Fibrinogen (Factor I)

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

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Networked: 10189 relevant articles (263 outcomes, 1183 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rumley, Ann: 33 articles (09/2015 - 07/2002)
2.	Tracy, Russell P: 28 articles (10/2015 - 02/2002)
3.	Degen, Jay L: 25 articles (10/2015 - 12/2002)
4.	Neerman-Arbez, Marguerite: 25 articles (01/2015 - 03/2003)
5.	Lowe, Gordon D O: 25 articles (08/2013 - 07/2002)
6.	Koenig, Wolfgang: 23 articles (08/2015 - 02/2003)
7.	Folsom, Aaron R: 21 articles (12/2015 - 12/2002)
8.	Shapira, Itzhak: 20 articles (04/2015 - 01/2002)
9.	Berliner, Shlomo: 20 articles (04/2015 - 01/2002)
10.	de Maat, Moniek P M: 18 articles (04/2015 - 08/2002)

Related Diseases

1.	Hemorrhage 09/01/2013 - "Replacement therapy is effective in treating bleeding episodes, but because the pharmacokinetics of fibrinogen after replacement therapy is highly variable among patients, it is important to adjust the treatment individually. " 06/01/2009 - "Replacement therapy is effective in treating bleeding episodes, but it is important to tailor individual treatments because the pharmacokinetics of fibrinogen after replacement therapy is highly variable among patients. " 06/01/2015 - "Fibrinogen concentrate limits postoperative bleeding after complex heart surgery, leading to a significant reduction in allogeneic blood products transfusions. " 05/01/2005 - "On multiple logistic regression analysis, cortical location of bleeding (odds ratio 3.79 (95% confidence interval 1.2 to 12.01); p = 0.023), high CSS score (OR 2.3 (1.6 to 3.1); p<0.0001), and low fibrinogen concentrations (OR 0.92 (0.87 to 0.97); p = 0.001) were independent predictors of good outcome. " 03/01/2013 - "FIBTEM-guided intraoperative hemostatic therapy with fibrinogen concentrate is more effective than placebo in controlling coagulopathic bleeding during major aortic replacement surgery. "
2.	Neoplasms (Cancer) 08/01/2015 - "Receiver operating characteristic analyses showed that including plasma fibrinogen level alongside traditional factors (tumor stage and CA 19-9) significantly improved prognostic prediction capability (traditional model area under the curve of 0.62 versus combined model area under the curve of 0.708; P = 0.016). " 06/01/2009 - "The purpose of this study was to evaluate the association between fibrinogen plasma levels on disease-free patients and overall survival in patients with cervical cancer. " 03/01/2012 - "In a multivariate survival analysis, tumor stage (p=0.006/p=0.02) and lymph node involvement (p<0.001/p<0.001), but neither histological grade (p=0.2/p=0.9) nor plasma fibrinogen levels (p=0.6/p=0.6) were associated with disease-free and overall survival, respectively. " 04/30/1983 - "In these patients, the behavior of fibrinogen was normal, suggesting that the parameters studied are related to the presence of the tumor, and can be useful in monitoring the state of remission." 08/01/1977 - "A combination of the large tumour concentration of I-fibrinogen, an increased catabolic rate induced by chemical modification, and the exceptional nuclear properties of 123I for scintigraphic imaging, could lead to a very useful radiodiagnostic procedure for cancer."
3.	Thrombosis (Thrombus) 01/01/2010 - "There was a significant reduction in thrombus formation in the 4 h group compared with control (median weight, 0.000 versus 0.565mg/mm, P < .01; median % 125I-fibrinogen accretion, 0.0 versus 42.0%, P < .01). " 10/08/1983 - "Its field of application is limited in that the pelvic veins (iliac veins excepted) and the deep femoral vein are imperfectly explored or unexplored, but it is superior to other methods - such as labelled fibrinogen, Döppler ultrasonography or rheography - which are less sensitive, less specific and unable to localize precisely the site and extension of the thrombosis. " 09/01/1995 - "The data provide morphological evidence for the selective, GPIIb-IIIa mediated, actin-dependent clearance of bound fibrinogen from the activated platelet surface, suggesting a mechanism for preventing and limiting thrombus development." 11/01/2005 - "Since fibrinogen plays a key role in the regulation of both haemostasis and thrombosis, high-resolution AFM imaging on SAMs is expected to be an effective approach to study the haemocompatibility of materials with different surface chemistry." 07/01/2003 - "ECC blood flow was at least 75 ml/min. Platelet and fibrinogen measurements were made hourly, and circuit dosimetry was performed at the end of the study or on circuit thrombosis. "
4.	Wounds and Injuries (Trauma) 08/01/2012 - "The routinely used clotting parameters markedly improved between admission to the trauma bay and ICU admission: Quick 61% versus 97% (p < 0.001), partial prothromboplastin time (PTT) 50 s versus 42 s (not significant), fibrinogen 1.7 g/l versus 2.15 g/l (not significant). " 06/01/2014 - "Randomized trials are warranted to determine whether FC improves outcomes in prehospital management of trauma patients or whether FC is superior to another source of fibrinogen in early hospital management of trauma patients." 02/01/2013 - "Administration of fibrinogen concentrate in exsanguinating trauma patients is associated with improved survival at 6 hours but not at discharge." 01/01/2010 - "Restoring fibrinogen with 70 or 200 mg kg-1 after severe dilutional coagulopathy safely improved coagulation and attenuated blood loss after experimental blunt liver trauma. " 12/01/1982 - "Following closure of this capsule wound with fibrinogen glue the extensive subcapsular posterior rosette opacities regressed markedly and visual acuity improved from 0.1 to 0.7. "
5.	Stroke (Strokes) 11/01/2013 - "Long-term oral fibrinogen-depleting therapy may be beneficial for secondary ischemic stroke prevention." 01/01/2012 - "Fibrinogen concentrations were determined by the Clauss method on admission, immediately after TLT, and daily during the first 7 days of observation; the efficacy of thrombolysis was evaluated using the NIH stroke scale every day, the Rankin scale, and the Barthel Index on days 14 and 21. " 07/01/2015 - "Several investigations have been performed to examine the influence of the β-fibrinogen (FGβ) gene polymorphisms on the risk of ischemic stroke, but the results of these studies are controversial. " 03/01/2015 - "Fibrinogen alpha and beta gene polymorphisms in pediatric stroke--case-control and family based study." 01/01/2015 - "To clarify the relationship between the β-fibrinogen (FGB) genetic polymorphism (-148C>T) and ischemic stroke, we identified studies by searching PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CKNI) databases. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Fibrin
3.	Thrombin
4.	Heparin (Liquaemin)
5.	fibrin fragment D (D-dimer)
6.	Plasminogen Activators (Plasminogen Activator)
7.	LDL Cholesterol
8.	Antithrombin III
9.	Cholesterol
10.	Insulin (Novolin)

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3.	Plasmapheresis
4.	Spinal Fusion (Spondylosyndesis)
5.	Lasers (Laser)