficiency of PHA/IL-2 stimulated T cells, when compared with samples subjected to standard static infections. "
3.	Wounds and Injuries (Trauma) 06/01/2011 - "In this study, plasma fibronectin levels were measured before and after VAC in patients with wounds. " 01/01/2003 - "Furthermore, immunohistochemical studies revealed that at the wound site a meshwork of fibronectin developed that can support the migration of the DiI-labelled cells. " 11/01/1996 - "These studies identified two factors that may contribute to delayed healing of chronic wound: fibronectin degradation and overexpression of matrix metalioproteinases." 09/01/1992 - "More recently, investigators have begun to study fibronectin's role in chronic wounds. " 02/01/1988 - "Whether the addition of exogenous fibronectin to wounds can augment healing is a question for future studies."
4.	Premature Obstetric Labor (Premature Labor) 04/01/1997 - "Cervicovaginal fetal fibronectin detected by a rapid bedside swab-test in women with symptoms of preterm labor compares favourably with quantitative assays and could prove useful in the management of preterm labor. " 02/01/2005 - "In a population of patients with signs and symptoms of preterm labor, the presence of cervical fetal fibronectin is effective in predicting risk of delivery within 7, 14, or 21 days. " 02/01/2003 - "Studies of cervical sonography, fetal fibronectin, and uterine contraction monitoring during pregnancy have improved our understanding of how preterm labor occurs, but their use in practice remains uncertain. " 10/01/2005 - "A randomized multicenter study to determine the efficacy of activity restriction for preterm labor management in patients testing negative for fetal fibronectin." 01/01/1996 - "The results for the prediction of preterm labor differ according to whether we consider a single positive result (fetal fibronectin > 50 ng/ml) as predictive of preterm labor or whether we only consider at least two consecutive positive results as predictive of perterm labor. "
5.	Premature Birth (Birth, Premature) 08/01/2001 - "Of these, fetal fibronectin and endovaginal ultrasound examination of the cervix have proven effective in predicting which symptomatic women are actually at low risk of preterm birth. " 03/01/2005 - "To assess efficacy of cervico-vaginal fetal fibronectin as a predictor of spontaneous preterm birth in a high risk antenatal population, and to evaluate the psychological impact of fetal fibronectin testing. " 07/01/1997 - "As an example, the risk of spontaneous preterm birth at < 30 weeks for women with two negative fetal fibronectin test results at 24 and 26 weeks was 0.3% versus 16% for women with two positive results. " 09/01/2015 - "The aim of the study was to investigate whether cervical sonoelastography improves prediction of spontaneous preterm birth compared with cervical length measurement and a fetal fibronectin (fFN) test. " 01/01/2015 - "The purpose of this study was to determine the effect of sexual intercourse on the accuracy of quantitative fetal fibronectin (qfFN) in the prediction of spontaneous preterm birth (sPTB) in asymptomatic high-risk women. "

Related Drugs and Biologics

1.	Collagen
2.	Laminin (Merosin)
3.	Messenger RNA (mRNA)
4.	Transforming Growth Factor beta (TGF-beta)
5.	Collagen Type I (Type I Collagen)
6.	Peptides
7.	Transforming Growth Factors (Transforming Growth Factor)
8.	Transforming Growth Factor beta1 (TGF beta 1)
9.	Cytokines
10.	Fibrinogen (Factor I)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Nutritional Support (Artificial Feeding)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Drug Therapy (Chemotherapy)
5.	Homologous Transplantation (Allograft)