Fibrinolytic Agents (Antithrombotic Agents)

07/05/2005 - "Recent studies have indicated that a selective inhibitor of TAFIa could enhance the efficacy of existing thrombolytic agents for the treatment of acute myocardial infarction, one of the most prevalent forms of heart attacks. "
01/01/2004 - "This review examines the most significant trends in the pharmacologic therapy of ST-segment elevation myocardial infarction since the publication of these early studies: the development of fibrinolytic drugs with improved clot selectivity and improved pharmacokinetic profiles that simplify administration, making ED or even prehospital thrombolysis more practical. "
01/01/1984 - "The development of newer specific thrombolytic agents with low toxicity, without antigenicity, and available for rapid parenteral administration holds much promise for the treatment of acute myocardial infarction in the future."
10/01/2004 - "Patients in clinical trials of fibrinolytic agents have been shown to be younger, less often female, and to have lower risk characteristics and a better outcome compared with unselected patients with ST-elevation myocardial infarction. "
02/01/2013 - "Expedited treatment may influence the efficacy of nonfibrin specific thrombolytic agents in restoring early patency of the infarct-related artery (IRA), which is a major determinant of survival after ST-elevation myocardial infarction (STEMI). "

11/01/2011 - "Animal models of venous and arterial thrombosis are extremely useful to study the efficacy of antithrombotic agents. "
04/01/2013 - "However, intraprocedural thrombosis developed in one patient, which was resolved completely by intraarterial thrombolytic agents. "
01/01/2014 - "Because of its high sensitivity and reproducibility, the FeCl3 -induced arterial thrombosis mouse model is widely used to study molecular mechanisms as well as the efficacy of antithrombotic agents. "
12/01/2010 - "Thrombolytic agents are an attractive form of early therapy because they have the ability to eliminate obstructive thrombus in the deep veins, and should therefore help provide protection against PTS. Perceived benefits of early and rapid recanalization in preserving valve function have been the basis for lytic therapy to treat acute DVT. "
01/01/2002 - "Thrombolytic agents have been successfully employed in each of these areas, achieving dissolution of the occluding thrombus, reconstitution of blood flow, and improvement in the status of the tissue bed supplied or drained by the involved vascular segment. "

08/01/2008 - "Examples such as enhancement of thrombolytic agents by ultrasound have proven to be beneficial for acute stroke patients and peripheral arterial occlusions. "
01/01/2004 - "Recent clinical trials have suggested that other antithrombotic agents may be beneficial in acute ischemic stroke. "
01/01/2004 - "Patient compliance with the recommended treatment is of major importance, given the somewhat limited efficacy of antithrombotic agents in stroke prevention. "
10/01/2002 - "Available antiplatelet regimens offer only partial protection against stroke and more efficacious antithrombotic agents would be useful. "
08/01/1999 - "Ultrafast MR imaging permitted immediate triage of 35 patients with symptoms of hyperacute stroke and thus helped avoid the risks from angiography and thrombolytic agents in some or spurred the judicious use of more aggressive intervention in others."

01/01/2015 - "Bleeding and embolic risks associated with thrombolytic agents, the limited efficacy of thrombolysis in certain subgroups, and a lack of experience in the setting of pregnancy raise important concerns. "
04/01/2001 - "Although current thrombolytic agents have proven their clinical benefit, the failure to rapidly reperfuse some patients and the persistent bleeding risk represent areas for improvement in therapy. "
02/01/1987 - "Appropriate dose regimens for thrombolytic agents in specific clinical situations is critical to maximize therapeutic efficacy while minimizing the risk of significant bleeding."
01/01/2011 - "Anti-fibrinolytic drugs are widely used, particularly in cardiac surgery, and previous reviews have found them to be effective in reducing blood loss, the need for transfusion, and the need for re-operation due to continued or recurrent bleeding. "
01/01/2011 - "Anti-fibrinolytic drugs are widely used, particularly in cardiac surgery, and previous reviews have found them to be effective in reducing blood loss, the need for transfusion, and the need for re-operation due to continued or recurrent bleeding. "

10/01/1995 - "Thrombolytic agents have been used successfully to treat patients with massive pulmonary embolism and cardiorespiratory insufficiency, but experience with these drugs in pregnancy is limited. "
03/01/1993 - "Thrombolytic agents are widely used as first line treatment in severe acute pulmonary embolisms. "
11/01/2005 - "Efficacy of thrombolytic agents in the treatment of pulmonary embolism."
03/01/2015 - "These variables remain significantly associated with mortality after adjusting by Acute Physiology and Chronic Health Evaluation IV score, Pulmonary Embolism Severity Index score, or the use of thrombolytic agents. "
01/01/2014 - "The use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism (PTE) remains controversial. "